Information for:

Pharmacology and Toxicology

Head of Pharmacology and Toxicology Department
Assoc. Prof. Reham Abdel-Kader

Email: reham.abdelkader@guc.edu.eg
Office:B3.111
Ext:3419

Biography	Reham Abdel-Kader is currently an Associate professor of Pharmacology and Toxicology and the Head of the Pharmacology, Toxicology and Clinical pharmacy department in the faculty of pharmacy and biotechnology at the GUC . She first joined the GUC in 2003 as a teaching assistant and then travelled to Frankfurt/Germany in 2004 to pursue her Postgraduate studies. She earned her doctoral degree in 2009 at the institute of Pharmacology in Johann Wolfgang Goethe- University, in Frankfurt am Main. She completed her PhD on Alzheimer’s disease and its treatment and since then she developed a passion for research in the field of neuropharmacology. Throughout her academic path, she successfully supervised more than 20 MSc. and PhD students, participated in many international conferences worldwide, and she earned several research and travel grants. Currently, Reham Abdel- Kader is an international reviewer for research grants and peer-reviewed international journals such as journal of molecular neurobiology and neuroscience research journal. Moreover, her research group are collaborating with many national and international universities and industries such as Ulm University, Cairo university medical school, Ain shams university, and International Trade and Marketing Company.
Research Interests
1. Pathogenesis and novel treatment modalities for Neurodegenerative diseases. 2. Genetic implications in neurodevelopmental disorders; a pathway to personalized medicine. 3. Role of mitochondrial function and Biogenesis in Neurodegenerative disorders. 4. Neuropharmacology

Publications

2019

Journal 2019

Neuromodulatory activity of dietary phenolics derived from Corchorus olitorius
L. Reham Wagdy, Reham Abdelkader, Ahmed H. El-Khatib, Michael W.Linscheid,
Nabila Hamdi, Heba Handoussa Journal of Food Science (2019 )May 84(5)

2018

Journal 2018	The effect of Pyrroloquinoline quinone and Resveratrol on the Survival and Regeneration of Cerebellar Granular Neurons. Shanan N, GhasemiGharagoz A, Abdel-Kader R, Breitinger HG. Neurosci Lett. (2018).IF:2.159
Journal 2018	Enhancement of cognitive functions by rice bran extract in a neuroinflammatory mouse model via regulation of PPARγ A.O. Mostafa, R.M. Abdel-Kader, O.A. Heikal. Journal of Functional Foods 48 (2018) 314–321 IF: 3.470

2016

Journal 2016	Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aß in a Neuroinflammatory Alzheimer's Disease Mouse Model Zakaria A, Hamdi N, Abdel-Kader RM. : Mol Neurobiol. ,2016. (2018).IF:2.159
Journal 2016	Targeting of Cell Mockups using Sperm-Shaped Microrobots In Vitro Islam S.M. Khalil*, Ahmet Fatih Tabak, Abdelrahman Hosney, Anke Klingner, Marwan Shalaby, Reham M. Abdel-Kader, Mohamed Serry, Metin Sitti : 6th IEEE International Conference on Biomedical Robotics and Biomechatronics (BioRob) , 2016.
Conference 2016	Targeting of cancer cells using controlled nanoparticles and robotics sperms S. M. Khalil, R. M. Abdel-Kader, I. E. O. Gomaa, N. Serag, A. Klingner, and Mohamed Elwi, : Proceedings of the International Conference of Photodynamics an Nanomedicine for Health Sciences (ICPN) , 2016.
Conference 2016	Enhancement of cognitive functions by PQQ in neuroinflammatory Alzheimer’s disease mouse model via potential involvement of mitochondrial biogenesis Engy Fadel, Reham M. Abdel-Kader : 6. Alzheimer’s Diseases International, 2016.
Journal 2016	Targeted Penetration of MCF-7 Cells using Iron-Oxide Nano-Particles In Vitro. Mahmoud Elfar, Mariam Ayoub, Aya abdelbaky, Hazem Abass Mohamed, Reham M. Abdel-Kader, Islam S.M.Khalil : 6th IEEE International Conference on Biomedical Robotics and Biomechatronics (BioRob) , 2016.
Journal 2016	Inhibitory Activity of Benzo[h]quinoline and Benzo[h]chromene in Human Glioblastoma Cells Mogedda E Haiba, Ebtehal S Al-Abdullah, Hazem A Ghabbour, Sayed M Riyadh and Reham M Abdel-Kader :Trop J Pharm Res. , 2016.
Book 2016	Magnetic-Based Contact and Non-Contact Manipulation of Cell Mockups and MCF-7 Human Breast Cancer Cells (smart drug delivery system).Islam S. M. Khalil, Iman E. O. Gomaa, Reham M. Abdel-Kader and Sarthak Misra (2016)

2014

Journal 2014

Design and implementation of implanted antenna inside a human body. Abbassi P.K, Allam A.M.M.A. , Abdelkader R.M :Antenna Measurements & Applications (CAMA), 2014.

2013

Journal 2013

Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8.Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Müller WE, Rimbach G, Frank J. :

2012

Journal 2012	Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.Eckert GP, RennerK, Eckert SH, Eckmann J, Hagl S, Abdel-Kader RM, Kurz C, Leuner K, Muller WE : Mol Neurobiol. , 2012
Conference 2012	Methylene blue decreases brain mitochondrial ABAD and amyloid beta levels protecting mitochondrial functions in LPS-mouse model. Reham M Abdel-Kader, Aya Zakaria, Nabila Hamdi :Molecular Neurodegeneration., 2012.

2010

Conference 2010	Gold Nanoparticles Uptake, Localization and Behaviour In The Induction of Cell Death In Hepatocllular Carcinoma Cell Lines Abdalla MA, Yousri RM, Abdelkader-RM, El-Tayeb TA, Bakr M, Happ CS, Abdelaziz AI and Abdel-Kader MH :EASL special conference, Hepatocellular carcinoma: from Genomics to treatment, Dubrovnik, Croatia, 2010.
Conference 2010	Baclofen brain targeting: high CNS levels via baclofen methyl carbamate Salwa Mosaad, Raimund Niess, Khaled Abou-Zeid, Rasha Hanafi, Reham Abdel-kader, Hilde Spahn-Langguth : 9th international meeting of the society of study of xenobiotics, Istanbul,, 2010.

2009

Journal 2009

Fundamentals of therapeutic application of EGb 761. Müller WE, Abdel-Kader R, Fehske CJ, Leuner K. (2009) Pharm Unserer Zeit. 38(5):408-16

2007

Workshop 2007	Ginkgo biloba extract (EGb 761®) protects mitochondrial functions in both non-transgenic and APP transgenic mice R. Abdel-Kader, U. Keil, K. Leuner and W. E. Müller :, ISAO Workshop (Current aspects in the field of Alzheimer's Research), 2007.
Conference 2007	Ginkgo biloba extract (EGb 761®) protects mitochondrial functions in vitro and ex vivo Oral presentation R. Abdel-Kader : Young Researcher Meeting, Muenster Germany, 2007.
Journal 2007	Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment Franke, C., Noldner, M., Abdel-Kader, R., Johnson-Anuna, L. N., Gibson, W. W., Muller, W. E. and Eckert, G. P. : , Neurobiol.Dis. 25, 438-445, 2007.
Journal 2007	Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761®). Abdel-Kader, R., Hauptmann, S., Keil, U., Scherping, I., Leuner, K., Eckert, A. and Muller, W. E. (2007) Pharmacol.Res., 56, 493-502. IF:4.408*
Journal 2007	Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Leuner, K., Hauptmann, S., Abdel-Kader, R., Scherping, I., Keil, U., Strosznajder, J. B., Eckert,A. and Muller, W. E. (2007)Antioxid.Redox.Signal., 9, 1659-1675 IF 7.407

2006

Conference 2006	Protective effects of Ginkgo biloba extract in different animal models R. Abdel-Kader, I. Scherping, S. Hauptmann, U. Keil, W. E. Müller : ,47th Spring Meeting DGPT, Mainz, Germany, 2006.
Conference 2006	Stabilization of mitochondrial function by Ginkgo biloba extract Abdel-Kader, R., Scherping, I., Hauptmann, S., Keil, U. and Müller, W. E: ,Neuroscience society’s 36th annual meeting Atlanta, Ga, USA, 2006.

2005

Conference 2005

Mitochondrial protection using Ginkgo biloba extract (EGb 761®) in vitro and in vivo using several animal models
R. Abdel-Kader, I. Scherping, S. Hauptmann, U. Keil, W. E. Müller :, 4th Mitochondrial physiology conference [MiP] , Schroecken, Austria, 2005.

Prof. Lobna Abdelaal Kassem

Email: lobna.abdelaal@guc.edu.eg
Office:B5-125
Ext:3403

Biography

Lobna Kassem is a full professor of Physiology at the German University in Cairo. She joined the GUC in 2004 and she had been the head of department of pharmacology and toxicology from 2014 until 2019. She earned her doctoral degree in 1998 from faculty of Medicine-Cairo University and promoted to professor in 2009. She joined Juntendo University, Tokyo-Japan; as fellow researcher and worked on cardiac ion channels. She was the main supervisor of more than 20 PhD and master theses. She is peer reviewer in different scientific journals; eg. DNA and cell biology; Brain Research Bulletin; Nutritional neuroscience; Drug discoveries and Therapeutics. During her academic career, she participated in many national and international conferences. She established collaboration with “Institut Fur neurophysiologie der Universitat Zu Koln” in the field of regenerative medicine. She is also collaborating with some professors in department of neurology, Ulm University in the field of neurodegenerative disorders. She organized many research internships for students.

Research Interests

Her research field is mainly exploring the underlying pathophysiology and new trends in treatment of Alzheimer’s disease (AD) targeting different signaling pathways. Her current research project is developing a specific diagnostic exosomal marker for earlier and accurate clinical diagnosis of AD. This is in collaboration with department of neurology, Ulm University. Regenerative medicine is also one of her important fields of study with the potential use of gene therapy and stem cell therapy in different diseases such as AD, diabetic cardiomyopathy and skeletal myopathy. She is also interested in Chemotherapy induced central neurotoxicity and their influence on neurotransmitters’ level namely serotonin and offers research internships for students in this field. Lastly, the potential therapy of peripheral neuropathies using natural compounds and their effects on neurophysiological function such as action potential is established and running in the physiology lab.

Publications

2016

Journal 2016	The Effect of Thymoquinone, α7 Receptor Agonist and α7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation. Ibrahim AbdEl Fattah L1, Zickri MB1, Aal LA1, Heikal O1, Osama E2 Int J Stem Cells. 2016 Nov 30;9(2):230-238
Journal 2016	Activation of Migration of Endogenous Stem Cells by Erythropoietin as Potential Rescue for Neurodegenerative Diseases • M.I. Khairallah , L.A. Kassem , N.A. Yassin , M. Attia. Brain Res Bull. 2016 Mar; 121:148-57.

2014

Journal 2014	Exercise training restores the regenerative potential of injured skeletal muscle via activation of endogenous stem cells. L. Kassem, N. EL Hadary, M. Zikri Clinical neurophysiology. June 2014 (125), Supplement 1, Page S31
Journal 2014	The hematopoietic growth factor "erythropoietin" enhances the therapeutic effect of mesenchymal stem cells in Alzheimer's disease. M I Khairallah, L A Kassem, N A Yassin, M A Gamal El Din, M Zekri, M Attia Pakistan Journal of Biological Sciences 01/2014; 17(1):9-21.

2013

Journal 2013

Modulation of Skeletal Muscle Performance and SERCA by Exercise and Adiponectin Gene Therapy in Insulin-Resistant Rat. Safwat Y1, Yassin N, Gamal El Din M, Kassem L. DNA and cell biology 07/2013; 32(7):378-85.

2011

Journal 2011	Mechanisms of vincristine-induced neurotoxicity: Possible reversal by erythropoietin. L A Kassem, M M Gamal El-Din, N A Yassin Drug Discov Ther. 06/2011; 5(3):136-43.
Journal 2011	Alzheimer's disease: current status of etiopathogenesis and therapeutic strategies. Khairallah MI1, Kassem LA. Pak J Biol Sci. 2011 Feb 15;14(4):257-72
Journal 2011	Antiapoptotic effect of DDB against hepatic ischemia-reperfusion injury. El-Bahy AA1, Kassem LA, Heikal OA, Mahran LG. J Toxicol Sci. 2011 Apr;36(2):145-54.

2010

Journal 2010

Role of erythropoeitin in prevention of chemotherapy-induced peripheral neuropathy. Kassem LA1, Yassin NA Pak J Biol Sci. 2010 Jun 15;13(12):577-87

2009

Journal 2009	Promising therapy for Alzheimer's disease targeting angiotensinconverting enzyme and the cyclooxygense-2 isoform. N S El Sayed, L A Kassem, O A Heikal Drug Discov Ther. 2009; 3(6):307-315.
Journal 2009	Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury R M Abd El-Ghany, N M Sharaf, L A Kassem, L G Mahran, O A Heikal Drug Discov Ther. 12/2009; 3(6):296-306.

2008

Journal 2008

Mechanisms of ischemic postconditioning-induced hepatoprotection: Role of the permeability transition pore and the mitochondrial F1-F0 ATPase L. A. Kassem, O. A. Heikal Journal of Hepatology 01/2008; 48.

2004

Journal 2004

Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes. Haidara MA1, Khloussy H, Ammar H, Aal Kassem LA. Med Sci Monit. 2004 Feb;10(2):BR41-6.

2001

Journal 2001

K-ATP channel inhibitors paradoxically facilitate recovery from superoxide-induced myocardial depression Takao Okada, Lobna Kassem, Sachin A. Gupte, Makino Watanabe Journal of Molecular and Cellular Cardiology 06/2001; 33(6).

Prof. Nabila Hamdi

Email: nabila.hamdi@guc.edu.eg
Office:B3.114
Ext:3402

Biography

Nabila Hamdi is currently an Associate Professor of Molecular Pathology and the head of the Molecular Pathology Unit at GUC. She graduated from the Medical University in Sfax, Tunisia. She obtained her degree of Doctor in Medicine in 1999 upon the accomplishment of a thesis in Pediatric Genetics with excellence. She spent the practical years of her clinical rotation at Ludwig Maximillian University (LMU) Munich, Germany. She joined the GUC in 2007 as Senior Teaching Assistant of Pathology and Pathophysiology, and received a Ph.D. degree in Molecular Genetics Pathology in 2009. During her post-doctoral period, she spent several research stays in Germany to extend her research experience. Nabila Hamdi has supervised more than 20 Master and PhD projects and has more than 40 publications, including journal papers, proceedings and conferences. In addition, she has organized several workshops and conferences and has earned several funds.

Research Interests

Her current research interest is in the field of neuroscience, focusing on the role of neuroinflammation in brain disorders, mainly in neurodegeneration, and the genetic/epigenetic aspects of neurodegenerative diseases. Within this frame work, Nabila Hamdi has established a strong collaboration with the Neurology Department at Ulm University in Germany as well as well as the Neurology Department at Ain Shams University in Cairo with common projects and co-supervisions.

Publications

2023

Journal 2023	Soliman, R., Rashed, H. R., Moustafa, R. R., Hamdi, N., Swelam, M. S., Osman, A., & Fahmy, N. (2023). Egyptian adaptation and validation of the Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen (ECAS-EG). Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, https://doi.org/10.1007/s10072-023-06639-6
Journal 2023	Fahmy, N., Müller, K., Andersen, P. M., Marklund, S. L., Otto, M., Ludolph, A. C., & Hamdi, N. (2023). A novel homozygous p.Ser69Pro SOD1 mutation causes severe young-onset ALS with decreased enzyme activity. Journal of neurology, 270(3), 1770–1773. https://doi.org/10.1007/s00415-022-11489-x
Journal 2023	Reham Ahmed Wagdy; Reham M. Abdel-Kader; Ahmed H. El-Khatib; Michael W. Linscheid; Heba Handoussa; Nabila Hamdi. Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study. BMC Complement Med Ther 23, 165 (2023). https://doi.org/10.1186/s12906-023-03994-x

2022

Conference 2022	Nora Badawy, Nabila Hamdi, Reham Abdel-Kader. THE ROLE OF ESTRADIOL-DEPENDENT MITOCHONDRIAL BIOGENESIS IN THE COGNITIVE ENHANCEMENT EFFECTS OF METHYLENE BLUE. AD/PD™ 2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders. March 15-20, 2022. Barcelona, Spain.
Conference 2022	Omar Rashad, Salma Tammam, Nabila Hamdi, Emad Shash, Samar Mansour. Different serum, different corona! How reliable are in-vitro nanoparticle uptake experiments conducted in the presence of bovine serum? 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 28 - 31 March 2022 \| Rotterdam, The Netherlands
Conference 2022	Alaa Selim, Rami Al Shweiki, Lobna Kassem, Nabila Hamdi, Markus Otto. COMBINED IMMUNOPRECIPITATION AND POLYMER-BASED PRECIPITATION FOR THE ISOLATION OF SERUM-DERIVED EXOSOMES. 16th World Congress on Controversies in Neurology (CONy), March 24-27, 2022.
Conference paper 2022	Mariz Awad, Jailan Salah, Slim Abdennadher, Nabila Hamdi. A-Learning: A Computerized Adaptive Learning Expert System. CSEDU, the International Conference on Computer Supported Education. 22-24 April, 2022.
Conference 2022	Healthy aging of serum/plasma microRNA profiles is impaired in ALS. Non-coding RNA in MND/ALS Meeting at ENCALS 2022. 1-3 June 2022 McEwan Hall, Edinburgh, Scotland. Talk
Conference 2022	Discovery of Novel Allosteric CCR9 Ligands as Anticolorectal Cancer Agents by Sequential Virtual Screening. 4GPCRNET INTERNATIONAL SYMPOSIUM 2022, September 26-29, 2022, Leipzig, Germany.

2021

Conference 2021	N. Fahmy, K. Müller, P. Andersen, S. Marklund, A. Ludolph, N. Hamdi. EP.243 Young-onset SOD1-ALS caused by a novel homozygous mutation, a family report. World Muscle Society Virtual Congress, 20-24 September 2021. Neuromuscular Disorders. VOLUME 31, SUPPLEMENT 1, S122-S123, OCTOBER 01, 2021. DOI:https://doi.org/10.1016/j.nmd.2021.07.267
Conference 2021	Alaa Selim, Rami Alshweiki, Nabila Hamdi, Lobna Kassem, Markus Otto. "Evaluation of a combined polymer and size exclusion chromatography-based protocol for the isolation of serum-derived exosomes”. 15th World Congress on Controversies in Neurology (CONy), September 23-26, 2021
Conference 2021	Hams Ibrahim, Reham Mahmoud Abdelkader, Nabila Hamdi and Ola Ahmed Heikal. Effect of Rice Bran Extract in Neuroinflammation through PPAR gamma receptor in Microglial cell line. Closing Conference of the INTEGRATED PHARMACEUTICAL ALLIANCE: Towards Development of Technology-based Egyptian Pharmaceutical Products. September 19, 2021, Grand Nile Tower Hotel, Cairo.

2019

Journal 2019	Neuromodulatory activity of dietary phenolics derived from Corchorus olitorius L. Wagdy R, Abdel-kader R.M, El-Khatib A.H,.Linscheid M.W, Hamdi H, Handoussa H. Journal of Food Science Vol. 84, Iss. 5, 24 April, 2019.
Journal 2019	Magnetic Localization and Control of Helical Robots for Clearing Superficial Blood Clots. Khalil I.S.M, Adel A, Mahdy D, Micheal M.M, Mansour M, Hamdi N, and Misra S. APL Bioengineering 3, 026104 (2019);"Top Cited Articles from APL Bioengineering"
Conference Paper 2019	Characterization of Helical Propulsion Inside In Vitro and Ex Vivo Models of a Rabbit Aorta. Mahdy D, Hesham S, Mansour M, Mohamed A, Basla I, Hamdi N. 41st International Engineering in Medicine and Biology Conference, Berlin, Germany, July 23–27, 2019
Conference Paper 2019	PathoGenius VR: VR Medical Training. Makled E, Yassien A, Elagroudy P, Magdy M, Abdennadher S, Hamdi N. PerDis '19: Proceedings of the 8th ACM International Symposium on Pervasive Displays. June 2019 Article No.: 31 Pages 1–2. https://doi.org/10.1145/3321335.3329694

2018

Journal 2018	Ultrasound-Guided minimally invasive grinding for clearing blood clots: promises and challenges. Mahdy D, Reda R, Hamdi N,. Khalil I. S. M. IEEE Instrumentation & Measurement Magazine, vol. 21, no. 2, pages 10-14, April 2018
Journal 2018	Mechanical rubbing of blood clots using helical robots under ultrasound guidance. Khalil I. S. M., Mahdy D, El Sharkawy A, Moustafa R. R., Tabak A. F., Elwi M, Hesham S, Hamdi N, Klingner A, Mohamed A, Sitti M. IEEE Robotics & Automation Letters (RAL), vol. 3, no. 2, pages 1112-1119, April 2018.
Conference Paper 2018	The influence of mechanical rubbing on the dissolution of blood clots. Mahdy D, Hamdi N, El Sharkawy A, Hesham S,. Khalil I. S. M. In Proceedings of the International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, USA, July 2018. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1660-1663.

2017

Journal 2017	Rubbing Against Blood Clots Using Helical Robots: Modeling and In Vitro Experimental Validation. I. S. M. Khalil, A. F. Tabak, K. Sadek, D. Mahdy, N. Hamdi and M. Sitti, in IEEE Robotics and Automation Letters, vol. 2, no. 2, pp. 927-934, April 2017, doi: 10.1109/LRA.2017.2654546.
Conference Paper 2017	Independent control of nanoparticle cluster. Alaa M, Klingner A, Hamdi N, Abdennadher S, and. Khalil I. S. M. In Proceedings of the International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M Nano), Shanghai, China, pages 358-363, August 2017 (Best Student Conference Paper Award).
Conference Paper 2017	Experimental Characterization of Helical Propulsion in Newtonian Fluids and Viscoelastic Environments. Mahdy D, Mohamed A, Hamdi N, Tammam A, Wahdan A, Serry M, Khalil I.S.M. The International Conference IEEE 3M-NANO, 7-11 August 2017 Shanghai, China.
Conference Poster 2017	Natural products as drug leads for neurodegenerative diseases; Alzheimer and Dementia. Handoussa H, Wagdy R, Selim A, Abdel-Kader R.M, Hamdi N, El Sayed N. 8th World Congress on Toxicology and Pharmacology. April 13-15, 2017 Dubai, UAE. Toxicol Open Access 2017
Conference Poster 2017	Nutraceuticals as Drug Leads for Alzheimer Disease. Wagdy R, Abdel-kader R.M, El-Khatib A, Linscheid M, Hamdi N, Handoussa H. Conference of German-Egyptian Network for Innovation and Development (GENID) funded by the Alexander von Humboldt Foundation, 22-23 February 2017, Cairo, Egypt
Conference Paper 2017	PathoGenius: A Serious Game for Medical Courses. Ashry M, Abdennadher S, Hamdi N, Aboelazm A. In: Alcañiz M., Göbel S., Ma M., Fradinho Oliveira M., Baalsrud Hauge J., Marsh T. (eds) Serious Games. JCSG 2017. Lecture Notes in Computer Science, vol 10622. Springer, Cham. http://doi-org-443.webvpn.fjmu.edu.cn/10.1007/978-3-319-70111-0_9

2016

Journal 2016	Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer's Disease Mouse Model. Zakaria A, Hamdi N, Abdel-Kader RM. Mol Neurobiol.2016 Mar;53(2):1220-8.
Conference Poster 2016	In Vitro Validation of Clearing Clogged Vessels using Microrobots. Hosney A, Abdalla J, Amin I.S, Hamdi N, Khalil I.S.M. 6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob), June 26-29, 2016. UTown, Singapore.

2015

Journal 2015	Minocycline attenuates Aß oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aß fibrils phagocytosis El-Shimy I.A, Heikal O. and Hamdi N : Minocycline attenuates Aß oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aß fibrils phagocytosis , Neuroscience Letters, Volume 609, 16 November 2015, Pages 36–41, 2015.
Conference Poster 2015	Dasatinib modulates M1/M2 polarization and improves cognitive deficits in a mouse model of neuroinflammation. El-Sallab H.T, Abdel-Kader R.M and Hamdi N. The 12th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (AD/PDTM 2015)”, March 18-22, 2015 Nice, France.
Conference Poster 2015	Investigation of genetic recombination of hepatitis C virus in patients infected with genotypes 1, 2 and 4. Dietz J, Hamdi N, Susser S, Peiffer K.-H, Berkowski C, Perner D, Zeuzem S, Sarrazin C. EASL, the 50th International Liver Congress 2015, April 22-26, Vienna, Austria. Hepatology, April 2015 Volume 62, Supplement 2, Page S597

2014

Conference Poster 2014	Minocycline suppresses M1 microglia activation while enhancing phagocytosis of Aß fibrils El-Shimy I.A, Heikal O. and Hamdi N : Minocycline suppresses M1 microglia activation while enhancing phagocytosis of Aß fibrils , 8th International Symposium on Neuroprotection Neurorepair 2014, The Magdeburg Meeting Series, 2014.
Journal 2014	Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV Fawzy I.O, Ahmed R, Esmat G, Hamdi N, Abdelaziz A.I : Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV , Journal of Medical Virology, 2014.
Conference Poster 2014	Transfersomal Chlorophyllin Derivatives: A Novel Model in the Photodynamic Treatment of Malignant Brain Tumors Attia N.A, Hamdi N, Mansour S, Abdel-Kader M.H. : Transfersomal Chlorophyllin Derivatives: A Novel Model in the Photodynamic Treatment of Malignant Brain Tumors , 2014 ASP Annual Meeting, 37TH AMERICAN SOCIETY FOR PHOTOBIOLOGY, San Diego, CA, 2014.
Journal 2014	Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C Susser S, Herrmann E, Lange C, Hamdi N, Muller T, Berg T, Perner D, Zeuzem S, Sarrazin C : Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C , PLoS ONE, Nov 9(11) , 2014.
Conference Poster 2014	Predictive value of the interferon-lambda 4 gene (IFN-L4) for direct-/antiviral treatment in hepatitis C virus infected patients with genotypes 1, 2, 3, and 4. Susser S, Lange C.M., Hamdi N, Berg T, Perner D, Zeuzem S, Sarrazin C. EASL - The International Liver Congress 2014, 49th Annual Meeting of the European Association for the Study of the Liver London, United Kingdom, April 9-13. P732 Journal of Hepatology 60(1):S314·

2013

Journal 2013	Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in PBMCs of HCV-infected Egyptian patients Tayel S.S, Helmy A.A, Ahmed R, Esmat G, Hamdi N1 and Abdelaziz A.I: Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in PBMCs of HCV-infected Egyptian patients , Arch Virol, 2013.
Conference Poster 2013	Role of Grape Seed Extract in Lipopolysaccharide induced Alzheimer's Disease Model: Possible Implication on Amyloid Beta Formation. Al Shehaby N.A.H., Heikal O, Hamdi N, El Sayed N.S. XX World Congress on Parkinson’s Disease and Related Disorders, 8-11 December 2013, Geneva Switzerland
Conference Poster 2013	Photodynamic Therapy of Malignant Brain Tumors Using Natural Chlorophyllin Derivatives. Attia N.A, Hamdi N, Abdel-Kader M.H. International Conference on Natural Products Utilization, from Plants to Pharmacy Shelf, Bansko, Bulgaria, 3-6 November 2013.
Conference Poster 2013	Metabolic modeling of glioblastoma subtypes. Mohamed A, Sharma A.K, Piro R.M, Oswald M, Plaimas K, Hamdi N, El Bordeiny A, Breitinger H, Toenjes M, Radlwimmer B, Roland Eils, Rainer Koenig. Joint 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and 12th European Conference on Computational Biology (ECCB) 2013, 19 - 23 Jul 2013
Conference Poster 2013	Thymoquinone improves cognitive function and increases α -7nAChRs expression in a rat model of neuroinflammation. Heikal O, El.Mennawy S, Hamdi N and EL Sayed N.S. XXIst Congress of Neurology, Vienna, Austria, September 2013. Journal of Neurological Sciences. October 15, 2013, Journal of Neurological Sciences, Volume 333, Supplement 1, Pages e342–e343. DOI: http://dx.doi.org/10.1016/j.jns.2013.07.12631
Conference Poster 2013	Methylene blue decreases brain mitochondrial ABAD and amyloid beta levels protecting mitochondrial functions in LPS-mouse model. Abdel-Kader R.M., Zakaria A., Hamdi N. Mol Neurodegeneration 8, P1 (2013). https://doi.org/10.1186/1750-1326-8-S1-P1
Conference Poster 2013	Subtypisierung von Hepatitis C Virus Genotyp 4 Proben – Signifikante Unterschiede zwischen INNO-LiPA und Sequenzierung von NS5B. Susser S, Perner D, Hamdi N, Zeuzem S, Sarrazin C. Zeitschrift für Gastroenterologie 2013; 51 - P_5_66 DOI: 10.1055/s-0032-1332180

2012

Journal 2012	Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients Mekky R.Y, Hamdi N, El-Akel W, Esmat G and Abdelaziz A.I :Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients , Translational Research, 2012. 2012 Mar;159(3):190-6
Journal 2012	Hepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication von Hahn T, Schiene-Fischer C, Pfänder S, Karavul B, Steinmann E, Potthoff A, Strassburg C, Hamdi N, Abdelaziz A.I, Sarrazin C, Müller T, Berg T, Trépo E, Wedemeyer H, Manns M.P, Pietschmann T and Ciesek S : Hepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication , Gatroenterology, 2012.
Journal 2012	Transcriptional Repression of Interferon-Related microRNAs, miR-146a and miR-155, in HCV Genotype 4 Infected PBMCs El-Ekiaby N; Hamdi N; Negm M; Ahmed R; Zekri AR; Esmat G; Abdelaziz AI : Transcriptional Repression of Interferon-Related microRNAs, miR-146a and miR-155, in HCV Genotype 4 Infected PBMCs, FEBS Open Bio, 2012.
Journal 2012	Induced Inhibition of the Interferon Signaling Pathways in PBMCs of Infected Females Fawzy I.O, Ahmed R, Esmat G, Hamdi N, Abdelaziz A.I : Induced Inhibition of the Interferon Signaling Pathways in PBMCs of Infected Females , J Viral Hepat, 2012.
Journal 2012	Potent Inhibitory Effects of p7 Inhibitors on Genotype 4 HCV-infected Peripheral Blood Mononuclear Cells Saleh MA, Mekky RY, El-EKiaby N, Hamdi N, Ahmed R, Zekri AR, Esmat G, Abdelaziz AI : Potent Inhibitory Effects of p7 Inhibitors on Genotype 4 HCV-infected Peripheral Blood Mononuclear Cells , Recent Patents on Biomarkers , 2012.
Journal 2012	Repressed induction of interferon-related microRNAs miR-146a and miR-155 in peripheral blood mononuclear cells infected with HCV genotype 4. El-Ekiaby N,Hamdi N, Negm M, Ahmed R, Zekri AR, Esmat G, Abdelaziz AI. FEBS Open Bio. 2012 Jul 20;2:179-8.Repressed induction of interferon-related microRNAs miR-146a and miR-155 in peripheral blood mononuclear cells infected with HCV genotype 4. El-Ekiaby N,Hamdi N, Negm M, Ahmed R, Zekri AR, Esmat G, Abdelaziz AI. FEBS Open Bio. 2012 Jul 20;2:179-8.
Journal 2012	Transcriptional response of MxA, PKR and SOCS3 to interferon-based therapy in HCV genotype 4-infected patients and contribution of p53 to host antiviral response. Hamdi N, El-Akel W, El-Serafy M, Esmat G, Sarrazin C, Abdelaziz AI. Intervirology. 2012;55(3):210-8..

2011

Journal 2011	Development of a Second Version of the Cobas AmpliPrep/Cobas TaqMan Hepatitis C Virus Quantitative Test with Improved Genotype Inclusivity. Vermehren J, Colucci G, Gohl P, Hamdi N, Abdelaziz A.I, Karey U, Thamke D, Zitzer H, Zeuzem S, and Sarrazin C. J Clin Microbiol. 2011 Sep;49(9):3309-15.
Journal 2011	Impact of Intra- and Interspecies Variation of Occludin on Its Function as Coreceptor for Authentic Hepatitis C Virus Particles. Ciesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, Hamdi N, Abdelaziz A.I, Strassburg C.P, Wedemeyer H, Manns M.P, Pietschmann T and von Hahn T. J Virol. 2011 Aug;85(15):7613-21.
Conference Poster 2011	Modulation of the HCV replication cycle by genetic variation in the PPIA gene encoding the essential host factor cyclophilin A. von Hahn T, Karavul B, Steinmann E, Potthoff A, Strassburg C, Wedemeyer H, Hamdi N, Abdelaziz A.I, Sarrazin C, Müller T, Berg T, Manns M.P, Pietschmann T and Ciesek S. AASLD Annual Meeting 2011, San Francisco.

2009

Conference poster 2009	A missing correlation between the number and type of MEFV mutations and severity of FMF clinical manifestations. Salah S, Mokhtar Y, Hamdi N and Abdelaziz A. I. 18th IFCC – EFCC European Congress of Clinical Chemistry and Laboratory Medicine 7 – 11 June 2009, Innsbruck, Austria. Clin Chem Lab Med, 2009. 47 special supplement
Conference Poster 2009	Potential antiviral role of p53 in HCV-infected patients. Hamdi N, El-Serafy M, Esmat G, Alaakel W and Abdelaziz A.I. The 34th FEBS Congress. July 4-9, 2009. Prague, Czech Republic. FEBS Journal, 2009. 276 (1): p. 312. doi: 10.1111/j.1742-4658.2009.07045.x.

Assoc. Prof. Hend El Tayebi

Email: hend.saber@guc.edu.eg
Office:B5-112
Ext:

Biography

With 13 years experience in the academic and research fields, El Tayebi is an assistant professor of Molecular Toxicology and Pharmacoeconomics and she is leading the “Molecular Pharmacology Research Group-MPRG” in the faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Egypt.

El Tayebi received her B.Sc. degree with highly honored excellence from faculty of Pharmacy and Biotechnology, GUC, in 2008. In 2009, she has been appointed as assistant lecturer of molecular pathology and pathophysiology at the GUC. And in 2014, she started teaching Cell Biology and Genetic Engineering as an assistant professor.

She pursued her M.Sc. and PhD studies in the field of Molecular Pharmacology in the period from 2008-2012. She received her PhD degree with “Summa cum laude” from the GUC in collaboration with the institute of Pathology, Heidelberg, Germany in 2012.

Hend established the Molecular Pharmacology research group- MPRG at the GUC in 2015. The MPRG focuses on pharmacogenomics of tumors and autoimmune diseases via epigenetic and molecular immuno-regulation of certain immuno-modulatory proteins in different cancers as well as autoimmune diseases such as Multiple Sclerosis. El Tayebi has supervised 20+ MSc. And PhD projects as well as B.Sc biotechnology project. The research group is composed of 2 PhD student, 20 M.Sc. students, 2 B.Sc. students and 10 undergraduate interns. MPRG is collaborating with several research groups worldwide in Germany, Netherlands and USA.

Through out her academic career, Hend has been invited as a guest speaker in more than 10 international conferences in Europe and MENA region, published and presented her research work in 30+ international conferences in Europe and USA (EASL, AASLD, Falling Wall of Berlin, ESMO, EMBO and more) and she has published 20+ paper publications in a high impact peer-reviewed international journals.

In 2015, She has pursued her MBA studies at the German university in Cairo with a double major of “International Business” and “Strategic Management”. Additionally, she studied Health Economics and research outcome in Utrecht university, the Netherlands in addition to the Arab Academy for Science and Transportation-AAST, Egypt where she received a diploma in health economics studies from. El Tayebi has been awarded the AAST award for achieving the 1st Rank on all AAST diploma programs in February 2020.

Research Interests

The Molecular Pharmacology Research Group focuses on genetic and epigenetic immunooncology and molecular regulation of certain immuno-modulatory proteins in liver and breast cancer as well as autoimmune diseases such as Multiple Sclerosis (MS). The team collaborates with several departments in the faculty of pharmacy and biotechnology at the GUC such as pharmaceutical biology (investigating the role of novel nutraceuticals on diseases epigenome), pharmaceutical chemistry (pharmacologic screening, testing and evaluation of novel compounds) and pharmaceutical technology (establishment of novel delivery systems and targeted therapies). El Tayebi has received several funds from DAAD and STDF.

Publications

2023

Journal 2023	MicroRNA 155 modulation of CD8+ T cell activity personalizes response to disease modifying therapies of patients with relapsing remitting multiple sclerosis. Elkhodiry AA, Zamzam DA, El Tayebi HM.Med Int (Lond). 2023 Mar 20;3(2):20. doi: 10.3892/mi.2023.80. eCollection 2023 Mar-Apr.PMID: 37032715 Free PMC article.
Journal 2023	Rs205764 and rs547311 in linc00513 may influence treatment responses in multiple sclerosis patients: A pharmacogenomics Egyptian study. Amin NS, Abd El-Aziz MK, Hamed M, Moustafa RR, El Tayebi HM.Front Immunol. 2023 Feb 17;14:1087595. doi: 10.3389/fimmu.2023.1087595. eCollection 2023.PMID: 36883100
Journal 2023	More gain, less pain: How resistance training affects immune system functioning in multiple sclerosis patients: A review. Amin NS, El Tayebi HM.Mult Scler Relat Disord. 2023 Jan;69:104401. doi: 10.1016/j.msard.2022.104401. Epub 2022 Nov 12.PMID: 36403379 Review.
Grant 2023	“Comprehensive screening and in-vitro analysis of PD-L1 small molecule inhibitors on a myriad of solid tumors: Hepatocellular carcinoma, colon cancer, pancreatic cancer and triple negative breast cancer” funded by the DAAD-BMBF
Grant 2023	Screening of Resistance- and Relapse-related Single Nucleotide Polymorphism in Hepatocellular Carcinoma Patients. (Project ID: 46300) Funded by the STDF
Grant 2023	Multi-dimensional screening of potential PD-1/PD-L1 immune checkpoint inhibitors as anti- hepatocellular carcinoma agents.” funded by ASRT

2022

Journal 2022	NEAT1: Culprit lncRNA linking PIG-C, MSLN, and CD80 in triple-negative breast cancer. Hussein NH, Eissa RA, de Bruyn M, El Tayebi HM.Life Sci. 2022 Jun 15;299:120523. doi: 10.1016/j.lfs.2022.120523. Epub 2022 Apr 2.PMID: 35378140
Journal 2022	CXCR2 Small-Molecule Antagonist Combats Chemoresistance and Enhances Immunotherapy in Triple-Negative Breast Cancer. Ghallab AM, Eissa RA, El Tayebi HM.Front Pharmacol. 2022 Apr 20;13:862125. doi: 10.3389/fphar.2022.862125. eCollection 2022.PMID: 35517812
Journal 2022	A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach. Amer HT, Eissa RA, El Tayebi HM.Front Mol Biosci. 2022 Oct 28;9:1032517. doi: 10.3389/fmolb.2022.1032517. eCollection 2022.PMID: 36387279
Journal 2022	The Monocyte, a Maestro in the Tumor Microenvironment (TME) of Breast Cancer. Amer HT, Stein U, El Tayebi HM.Cancers (Basel). 2022 Nov 7;14(21):5460. doi: 10.3390/cancers14215460.PMID: 36358879
Journal 2022	Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges. Kamal MA, Mandour YM, Abd El-Aziz MK, Stein U, El Tayebi HM.Molecules. 2022 Aug 28;27(17):5537. doi: 10.3390/molecules27175537.PMID: 36080304

2021

Grant 2021	Principle investigator of Academy of Scientific Research and Technology (ASRT) fund for project entitled: “Multi-dimensional screening of potential PD-1/PD-L1 immune checkpoint inhibitors as anti- hepatocellular carcinoma agents.” Proposal accepted in May 2021
Grant 2021	Principle investigator of DAAD/BMBF grant in collaboration with Prof. Ulrike Stein (Charite and Max-Delbruck Centre, Berlin, Germany). Project entitled: “CXCR2 Small Molecule Inhibitors: a Novel Approach to Combat Chemo-resistance and Augment Immunotherapy in Triple Negative Breast Cancer” Proposal accepted in December 2021.
Journal 2021	From Whole Blood to Isolated Pro-Metastasis Immune Cells: An Ex Vivo Approach to Isolate and Manipulate Immune Cells Contributing to Tumor Metastasis. Samir A, El Khodiry AA, ElTayebi HM. Methods Mol Biol. 2021 ;2294:209-218. doi: 10.1007/978- 1- 0716-1350-4_15.PMID: 33742404
Journal 2021	Oleuropin controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology. Hamed MM, Handoussa H, Hussein NH, Eissa RA, Abdel-Aal LK, El Tayebi HM.Life Sci. 2021 Mar 30;277:119353. doi: 10.1016/j.lfs.2021.119353. Online ahead of print.PMID: 33798547
Journal 2021	miR-155 and functional proteins of CD8+ T cells as potential prognostic biomarkers for relapsing-remitting multiple sclerosis Aya A Elkhodiry, Dina A Zamzam, Hend M El Tayebi , Mult Scler Relat Disord. 2021 Aug;53:103078. doi: 10.1016/j.msard.2021.103078. Epub 2021 Jun 11.
Journal 2021	Long non-coding RNAs XIST and MALAT1 hijack the PD-L1 regulatory signaling pathway in breast cancer subtypes. Samir A, Tawab RA, El Tayebi HM.Oncol Lett. 2021 Aug;22(2):593. doi: 10.3892/ol.2021.12854. Epub 2021 Jun 7.PMID: 34149904
Journal 2021	Genetic Heterogeneity, Therapeutic Hurdle Confronting Sorafenib and Immune Checkpoint Inhibitors in Hepatocellular Carcinoma. Atwa SM, Odenthal M, HM El Tayebi.Cancers (Basel). 2021 Aug 27;13(17):4343. doi: 10.3390/cancers13174343.PMID: 34503153
Journal 2021	Scavenging the hidden impacts of non-coding RNAs in multiple sclerosis.Elkhodiry AA, El Tayebi HM.Noncoding RNA Res. 2021 Dec 7;6(4):187-199. doi: 10.1016/j.ncrna.2021.12.002. eCollection 2021 Dec.PMID: 34938929
Journal 2021	Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients? Elgohary S, Elkhodiry AA, Amin NS, Stein U, El Tayebi HM.Cells. 2021 Feb 2;10(2):302. doi: 10.3390/cells10020302.PMID: 33540625
Conference 2021	CXCR2 Small Molecule Antagonists: a Novel Approach to Enhance the Effect of PDL-1 Inhibitors in Triple Negative Breast Cancer, ESMO Breast Cancer Virtual Congress, May 2021. Alaa Ghallab , Reda A. Eissa and Hend M. El Tayebi
Conference 2021	CXCR2 Antagonist Revoked TGF- β Elevation in Chemo-resistant Triple Negative Breast Cancer Cells. ESMO ImmunOncology Conference, Geneva, December 2021 Alaa Ghallab, Reda Eissa, Hend M. El Tayebi
Conference 2021	Combined efforts of LncRNAs DILC and Atezolizumab to regulate MMP-9 release in tumor microenvironment of TNBC TAMs and cells lines. ESMO ImmunOncology Conference, Geneva, December 2021. Amany Samir, Reda Eissa, Ulrike Stein, Hend M. El Tayebi
Conference 2021	Paracrine Crosstalk between LncRNA DILC and TNF-α release in tumor microenvironment of triple negative breast cancer Amany Samir, Reda Eissa, Ulrike Stein, Hend M. El Tayebi. ESMO ImmunOncology Conference, Geneva, December 2021

2020

Journal 2020	LncRNAs; XIST and MALAT1 hijack PD-L1 regulatory pathway in breast cancer subtypes. Amany Samir, Reda A. Eissa and Hend M. El Tayebi, Oncology Letters, December 2020 (In production and Proofreading)
Journal 2020	GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets Nada H. Hussein, Nada S. Amin and Hend M. El Tayebi* , Front. Oncol., 04 December 2020 \| https://doi.org/10.3389/fonc.2020.537311
Journal 2020	Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma. Sara M Atwa, Heba Handoussa, Karim M Hosny, Margarete Odenthal and Hend M El Tayebi, World Journal of Hepatology, October 2020 (ahead of print)
Journal 2020	MALAT-1: LncRNA ruling miR-182/PIG-C/mesothelin triad in triple negative breast cancer. Barsoum FS, Awad AS, Hussein NH, Eissa RA, El Tayebi HM.Pathol Res Pract. 2020 Nov 4;216(12):153274. doi: 10.1016/j.prp.2020.153274. Online ahead of print.PMID: 33171372
Journal 2020	XIST and TSIX: Novel Cancer Immune Biomarkers in PD-L1-Overexpressing Breast Cancer Patients Esraa A Salama, Reda E Adbeltawab, Hend M El Tayebi, Front Oncol, 9, 1459 2020 Jan 10. PMID: 31998636, PMCID: PMC6966712 DOI: 10.3389/fonc.2019.01459
Journal 2020	Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma. Atwa SM, Handoussa H, Hosny KM, Odenthal M, Tayebi HME.World J Hepatol. 2020 Dec 27;12(12):1211-1227. doi: 10.4254/wjh.v12.i12.1211.PMID: 33442449
Conference 2020	Virtual Screening and biological evaluation of potential PD-1/PD-L1 immune checkpoint inhibitors as anti-hepatocellular carcinoma agents. American Association for the Study of Liver Diseases, AASLD Congress November 2020. Monica A. Kamal , Yasmine M. Mandour , Hedy A. Badry , Dalia Omran , Hend I. Shoushaa, Ashraf O. Abdelaziz, and Hend M. El Tayebi
Conference 2020	Tackling TGF-β mediated Doxorubicin Chemoresistance by AZD5069 in Triple Negative Breast Mammospheres. ESMO Congress, September 2020 (Virtual) Alaa Ghallab , Reda A. Eissa and Hend M. El Tayebi
Conference 2020	Abrogation of Taxol® Chemo-resistance via Epigenetic Immune Checkpoints Regulation in Triple Negative Breast Cancer. ESMO Breast Cancer May 2020, Berlin. S. El Shihy, M. Armanious, R. Abdeltawab and H. M. El Tayebi
Conference 2020	MALAT-1 ruling the miR-182/PIG-C/MSLN triad in triple negative breast cancer ESMO Breast Cancer May 2020, Berlin. A. Samir, F. Barsoum, R. Abdeltawab and H. M. El Tayebi
Book Chapter 2020	Book Chapter titled: From whole blood to isolated pro-metastasis immune cells: an exvivo approach to isolate and manipulate immune cells contributing to tumor metastasis. Book name: Nature Protocols. Accepted March 2020 (in Online Publication process)

2019

Journal 2019	Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma. Waly AA, El-Ekiaby N, Assal RA, Abdelrahman MM, Hosny KA, El Tayebi HM, Esmat G, Breuhahn K, Abdelaziz AI. Front Physiol. 2019 Jan 24;9:1918. doi: 10.3389/fphys.2018.01918. eCollection 2018. PMID: 30733684 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353855/
Conference 2019	NEAT-1: culprit LncRNA tying PIG-C, MSLN, CD80 in TNBC.ESMO congress 2019, Barcelona N.H. Hussein, H.M. El Tayebi, M. de Bruyn, Annals of Oncology (2019)30(suppl_5): v760-v796. 10.1093/annonc/mdz268.
Conference 2019	Pivotal role of XIST in regulating immune checkpoint PD-1/PD-L1 through a shared pathway between miR-194-5p and miR-155-5p in Hepatocellular carcinoma. EASL HCC Summit 2019, Lisbon. S. Atwa, K. Hosny,, H. Handoussa and H. M. El Tayebi

Conference 2019	NEAT-1: culprit LncRNA tying PIG-C, MSLN, CD80 in TNBC.ESMO congress 2019, Barcelona N.H. Hussein, H.M. El Tayebi, M. de Bruyn, Annals of Oncology (2019)30(suppl_5): v760-v796. 10.1093/annonc/mdz268.
Conference 2019	Pivotal role of XIST in regulating immune checkpoint PD-1/PD-L1 through a shared pathway between miR-194-5p and miR-155-5p in Hepatocellular carcinoma. EASL HCC Summit 2019, Lisbon. S. Atwa, K. Hosny,, H. Handoussa and H. M. El Tayebi

2018

Journal 2018	Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis.El Khodiry A, Afify M, El Tayebi HM.World J Gastroenterol. 2018 Feb 7;24(5):549-572. doi: 10.3748/wjg.v24.i5.549. Review.PMID:29434445
Conference 2018	Paradoxically functioning onco-miR-155 and the tumor suppressor miR-194 consensus on PD-L1 immune checkpoint upregulation via MALAT1 and XIST in hepatocellular Carcinoma. April 2018, Journal of Hepatology, The International Liver Congress, EASL 2018.S. Atwa, K. Hosny,, H. Handoussa and H. M. El Tayebi
Book Chapter 2018	“Non-Coding RNAs as Future Cancer Biomarkers” Salama E.A. and El Tayebi H.M. Book name: Cancer Therapy Publisher: MedDocs International
Book Chapter 2018	"The Era of Immunotherapy in Breast Cancer” Samir, A. and El Tayebi H.M. Book name: Cancer Therapy Publisher: MedDocs International
Conference 2018	PIG-C and SOCS3; potential immunotargets regulated by non-coding RNAs in TNBC Dec 2018, ESMO Immuno-Oncology Congress. Monia Mohsen, Reda Abdeltawab and Hend M. El Tayebi

2017

Journal 2017	Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. Shaalan YM, Handoussa H, Youness RA, Assal RA, El-Khatib AH, Linscheid MW, El Tayebi HM, Abdelaziz AI. Nat Prod Res. 2017 Aug 18:1-4. doi: 10.1080/14786419.2017.1366478. [Epub ahead of print]PMID:28817968
Journal 2017	MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients.Rahmoon MA, Youness RA, Gomaa AI, Hamza MT, Waked I, El Tayebi HM, Abdelaziz AI. Growth Factors. 2017 Jun;35(2-3):76-87. doi: 10.1080/08977194.2017.1354859. Epub 2017 Jul27.PMID:28747084
Conference 2017	43PXIST and TSIX: Novel cancer-immune biomarkers showing differential expression in tumor, PBMCs, serum, nipple discharge and lymph nodes of PD-L1 overexpressing BC patients. Dec 2017, Annals of Oncology, E Atef R Abdel Tawab Hend M. El Tayebi
Conference 2017	42PDifferential expression of PD-L1, MALAT1 and XIST in tumors and lymph nodes of TNBC and IDC patients and their regulation by miR-182. Dec 2017, Annals of Oncology, A Samir R Abdel Tawab, Hend M. El Tayebi
Conference 2017	Regulation of PD-L1 immune check point by onco-miR-155 via LncRNA-MALAT-1 expression manipulation in hepatocellular carcinoma.Nov. 2017, EMBL. S. Atwa, K. Hosny,, H. Handoussa and H. M. El Tayebi
Conference 2017	Long non-coding RNAs, MALAT-1 and XIST: novel immune check point regulators manipulating PDL-1 expression under the control of mir-182 in breast cancer. Nov. 2017, EMBL, A. Samir R Abdel Tawab, Hend M. El Tayebi

2016

Journal 2016	miR-34a: Multiple Opposing Targets and One Destiny in Hepatocellular Carcinoma.Yacoub RA, Fawzy IO, Assal RA, Hosny KA, Zekri AN, Esmat G, El Tayebi HM, Abdelaziz AI. J Clin Transl Hepatol. 2016 Dec 28;4(4):300-305. doi: 10.14218/JCTH .2016.00031. Epub 2016 Dec 27.PMID:28097098
Journal 2016	MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc. Youness RA, El-Tayebi HM, Assal RA, Hosny K, Esmat G, Abdelaziz AI. Oncol Lett. 2016 Oct;12(4):2567-2573. Epub 2016 Jul 27.PMID:27698829
Journal 2016	Interplay between microRNA-17-5p, insulin-like growth factor-II through binding protein-3 in hepatocellular carcinoma.Habashy DA, El Tayebi HM, Fawzy IO, Hosny KA, Esmat G, Abdelaziz AI. World J Hepatol. 2016 Aug 18;8(23):976-84. doi: 10.4254/wjh.v8.i23.976.PMID:27621763
Journal 2016	Contradicting interplay between insulin-like growth factor-1 and miR-486-5p in primary NK cells and hepatoma cell lines with a contemporary inhibitory impact on HCC tumor progression.Youness RA, Rahmoon MA, Assal RA, Gomaa AI, Hamza MT, Waked I, El Tayebi HM, Abdelaziz AI.Growth Factors. 2016 Aug;34(3-4):128-40. doi: 10.1080/08977194. 2016.1200571. Epub 2016 Jul 8.
Review 2016	Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma. El Tayebi H M, Abdelaziz A I, World Jorunal of Gastroenetrology, March 2016 (ahead of print)
Conference 2016	29PXIST overrides the regulatory effect of miR-194 on its immunomodulatory target PD-L1 in breast cancer. Nov 2016, Annals of Oncology, Marwa Hamed R.A.E. Eissa Lobna Kassem Hend M. El Tayebi
Conference 2016	Restoring The Expression of Endogenous IGF-1 by miR-486 in NK Cells of HCC Patients Augments Its Cytotolytic Activity Against Hepatoma Cell Lines Apr 2016, Journal of Hepatology– EASL International Liver Congress, Barcelona, Spain. Rana A. Youness, Mai A. Rahmoon, Asmaa Gomaa, Imam Waked, Hend M El Tayebi., Ahmed I. Abdelaziz
Conference 2016	miR-155: A Double Faced microRNA With Respect to its impact on Tumorigenesis in Both Natural Killer Cells and Their Target Hepatocytes Apr 2016, Journal of Hepatology– EASL International Liver Congress, At Barcelona, Spain. Mai A. Rahmoon,Rana A. Youness, Asmaa Gomaa, Imam Waked, Hend M. El Tayebi, Ahmed I. Abdelaziz,

2015

Journal 2015	miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma.Fawzy IO, Hamza MT, Hosny KA, Esmat G, El Tayebi HM, Abdelaziz AI. FEBS Lett. 2015 Aug 4;589(17):2257-65.
Conference 2015	Modulating the Expression of the Activating Receptor NKG2D and the Inhibitory Receptor NKG2A of NK cells by miR-182 in HCC. Mohamed M. Abdelrahman*, Injy O. Fawzy, Asmaa I. Gomaa, Imam Waked, Gamal Esmat, Hend M. El Tayebi, Ahmed I. Abdelaziz..5th Clinical Epigenetics International Meeting March 5th - 6th, 2015, Düsseldorf, Germany
Conference 2015	IMPROVING NATURAL KILLER CELLS CYTOTOXICTY AND HARNESSING HEPATOCYTE CANCER PROGRESSION BY MIR-486-5P. Aya A. Bassiouni* , Mai A. Rahmoon1, Rana A. Youness, Asmaa I. Gomaa, Imam Waked, Gamal Esmat3, Hend M. El Tayebi, Ahmed I. Abdelaziz. European Associaton for the study of Liver, Vienna, EASL 2015 (Poster Presentation).
Book 2015	"miR-486-5p and Liver Cancer Therapy: A Beautiful Mind Act” Rana Ahmed youness. Hend M. El Tayebi • Asmaa I. Gomaa • Imam Waked • Gamal Esmat • Ahmed Ihab AbdelAziz Published by: Lambert Academic Publishing (LAP)
Book 2015	“miR-615 and miR-155: microRNAs governing HCC in a paradoxical manner” Hend M. El Tayebi , PhD and Ahmed I. Abdelaziz, MD,PhD.

2014

Journal 2014	Transcriptional activation of IGF-II/IGF-1R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular carcinoma. El Tayebi H.M., Waly A.A., Assal R.A., Hosny K.A., Esmat G. and Abdelaziz A.I., Oncology Letters, (November 2014)
Journal 2014	A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5p & miR-182-5p on IGF-1R, IGFBP-3 and IGF-II in Hepatocellular carcinoma. R. A.Assal , H. M.El Tayebi , K. A. Hosny , G.Esmat , A. I. Abdelaziz, Molecular Medicine Reports (June 2014)
Journal 2014	miR-155 induces mTOR expression via activation of IGF-II/IGF-1R axis and inhibitionof IGFBP-3 in Hepatocellular Carcinoma.. Hend M. El Tayebi; Amr A. Waly; Rana A. Youness; Mai A. Rahmon; Aya A. Bassiouni; Reem A. Assal; Karim A. Hosny; Gamal Esmat; Ahmed I. Abdelaziz.. American Association for Cancer Research (AACR), Philadelphia, USA. September 2014 (Poster Presentation)
Conference 2014	A coach, a playmaker, a defender and strikers: an epigenetic-target interplay in HCV/HCC.M.M. Fouad, N.M. Elemam, H.B. Sherif, S.A. El Sobky, R.A. Yacoub, A.K. Abelhamid, T. Elbaz, M.A. Mohey El Din , I.O. Fawzy , H.M. El Tayebi ,N. El-Ekiaby, R.Y. Mekky, G. Esmat ,A.I. Abdelaziz.European Associaton for the study of Liver, London, EASL 2014 (Poster Presentation).
Conference 2014	Unshielding IGF-II mRNA by targeting IGF2BPs through demethylating the Let-7a-3 gene in HCC cell lines. Waly A.A. ,El Tayebi H.M., Hosny K.A., Esmat G. and Abdelaziz A.I.HCC Summit, EASL, Geneva 2014

2013

Journal 2013	A Missing Correlation between the Number and Type of MEFV Mutations and Severity of Clinical Manifestations in Egyptian Pediatric FMF Patients. Injie O. Fawzy, Hend M. El. Tayebi, Menna M. El. Wassal, Farah H. El. Bibany, Samia Salah, Ahmed I. Abdelaziz , British Journal of Medicine and Medical Research, 2013.
Journal 2013	Detection of Y chromosome microdeletions in recurrent abortions among Egyptian females using SYBR Green Real Time PCR. Said M.M, Fahmi A.A, Hemeda H.M, Aly B, AbdelAal R.H, Nasr S.M, El Gamal M, Fawzy I.O, El Tayebi H.M, Abdelaziz A.I , Journal of American Science , 2013.
Journal 2013	Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic Hepatocellular Carcinoma and enhancement of cell growth upon reversing this expression pattern. H M El Tayebi, K Omar, S Hegy, M El Maghrabi, M El Brolosy, K A Hosny, G Esmat, A I Abdelaziz , Biochemical and Biophysical Research Communications, 2013.
Conference 2013	Failure of induction of the oncomiRic cluster miR-182/miR-96 in HCV-induced non-metastatic hepatocellular carcinoma tissues renders them as markers for metastasis.Asal R.A., El Tayebi H.M., Hosny K.A., Esmat G. and Abdelaziz A.I. European Society of Pathology, Lisbon 2013 (Oral presentation)
Conference 2013	MicroRNA-17-5p promotes tumorgenesis through the repression of IGFBP-3 and enhancement of Insulin-like growth factor signaling. Habashy D.A., El Tayebi H.M., Hosny K.A., Esmat G. and Abdelaziz A.I.European Society of Pathology, Lisbon 2013 (Poster presentation)
Conference 2013	Hypermethylation of MicroRNA let-7a-3 Gene Represses the Primary and Mature let-7a-3 with an Inverse Corelation to IGF-II mRNA in HCV-induced Hepatocellular Carcinoma. Waly A., El Tayebi H.M., Hosny K.A., Esmat G. , and Abdelaziz A.I.. European Associaton for the study of Liver, Amesterdam, EASL 2013 (Poster Presentation
Book 2013	“miR-615-5p and miR-155-5p in Hepatocellular Carcinoma Immunotherapy” Mai Atef, Rana Ahmed youness, Hend M. El Tayebi, Asmaa I. Gomaa, Imam Waked, Gamal Esmat, Ahmed Ihab AbdelAziz Published by: Lambert Academic Publishing (LAP)

2012

Journal 2012	miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. H M El Tayebi, K A Hosny, G Esmat, K Breuhahn, Ahmed Ihab Abdelaziz , FEBS letters , 2012.
Conference 2012	E2f-1 Transcript Knock Down via oncomiR-17-5p gain of function in Hepatocellular Carcinoma Cell Lines. El Tayebi H.M., Omar K., Hosny K.A., Esmat G. and Abdelaziz A.I.Humboldt Kolleg “Pharmaceutical and Biotechnological Therapies” September 2012 (Poster presentation)
Conference 2012	MiR-155 is an inducer for the insulin-like growth factor II mitogenic signaling pathway in HCV-progressed hepatocellular carcinoma.H.M. El Tayebi, K.A. Hosny, G. Esmat, K. Breuhahn, A.I. Abdelaziz.,European Associaton for the study of Liver, Barcelona, EASL 2012 (Poster Presenation).

2011

Journal 2011

Expression of Insulin-like Growth Factor-II, Matrix Metalloproteinases and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients. El Tayebi H, Salah W, El Sayed I, Zekri AR , Zayed N, Salem S, Esmat G and Abdelaziz AI : , Biomarkers, 2011.

2010

Conference 2010

Positive correlation between the up-regulated Matrix Metalloproteinases and their down-regulated tissue inhibitors with the clinical staging of Hepatocellular Carcinoma Patients. El Tayebi H.M, Salah W., Elsayed I.H., Zekri A., Esmat G. and Abdelaziz A.I. , ICMCO, 2010.

2009

Conference 2009

Dysregulation of the Overexpressed Insulin like growth Factor II (IGFII) by Tissue inhibitor of Metalloproteinases (TIMP1) in the peripheral blood of Patients with Hepatocellular Carcinoma. Eltayebi H, Zekri Abdelrahman and Abdelaziz AI : , 5th APASL Single topic conference, 2009.

Dr. Ragwa Mansour

Email: ragwa.mansour@guc.edu.eg
Office:B5-120
Ext: 3422

Biography

Ragwa Mansour Abdelghany; is a PhD holder of Pharmacology & Toxicology, faculty of Pharmacy & Biotechnology, at the GUC. She earned her Bachelor in Pharmaceutical sciences from Misr International University June 2002 then MSc in Pharmacology and Toxicology; October 2009; Faculty of Pharmacy and Biotechnology, GUC grade A+. On April 2014, she got her PhD in Pharmacology and Toxicology, GUC, Faculty of Pharmacy and Biotechnology, Grade A+. Her current post doc studies is in the field of neuro-pharmacology; specifically neurodegenerative diseases like Alzheimer’s disease. She is the Head of Advising Committee for the faculty of Pharmacy & Biotechnology, GUC.

Research Interests

Conducting multidisciplinary experimental trials to shed the light on the exact underlying mechanisms for the prevention & protection from neuro-degenerative diseases like Alzheimer's disease, Parkinson's & depression.
Finding novel therapeutic approaches like multi-functional natural compounds for the prevention & protection from neuro-degenerative diseases like Alzheimer's disease.

Publications

2024

Journal 2024

Hanaa B. Atya, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Sara Nageeb El Helaly, Heba Taha “Autophagy and exosomes; inter connected maestros in Alzheimer’s Disease” Inflammopharmacology; DOI: 10.1007/s10787-024-01466-3, April 2024

2018

Journal 2018	Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed “Neuromodulatory effect of Thymoquinone in attenuating glutamate-mediated neurotoxicity targeting the amyloidogenic and apoptotic pathways” Frontiers in Neurology, section Neurotrauma April 2018.
Conference 2018	Maged Alawa, Nadia M. Sharaf, Ragwa M. Abdelghany “Herbal medicine use in alleviating cognitive dysfunction” for poster presentation in biochemistry & molecular biology in the 21st century bridges to translational medicine pharmaceutical technology conference, March 2018, GUC

2014

Journal 2014	Ragwa M. Abdelghany, Nadia M. Sharaf, Nesrine S. El Dine , Laila G. Mahran, "Interplay between LPS induced oxidative stress and Amyloid beta deposition in Alzheimer’s disease and treatment with Glycyrrhizin"; Journal of Experimental and Applied Animal Sciences, 2014; 1(2): 212-228.
Conference 2014	Ragwa M. Abdelghany, Nadia M. Sharaf, Nesrine S. El Dine, Laila G. Mahran, “Role of Glycyrrhizin in the modulation of neurotransmitters and memory alteration in Alzheimer’s disease” for oral presentation in the 10th International Congress of the European Union Geriatric Medicine Society De Doelen, Rotterdam, the Netherlands, September, 17-19, 2014.
Conference 2014	Nadia M. Sharaf, Ragwa M. Abdelghany, Nesrine S. El Dine, Laila G. Mahran, "Neuroprotective effect of thymoquinone against lipopolysaccharide induced Alzheimer in an animal model” for poster presentation in the 10th International Congress of the European Union Geriatric Medicine Society De Doelen, Rotterdam, The Netherlands, September 17-19, 2014

2009

Journal 2009

Ragwa M. Abdelghany, Nadia M. Sharaf, Lobna A. Kassem, Laila G. Mahran, Ola A. Heikal, “Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury’’ Drug Discoveries and Therapeutics, 2009; 3(6):296-306.

Dr. Nadia Mohamed Sharaf

Email: nadia.sharaf@guc.edu.eg
Office:B5-120
Ext: 3422

Biography

Nadia Mohamed Sharaf is a PhD holder of Pharmacology and Toxicology at the faculty of Pharmacy and Biotechnology, German University of Cairo. She has been working in the field of teaching since she was graduated from a reputable university in Egypt Misr international university in 2002. She earned her PhD in 2014 with an excellent grade under the title of Neuroprotective effect of Thymoquinone against Lipopolysaccharide induced Alzheimer in an Animal Model. Since that time, she has been working in the field of neurology with different research activities including publications in reputable journals, supervising master and PhD students in addition to participation in different workshops.
Her work at the GUC enriched both her academic and administrative knowledge and experience.
On the academic level working in a community like the GUC with its mixed culture Egyptian and German professors with no doubt let her to be exposed to the international standard and up to date techniques used in the teaching process; which has its impact on the academic level of the students.
On the administrative level she has been working as the head of the advising committee since 2016. Working in such a position deepened her understanding and acceptance to others to a great extent; in addition to understanding more and more the psychology of the students. This bond and interaction with the students are reflected on her academic performance to a great extent.
Moreover, she has been working in different faculty committees including: scheduling, internship and industrial link and Quality management& accreditation

Research Interests

Conducted research in the field of neurodegenerative diseases
Conducted research in the field of liver diseases
Conducting research in the field of regenerative medicine

Publications

2024

Journal 2024

2018

Journal 2018	Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed “Neuromodulatory effect of Thymoquinone in attenuating glutamate-mediated neurotoxicity targeting the amyloidogenic and apoptotic pathways” Frontiers in Neurology, section Neurotrauma April 2018.
Conference 2018	Maged Alawa, Nadia M. Sharaf, Ragwa M. Abdelghany “Herbal medicine use in alleviating cognitive dysfunction” accepted for poster presentation in biochemistry & molecular biology in the 21st century bridges to translational medicine pharmaceutical technology conference, March 2018, GUC.
Conference 2018	Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed, “Neuroprotective effect of Thymoquinone against glutamate-induced neurotoxicity targeting the amyloidogenic and apoptotic pathways, poster presentation in Biochemistry & Molecular biology in the 21st century bridges to translational medicine pharmaceutical technology conference, March 2018, GUC.

2015

Conference 2015

Nadia M. Sharaf, Ragwa M. Abd El-Ghany, Nesrine Salah El-Dine, Laila G. Mahran “Neuroprotective effect of thymoquinone against lipopolysaccharide-induced behavioral and neurotransmitter alteration in an animal model “was accepted for presentation in the 12th international conference of Alzheimer’s and Parkinson’s Diseases and related neurological disorder (AD/PDTm 2015) Nice, France, March18-22, 2015

Conference 2015

Nadia M. Sharaf, Ragwa M. Abd El-Ghany, Nesrine Salah ElDine, Laila G. Mahran “Glycyrrhizin attenuates oxidative stress and neuroinflammation: Novel approach targeting Alzheimer’s disease” was accepted for presentation in the 12th international conference of Alzheimer’s and Parkinson’s Diseases and related neurological disorder (AD/PDTm 2015) Nice, France, March18-22, 2015.

2014

Journal 2014	Ragwa M. Abdelghany, Nadia M. Sharaf, Nesrine S. El Dine , Laila G. Mahran, "Interplay between LPS induced oxidative stress and Amyloid beta deposition in Alzheimer’s disease and treatment with Glycyrrhizin"; Journal of Experimental and Applied Animal Sciences, 2014; 1(2): 212-228.
Conference 2014	Nadia M. Sharaf, Ragwa M. Abd El-Ghany, Nesrine Salah ElDine, Laila G. Mahran “Neuroprotective effect of thymoquinone against lipopolysaccharide induced Alzheimer in an animal model” was accepted for presentation in the 10th International Congress of the European Union Geriatric Medicine Society De Doelen, Rotterdam, The Netherlands, and September 17-19, 2014.
Conference 2014	Ragwa M. Abd El-Ghany, Nadia M. Sharaf, Nesrine Salah ElDine, Laila G. Mahran “Role of Glycyrrhizin in the modulation of neurotransmitters and memory alteration in Alzheimer’s disease” was accepted for presentation in the 10th International Congress of the European Union Geriatric Medicine Society De Doelen, Rotterdam, The Netherlands, September, 17-19, 2014.

2009

Journal 2009

Dr. Mervat I. Khairallah

Email: mervat.khairallah@guc.edu.eg
Office:B5-125
Ext: 3403

Biography

Mervat Ibrahim Khairallah is a member of Physiology department (Pharmacology and Toxicology), she joined the GUC in 2005. Mervat completed her medical undergraduate degree from the Faculty of Medicine, Cairo University, and obtained her master’s degree from the Faculty of Medicine, Ein Shams University. She also received a Diploma in Total Quality Management (TQM) in Health Care from the American University in Cairo (AUC) in 2003.
Mervat also received her PhD in Molecular Physiology from the Faculty of Pharmacy and Biotechnology at the German University in Cairo in 2012. She has extensive teaching experience having conducted lectures, tutorials and practical classes in Physiology. In addition, she is the course lecturer and coordinator of Pharmaceutical and Medical Terminology for the last five successive years.
Mervat has supervised many Master and PhD thesis. In addition she has organized several workshops in the GUC and attended many conferences in Egypt and abroad.

Research Interests

Her research interest is focused in the field of neuroscience, mainly in neuro-inflammatory disorders of the CNS and neurodegenerative diseases, and to find new therapeutic approaches for prevention and protection from neuro-degenerative diseases.
On the administrative level, she is a member of mentoring program of Pharmacy faculty; she is a member of experimental ethics committee and participates in the scheduling of advising students. In addition, she is responsible for the control of the 7th and 8th semester exams.

Publications

2016

Journal 2016	“Effect of SERCA gene modified stem cells on functional recovery of diabetic cardiomyopathy” L A Kassem1, 2, Y Safwat1, N A Yassin1, 2, M A Gamal El Din1, 2, M S Fadel3, M B Zekri2, S G Abo Elfadl2 and M I Khairallah1. 5th International Conference on Tissue Engineering & Regenerative Medicine, conferenceseries.com September 12-14, 2016 Berlin, Germany, J Tissue Sci Eng 2016, 7:2(Suppl).
Journal 2016	“Activation of migration of endogenous stemcells by erythropoietin as potential rescue for neurodegenerative diseases”. Khairallah MI1, Kassem LA2, Yassin NA2, El Din MA2, Zekri M3, Attia M3. Brain Res Bull. 2016 Mar; 121:148-57.

2014

Journal 2014

“The hematopoietic growth factor "erythropoietin" enhances the therapeutic effect of mesenchymal stem cells in Alzheimer's disease”. Khairallah MI, Kassem LA, Yassin NA, El Din MA, Zekri M, Attia M.
Pak J Biol Sci. 2014 Jan 1;17(1):9-21.

2011

Journal 2011	“Alzheimer's disease: current status of etiopathogenesis and therapeutic strategies”. (2011) Khairallah MI1, Kassem LA. Pak J Biol Sci. 2011 Feb 15;14(4):257-72.
Journal 2011	“Alzheimer's disease: current status of etiopathogenesis and therapeutic strategies.”Khairallah MI1, Kassem LA. Pak J Biol Sci. 2011 Feb 15;14(4):257-72.

1998

Journal 1998

“Reapraisal of autonomic function tests in young Saudi subjects” Kabiraj MMU, Shaikh, Zahoor A, Khairallah M, 1998-, Journal of neuroscience, Vol 3 No 3, 1998

Dr. Aya Zakaria

Email: aya.Zakaria@guc.edu.eg
Office:B1-115

Biography

Aya is an Assistant Lecturer of Pharmacology and Toxicology in the faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Egypt.
She was awarded her bachelor’s degree with high honors from the faculty of Pharmacy and Biotechnology, GUC, in 2011. In the same year, she was appointed as a teaching assistant at the GUC. Aya Zakaria obtained her M.Sc. and PhD degrees in the field of Pharmacology and Toxicology in the period from 2011-2016.
She has been teaching various theoretical and practical courses in the Pharmacology and Toxicology department. In addition to teaching and research, she is also a member of the advising and internship committees, as well as the strategic planning committee.

Research Interests

Research interest focuses on interactions between the brain and the immune system which was shown to play important roles in neurodegenerative diseases, with the focus on underlie aberrant gene expression and epigenetic dysregulation, on disease pathogenesis and progression and understanding endogenous neuroprotection. Understanding these interactions with functional and behavioral approaches to in vitro and mouse models of disease develop a better understanding of, and novel therapeutic strategies for, a range of different disorders to tackle neurodegenerative disorders like Alzheimer's and Parkinson's disease.

Publications

2019

Journal 2019

Zakaria Aya, Rady Mona, Mahran Laila, Abou-Aisha Khaled. Year (2019) “Pioglitazone Attenuates Lipopolysaccharide-Induced Oxidative Stress, Dopaminergic Neuronal Loss and Neurobehavioral Impairment by Activating Nrf2/ARE/HO-1” Journal Neurochem Res 44, 2856–2868. IF 3.038

2018

Journal 2018	A. Shoukry, A. Zakaria, N. El Sayed.AKBA, a terpenoid from Boswellia serrata modulates Nrf2/HO-1 signaling pathway in a mouse model of neurodegeneration. European Journal of Neurology. 2018;25(suppl2). https://doi.org/10.1111/ene.13696
Journal 2018	Zakaria A, Shoukry A, Abu-Aisha K. Pioglitazone neuroprotective effect through the link between Nrf2/HO-1 signaling pathway and miR-155 in a Mouse model of systematic inflammation. European Journal of Neurology. 2018;25(suppl2). https://doi.org/10.1111/ene.13696

2016

Journal 2016

A Zakaria, N Hamdi, RM Abdel-Kader. Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model. Molecular Neurobiology 2016 Mar;53(2):1220-8. doi: 10.1007/s12035-014-9088-8

2015

Journal 2015

Zakaria A, Shoukry A, Abu-Aisha K. A single intraperitoneal lipopolysaccharide injection successfully induced Parkinson's disease in mice. European Journal of Neurology.2015;22(suppl1). https://doi.org/10.1111/ene.12808

2013

Journal 2013

Abdel-Kader RM, Zakaria A, Hamdi N. Methylene blue decreases brain mitochondrial ABAD and amyloid beta levels protecting mitochondrial functions in LPS-mouse model. Mol Neurodegener. 2013;8(Suppl 1):P1. Published 2013 Sep 13. doi:10.1186/1750-1326-8-S1-P1

Dr. Mirna Ezzat Sedrak Sorial

Email: mirna.sorial@guc.edu.eg

Email: lobna.masoud@guc.edu.eg

Office: B7.207

Email: alaa.ameen-selim@guc.edu.eg Office: B1.225
read more

Biography

Alaa is currently a PhD holder in the department of Pharmacology and Toxicology. Alaa graduated from the faculty of Pharmacy and Biotechnology, German University in Cairo in 2014 with highest honors. She was appointed as a teaching assistant and got her master’s degree with excellence in 2016. In 2016, she was appointed as an assistant lecturer and started her PhD. She conducted her PhD project in collaboration with the department of Neurology, Ulm University. She got her PhD with excellence in 2021. She has taught several theoretical and practical courses: Pharmacognosy, Phytochemistry, Clinical Pharmacy, Toxicology, and Pharmacoepidemiology and Economy. Moreover, she is a course instructor in the master's course of Pharmacology and Toxicology for postgraduate students. She is also a member of several committees including advising, mentoring and internship committees.

Research Interests

The main research interest is the evaluation of exosomes/extracellular vesicles as a novel tool in biomarker discovery and treatment. The focus is on the evaluation of their isolation techniques and their possible application in biomarker discovery in several diseases including neurodegenerative diseases. Other research interests include studies using mouse models for neurodegenerative disease and the effects of drugs and natural products on them.

Publications

2022

Poster 2022

"Combined immunoprecipitation and polymer-based precipitation for the isolation of serum-derived exosomes" Alaa Selim, MHD Rami Al Shweiki, Lobna Kassem, Nabila Hamdi, Markus Otto. Accepted as a poster at the 16th World Congress on Controversies in Neurology (CONy), March 24-27, 2022 (virtual)

2021

Poster 2022

"Evaluation of a combined polymer and size exclusion chromatography-based protocol for the isolation of serum-derived exosomes" Alaa Selim, MHD Rami Al Shweiki, Nabila Hamdi, Lobna Kassem, Markus Otto. Accepted as a poster at the 15th World Congress on Controversies in Neurology (CONy), September 23-26, 2021 (virtual)

2016

Poster 2016

"The in vivo triad behind the neuromodulatory effect of Bauhinia variegata L" Alaa Selim, Heba Handoussa, Nesrine El Sayed. Conference abstract at the 5th International Conference on Alzheimer’s Disease & Dementia, September 29-October 01, 2016, London, UK

Dr. Radwa Mohamed Sabry Saad

Email: Radwa.Saad@guc.edu.eg

Office: B5.228

Email: Monica.Mosaad@guc.edu.eg

Office: B6.208

Biography

Monica is an Assistant Lecturer and Podtdoc fellow in Pharmacology and Toxicology department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC).

Monica Mosaad earned her M.Sc. degree and PhD degrees in pharmacology and toxicology. She received her PhD degree with excellence from the GUC in 2023, afterwards she has been appointed as an Assistant Lecturer in the GUC. In the Pharmacology and Toxicology department, she has been instructing a variety of theoretical and practical courses. She is a member of the advising and mentoring committees in addition to teaching and conducting research..

Research Interests

• Chemokines modulation in various cancer cell lines and their role in cancer progression.

• Drug discovery, drug screening, cancer therapy

• Targeted genome editing in mammalian cells using CRISPR/Cas9 nucleases.

• Microarray and microarray analysis programs

Publications

2024

Journal 2024	Rawan Amr Elmasri, Alaa A. Rashwan, Sarah Hany Gaber, Monica Mosaad Rostom, Paraskevi Karousi, Montaser Bellah Yasser, Christos K. Kontos, Rana A. Youness, Puzzling out the role of MIAT LncRNA in hepatocellular carcinoma, Non-coding RNA Research, Volume 9, Issue 2, 2024, Pages 547-559, ISSN 2468-0540 https://www.sciencedirect.com/science/article/pii/S2468054024000064
Journal 2024	A. Dawoud, R.A. Elmasri, A.H. Mohamed, A. Mahmoud, M.M. Rostom, R.A. Youness, Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma, Critical Reviews in Oncology/Hematology, Volume 196, 2024, 104312, ISSN 1040-8428 https://www.sciencedirect.com/science/article/pii/S1040842824000556?via%3Dihub

2019

Conference 2019

EACR conference - Barcelona, Spain (2019) Master Abstract Publication: “Disruption of the chemokine receptor gene CCR5 results in massive apoptotic cell death in the murine colorectal cell line CC531” Monica Mosaad Rostom, Reem Amr Assal, Manar Soliman, Khaled Abou Aisha, Hassan Adwani.

Dr. Noha Fouad ElHadary

Email: Noha.Elhadary@guc.edu.eg

Office: B5.127

Deanship

Departments

Biochemistry

Clinical Pharmacy

Microbiology, Immunology and Biotechnology

Pharmaceutical Biology

Pharmaceutical Chemistry

Pharmacology and Toxicology

Pharmaceutical Technology

Academic Coordinators

Academic Committees

Ethics Committee

Teaching Assistants Support Committee

Academic Curriculum Committee

Academic Training Committee

Admission - Apply Now Online

GUC Berlin

Webmail

Student Portal

Accredited By:

Pharmacology and Toxicology

Head of Pharmacology and Toxicology Department Assoc. Prof. Reham Abdel-Kader

Biography

Research Interests

Publications

2019

2018

2016

2014

2013

2012

2010

2009

2007

2006

2005

Prof. Lobna Abdelaal Kassem

Biography

Research Interests

Publications

2016

2014

2013

2011

2010

2009

2008

2004

2001

Prof. Nabila Hamdi

Biography

Research Interests

Publications

2023

2022

2021

2019

2018

2017

2016

2015

2014

2013

2012

2011

2009

Assoc. Prof. Hend El Tayebi

Biography

Research Interests

Publications

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

Dr. Ragwa Mansour

Biography

Research Interests

Publications

2024

2018

2014

2009

Dr. Nadia Mohamed Sharaf

Biography

Research Interests

Publications

2024

2018

2015

Head of Pharmacology and Toxicology Department
Assoc. Prof. Reham Abdel-Kader