Biography | Ashraf Abadi is Full Professor and Head of the Department of Pharmaceutical Chemistry at the German University in Cairo. He also served as the Dean of the faculty (2011-2016). In addition, he was a full professor in Pharmacy, Cairo University from 2006-2016. He studied Pharmacy in Cairo University and received his Master and Ph.D. in Pharmaceutical Chemistry from the Cairo University and the University of Florida, USA. He worked as a visiting professor in King Saud University, Saudi Arabia, and Universities of Bonn, Erlangen, Jena and Saarland, Ulm and Tubingen, in Germany. He is an Alexander von Humboldt (AvH) fellow as well as DAAD fellow since 1999 and served as Ambassador Scientist of the Alexander von Humboldt foundation in Egypt (2010-2015). He has a track record of >90 publications in impact international journals, 7 international patents and patents applications, and served as a referee and editorial board member for many International organizations and Scientific journals. He supervised more than seventy Master and Doctoral theses. In addition he is a recipient of so many national and international awards and grants. He is a member of the American Chemical Society, the Egyptian Syndicate of Pharmacy and the Arab Pharmacists Union. His research interests are synthetic Medicinal Chemistry and Computer Aided Drug Design. | Research Interests | 1. Medicinal Chemistry 2. Computer Aided Drug Design 3. Pharmaceutical and Biomedical Analysis 4. Mechanisms of action of Pharmaceuticals |
Publications2020Journal 2020 | Mirja Harms, Monica MW Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B, 2020, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2020.12.005. | | Journal 2020 | Abdel-Halim M, Tinsley H, Keeton AB, Weam M, Atta NH, Hammam MA, Hefnawy A, Hartmann RW, Engel M, Piazza GA, Abadi AH. Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors. Bioorg Chem. 2020 Nov;104:104322. doi: 10.1016/j.bioorg.2020.104322. | | Journal 2020 | Abdel Karim SE, Youssef YH, Abdel-Halim M, Frakolaki E, Vassilaki N, Zoidis G, Ahmed NS, Abadi AH. Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates. Bioorg Chem. 2020 Sep;102:104089. doi: 10.1016/j.bioorg.2020.104089. | | Journal 2020 | Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M. Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents. Bioorg Chem. 2020 Jun;99:103759. doi: 10.1016/j.bioorg.2020.103759. | | Journal 2020 | ElHady AK, Shih SP, Chen YC, Liu YC, Ahmed NS, Keeton AB, Piazza GA, Engel M, Abadi AH, Abdel-Halim M. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742. doi: 10.1016/j.bioorg.2020.103742. |
2019| Journal 2019 | Wadea NE, Issac MM, Osman NA, Abadi AH. Benzofuran and pyrrole derivatives as cannabinoid receptor modulators with in vivo efficacy against ulcerative colitis. Future Med Chem. 2019 Dec;11(24):3139-3159. doi: 10.4155/fmc-2019-0172. | | Journal 2019 | Leila ARS, Mousa MHA, Frakolaki E, Vassilaki N, Bartenschlager R, Zoidis G, Abdel-Halim M, Abadi AH. Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds. ACS Omega. 2019 Jul 1;4(7):11440-11454. doi: 10.1021/acsomega.9b01242. | | Journal 2019 | Ghonim AE, Ligresti A, Rabbito A, Mahmoud AM, Di Marzo V, Osman NA, Abadi AH. Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties. Eur J Med Chem. 2019 Oct 15;180:154-170. doi: 10.1016/j.ejmech.2019.07.002. |
2018| Journal 2018 | Darwish SS, Abdel-Halim M, ElHady AK, Salah M, Abadi AH, Becker W, Engel M. Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification. Eur J Med Chem. 2018 Oct 5;158:270-285. doi: 10.1016/j.ejmech.2018.08.097. | | Journal 2018 | Darwish SS, Abdel-Halim M, Salah M, Abadi AH, Becker W, Engel M. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. Eur J Med Chem. 2018 Sep 5;157:1031-1050. doi: 10.1016/j.ejmech.2018.07.050 | | Journal 2018 | Abdel-Halim M, Abadi AH, Engel M. Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ). Medchemcomm. 2018 May 7;9(6):1076-1082. doi: 10.1039/c8md00100f. | | Journal 2018 | Ramsis TM, Abdel Karim SE, Vassilaki N, Frakolaki E, Kamal AAM, Zoidis G, Ahmed NS, Abadi AH. Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches. Arch Pharm (Weinheim). 2018 Jul;351(7):e1800017. doi: 10.1002/ardp.201800017. | | Journal 2018 | El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH. Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors. Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. |
2017| Journal 2017 | ElHady AK, Abdel-Halim M, Abadi AH, Engel M. Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. J Med Chem. 2017 Jul 13;60(13):5377-5391. doi: 10.1021/acs.jmedchem.6b01915. | | Journal 2017 | Hamed MM, Darwish SS, Herrmann J, Abadi AH, Engel M. First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents. J Med Chem. 2017 Apr 13;60(7):2853-2868. doi: 10.1021/acs.jmedchem.6b01774. |
2016Journal 2016 | Structure-based design of novel tetrahydro-beta-carboline derivatives with a hydrophilic side chain as potential phosphodiesterase inhibitors. Ahmed K. Elhady, Sara C. Sigler, Nazih Noureldin, Joshua C. Canzoneri, Nermin S. Ahmed, Gary A. Piazza, Ashraf H. Abadi, Sci Pharm, 2016. in press. doi:10.3797/scipharm.1507-16 | Journal 2016 | Design and Synthesis of Novel Flexible Ester-containing Analogues of Tamoxifen and Their Evaluation as Anticancer Agents. Nehal H. Elghazawy, Mathias Engel Rolf W. Hartmann, Mostafa M. Hamed, Nermin S. Ahmed, Ashraf H. Abadi, Future Medicinal Chemistry, 2016. 8(3), 249-56 (2016) | Journal 2016 | Synthesis and Optimization of New 3,6-disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. Mohamed SalahRezk, Mohammad Abdel-Halim, Adam Keeton, DerekFranklin, Matthias Bauer, Frank Michael Boeckler,Matthias Engel, Rolf Wolfgang Hartmann,Yanping Zhang, Gary Anthony Piazza, Ashraf HassanAbadi.Chemical and Pharmaceutical bulletin (Tokyo), 2016. 64(1), 34-41 (2016). | Journal 2016 | Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism
Ahmed NS, Elghazawy NH, ElHady AK, Engel M, Hartmann RW, Abadi AH, Eur J Med Chem. , 2016.112:171-9 (2016). | Conference 2016 | Personalized or Impersonalized: That is the Question. Ashraf H. Abadi. Faculty of Pharmacy, Cairo University, 7th International Scientific Conference, 2016.
Keynote speaker | Conference 2016 | Design and Synthesis of Novel Tamoxifen Analogues and tehir Evaluation as Sepective Estrogen Receptor Modulators, Ashraf. H. Abadi, Nermin S. Ahmed, Rasha M. Rashied, G?nter Vollmer, Jannette Wober, Faculty of Pharmacy, Cairo University, 7th International Scientific Conference. , 2016. poster presentation. Best Poster Award | Conference 2016 | Approaches to Computer-Aided Drug Design and Drug Re-positioning Ashraf. H. Abadi, Arab-African Pharma Conference, Cairo,Egypt 5-7 May 2016. , 2016. Keynote Speaker | Conference 2016 | Design and Synthesis of Novel Non CYP 2D6 mediated Tamoxifen Analogues.
Nehal H. Elghazawy, Nermin S. Ahmed, Bianca Liederer, Rolf Hartmann, Ashraf. H. Abadi.Pharmaceutics & Novel Drug Delivery Systems. March 07-09, 2016 Madrid, Spain., 2016. Poster presentation. best poster award | Conference 2016 | Clinical Pharmacy Session, Ashraf H. Abadi : Clinical Pharmacy Session , Breast Gynecological International Cancer Conference, Clinical Pharmacy, 2016.
Chairperson | | Journal 2016 | Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M. Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016. | | Journal 2016 | Osman NA, Ligresti A, Klein CD, Allarà M, Rabbito A, Di Marzo V, Abouzid KA, Abadi AH. Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality. Eur J Med Chem. 2016 Oct 21;122:619-634. doi: 10.1016/j.ejmech.2016.07.012. |
2015Conference 2015 | At the Cross line between Celecoxib and Sildenafil. Ashraf H. Abadi. : At the Cross line between Celecoxib and Sildenafil. ,3rd FUE-International Conference on Pharmaceutical Sciences., 2015.Cairo, Egypt. February 2015. | Conference 2015 | A novel celecoxib derivative that lacks COX-2 inhibition but displays potent colon tumor cell growth and PDE5 inhibitory activity Sara C. Sigler, Veronica Ramirez-Alcantara, Adam B. Keeton, Mohammad Abdel-Halim, Ashraf H. Abadi, Gary A. Piazza , American association for Cancer Research AACR annual meeting., 2015. Pennsylvania, USA. April 2015. | Conference 2015 | Internationalization of Science and Research in Egypt. Ashraf H. Abadi : Internationalization of Science and Research in Egypt , Europe and Mediterranean Regions: History, Emergencies, and Chances, 2015. Lecce, Italy. April 2015 | Patent 2015 | Allosteric Inhibitors of Atypical Protein Kinases C Matthias Engel, Mohammad Abdel-Halim and Ashraf H. Abadi : Allosteric Inhibitors of Atypical Protein Kinases C , - , 2015. PCT WO/2015/075051 | Journal 2015 | D1-like receptors distinguishing thieno-azecine regioisomers.Abdel-Fattah, Mohamed A. O.; Abadi, Ashraf H.; Lehmann, Jochen; Schweikert, Peter M.; Enzensperger, Christoph. : D1-like receptors distinguishing thieno-azecine regioisomers. , MedChemComm, 2015. 6, 1679-1686 (2015). | Journal 2015 | Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents. Habib MM, Abdelfattah MA, Abadi AH. Agents , Arch Pharm (Weinheim)., 2015. 348, 868-74 (2015) | Journal 2015 | Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. Hassaan EA, Sigler SC, Ibrahim TM, Lee KJ, Cichon LK, Gary BD, Canzoneri JC, Piazza GA, Abadi AH. : Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach , Med Chem, 2015. Dec 3. [Epub ahead of print] |
2014Conference 2014 | A novel series of celecoxib derivatives lacking COX-2 inhibitory activity more potently inhibits cancer cell growth by inhibiting PDE5. Sara C. Sigler, Veronica Ramirez, Ashraf Abadi, Gary Piazza : A novel series of celecoxib derivatives lacking COX-2 inhibitory activity more potently inhibits cancer cell growth by inhibiting PDE5. , American Association for Cancer Research (AACR), annual meeting, 2014. San Diego, USA. 5-9 April 2014 | Journal 2014 | 1,3,5-trisubstituted pyrazolines as potent and highly selective inhibitors of protein kinasce C-zeta. Mohammad Abdel-Halim, Britta diesel , Alexandra K. Kiemer, Ashraf H. Abadi, Rolf W. Hartmann, Matthias Engel : 1,3,5-trisubstituted pyrazolines as potent and highly selective inhibitors of protein kinasce C-zeta. , J. Med. Chem, 2014. 57, 6513-30 (2014). | | Journal 2014 | Design and Synthesis of Novel Quinazoline Derivatives and Their Evaluation as PI3Ks Inhibitors.Omar Maged El-Said, Mostafa Mohamed Hamed, Stefan Laufer, Ashraf Hassan Abadi. : Design and Synthesis of Novel Quinazoline Derivatives and Their Evaluation as PI3Ks Inhibitors , Chem Pharm. Bull. (Tokyo). , 2014.
2014;62(12):1166-72 | Journal 2014 | Naphtahlene and 2,3-dihydrobenzo[b][1,4]dioxin Derivatives With Extended Side Chains as New Scaffolds of CB2 Selective Ligands. Noha A. Osman, Amr H. Mahmoud, Christian D. Klein, Marco Allaràd, Vincenzo Di Marzod, Khaled M. Abouzid, Ashraf H. Abadi : Naphtahlene and 2,3-dihydrobenzo[b][1,4]dioxin Derivatives With Extended Side Chains as New Scaffolds of CB2 Selective Ligands. , MedChem Comm, 2014.5, 1571-157 (2014). | | Journal 2014 | An Efficient and Green One-Pot Synthesis of Novel Spirooxindole Derivatives with Potential Anti-tumor Activity in an Aqueous Solvent. abadi chem rapid comm 2014_2.pdf Lobna M. Elwarraky, Mohamed A. O. Abdel-Fattaha, Bernard D. Gary, Gary A. Piazzab, Ashraf H. Abadi : An Efficient and Green One-Pot Synthesis of Novel Spirooxindole Derivatives with Potential Anti-tumor Activity in an Aqueous Solvent. , Chem rapid Comm, 2014. 2, 33-40 (2014). | Journal 2014 | Spectrophotometric Determination of Imatinib Mesylate using Charge Transfer Complexs in Pure Form and Pharmaceutical Formulation
abadi chem rapid comm 2014.pdf Shereen. E. Abdel Karim, Raafat. A. Farghaly, Rasha. M. El-Nashar, Ashraf. H. Abadi : Spectrophotometric Determination of Imatinib Mesylate using Charge Transfer Complexs in Pure Form and Pharmaceutical Formulation , Chem Rapid Comm, 2014.2, 55-63 (2014) | | Journal 2014 | Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt. Rasha S. Hanafi, Mansour S. Mohamed, Mohamed Ashour, Mona Z. El-Readi, Said Y. Desouky, Raimnd R. Niess, Ashraf H. Abadi, Michael M. Wink : Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt , Nat. Prod. J. , 2014. 4, 63-69 (2014). | Conference 2014 | Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. Ashraf H. Abadi, Engi Engi A. Hassan, Gary A. Piazza : Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. , International Scientific Committee. Humboldt-Kolleg / International Conference of Theory and Computation in Sciences and Bio-Sciences. , 2014. Tlemcen, Algeria. November 2014 | Conference 2014 | Drug Discovery using Chemical Libraries.Ashraf H. Abadi. : Drug Discovery using Chemical Libraries. , Scientific Congress of teh Associations of Colleges of Pharmacy in the Arab World, 2014.
Cairo, Egypt. October 2014 | Workshop 2014 | Intellectual property and Antiviral Medications. Ashraf H. Abadi : Intellectual property and Antiviral Medications , Fraunhofer Workshop on Infection Biology and Aquaculture, 2014. DAAD, Cairo, Egypt September 2014. | Conference 2014 | Dual Inhibitors of Epidermal Growth factor receptor kinase and the NF-?B pathway as potential anti-cancer drugs with enhanced efficacy. Mostafa M. Hamed, Jennifer Hermann, Ashraf H. Abadi, Rolf W. Hartmann, Matthias Engel : Dual Inhibitors of Epidermal Growth factor receptor kinase and the NF-?B pathway as potential anti-cancer drugs with enhanced efficacy. , XXIII International Symposium on Medicinal Chemistry , 2014. Lisbon, Portugal September 2014 | Conference 2014 | A Novel Series of Celecoxib Derivatives that Inhibit PDE 5 but Lack COX-2 Inhibitory Activity Potently Inhibit Colon Cancer Cell Growth. Sara C. Sigler, Ashraf H. Abadi, and Gary A. Piazza : A Novel Series of Celecoxib Derivatives that Inhibit PDE 5 but Lack COX-2 Inhibitory Activity Potently Inhibit Colon Cancer Cell Growth. , Gordon research Conference, Cyclic Nucleotide Phosphodiesterases, Signaling Regulation in the Pathogenesis and Treatment of Disease, 2014.Massachussete, USA. 1-6 June 2014 |
2013Journal 2013 | Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes Azza T. Taher, Hanan H. Kadry, Marco Allarà, Vincenzo Di Marzo, Ashraf H. Abadi, Khaled A. Abouzid : Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes , J Enzy Inhibit Med Chem, 2013.
28, 436-439 | Journal 2013 | Functional evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells. Mai A. Saad Zaghloul, Ashraf H. Abadi, Ahmed I. Abdelaziz. : Functional evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells , Rec Patents Biomark, 2013.
3, 65-71 | Journal 2013 | Design of Novel ß-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors. Dalia S. El-Gamil, Nermin S. Ahmed, Bernard D. Gary, Gary A Piazza, Matthias Engel, Rolf W. Hartmann, Ashraf H. Abadi : Design of Novel ß-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors , Arch Pharm, 2013.
346, 23-33 | Journal 2013 | New NSAID targets and derivatives for colorectal cancer chemoprevention Heather N. Tinsley, William E. Grizzle, Ashraf Abadi, Adam Keeton, Bing Zhu, Yaguang Yen , Gary A. Piazza. : New NSAID targets and derivatives for colorectal cancer chemoprevention , Recent Results Cancer Res. , 2013.
191, 105-20 | Journal 2013 | Modulating the Cyclic Guanosine Monophosphate Substrate Selectivity of the Phosphodiesterase 3 Inhibitors by Pyridine, Pyrido[2,3-d]pyrimidine Derivatives and Their Effects upon the Growth of HT-29 Cancer Cell Line. Ashraf H. Abadi, Marwa S. Hany, Shaimaa A. Elsharif, Amal A. Eissa, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza. : Modulating the Cyclic Guanosine Monophosphate Substrate Selectivity of the Phosphodiesterase 3 Inhibitors by Pyridine, Pyrido[2,3-d]pyrimidine Derivatives and Their Effects upon the Growth of HT-29 Cancer Cell Line. , Chem Pharm Bull (Tokyo)., 2013.
61, 405-10 | Journal 2013 | Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.Reem K. Arafa,, Gehan H. Hegazy, Gary A. Piazza, Ashraf H. Abadi. : Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents. , Eur J Med Chem, 2013.63 826-32 | Journal 2013 | Development And Validation Of A Stability Indicatimg HPLC Method For The Simultaneous Determination Of Captopril And Indapamide.Bahia Abbas Moussa, Ashraf Hassan Abadi, Hanan Abou Youssef, Marianne Alphonse Mahrouse : Development And Validation Of A Stability Indicatimg HPLC Method For The Simultaneous Determination Of Captopril And Indapamide. , Anal. Chem. (an Indian Journal), 2013.
12, 131-136 |
2012Journal 2012 | Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors.Ashraf H. Abadi , Sahar M. Abou-Seri , Qingzhong Hu , Matthias Negri and Rolf W. Hartmann : Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors , Med. Chem. Commun., , 2012.
3, 663-666 | Journal 2012 | Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents Mohamed A. O. Abdelf-Fattah, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Bernard D. Gary, Gary A. Piazza and Ashraf H. Abadi : Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents , Med. Chem., 2012.
8, 392-400 | Journal 2012 | CoMFA and CoMSIA Studies of 1,2-Dihydropyridine Derivatives as Anticancer Agents.Ismail Salama, Mohamed A. O. Abdel-Fattah, Marwa S. Hany, Shaimaa A. El-Sharif, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Gary A. Piazza and Ashraf H. Abadi : CoMFA and CoMSIA Studies of 1,2-Dihydropyridine Derivatives as Anticancer Agents , Med. Chem., 2012.
8, 372-83. | Journal 2012 | A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity.
Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. : A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. , Cancer Prev Res (Phila)., 2012.
5, 822-33 | Book Chapter 2012 | Prospects for Chemoprevention of Colorectal Neoplasia: Emerging Role of Anti-Inflammatory Drugs-New targets and NSAID derivatives for colorectal cancer chemoprevention.Tinsley, H.N., Grizzle, W.E., Abadi, A., Xi, L., and Piazza, G.A : Prospects for Chemoprevention of Colorectal Neoplasia: Emerging Role of Anti-Inflammatory Drugs-New targets and NSAID derivatives for colorectal cancer chemoprevention , Springer-Verlag, 2012.
ISBN 978-3-642-30330-2 http://www.springer.com/medicine/oncology/book/978-3-642-30330-2 | Conference 2012 | A novelSulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity.
Jason D. Whitt, Nan Li, Heather N. Tinsley, Xi Chen, Wei Zhang, Yonghe Li, Bernard D. Gary, Adam B. Keeton, Yaguang Xi, Ashraf H. Abadi, William E. Grizzle, and Gary A. Piazza : A novelSulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. , Cyclic Nucleotide Phosphodiesterases- A Molecular Exploration of Cyclic-Nucleotide Action, 2012.
May 20-25, 2012, Renaissance Tuscany Il Ciocco Resort Lucca (Barga), Italy | Journal 2012 | New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention.
Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA : New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention. , Recent Results Cancer Res, 2012.
191, 105-20. | Journal 2012 | Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel ß-carboline derivatives
Nermin S. Ahmed, Amal H. Ali, Shreen M. El-Nashar, Bernard D. Gary, Alexandra M. Fajardo, Heather N. Tinsley, Gary A. Piazza, Matthias Negri, Ashraf H. Abadi : Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel ß-carboline derivatives , Eur J Med Chem, 2012.
57, 329-43 | Conference 2012 | Humboldt Conference Ashraf H. Abadi (conference chairman) : Humboldt Conference , Pharmaceutical and Biotechnological Therapies, 2012.
German University in Cairo, 28 September - 1 October 2012. | Conference 2012 | Engineering Inhibitors for Enzymes: Phosphodiesterase 5 A Study Case
Ashraf H. Abadi : Engineering Inhibitors for Enzymes: Phosphodiesterase 5 A Study Case , INTERNATIONAL CONFERENCE ON PHARMACEUTICAL SCIENCES , 2012.
Future University in Egypt, 13-14 April 2013, Cairo, Egypt | Conference 2012 | Phosphodiesterase 5 Inhibitors: a New Perspective.
Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors: a New Perspective. , The 1st International Conference on Science Diplomacy and Developments in Chemistry, , 2012.Alexandria University, 24-26 November 2012. |
2011Journal 2011 | Synthesis and Molecular Modeling of Novel tetrahydro-ß-Carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties
Heba A. Mohamed, Nancy M. R. Girgis, Rainer Wilcken, Matthias R. Bauer, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza, Frank M. Boeckler, Ashraf H. Abadi : Synthesis and Molecular Modeling of Novel tetrahydro-ß-Carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties , J Med Chem., 2011.
54, 495-509 | Journal 2011 | Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim, Mohamed S. M. Ali. : Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors , Int. J. Med. Chem, 2011.
Article ID 562421, 9 pages (2011), Doi:1155/2011/562421 | Journal 2011 | Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors
Nermin S. Ahmed, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Stefan Laufer, Ashraf H. Abadi : Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors , Arch Pharm (Weinheim). , 2011.
344, 149-57 | Conference 2011 | Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution
Mohammed Weam, Mohammad Abdel-Halim, Raimund Niess, Bernard D. Gary, Heather N. Tinsley, Jason Whitt, Gary A. Piazza, Matthias Engel, Rolf W. Hartmann, Ashraf H. Abadi : Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution , Frontiers in Medicinal Chemistry, 2011.
Saarbr?cken, Germany | Conference 2011 | A novel class of cGMP-specific phosphodiesterase inhibitors with highly potent in vitro tumor cell growth inhibitory activity and strong in vivo antitumor activity
Gary A. Piazza, Heather N. Tinsley, Bernard D. Gary, Meghan Knight, Wei Zhang, William Waud, Lori Coward, Greogry Gorman, Adam Keeton, Ashraf H. Abdi : A novel class of cGMP-specific phosphodiesterase inhibitors with highly potent in vitro tumor cell growth inhibitory activity and strong in vivo antitumor activity , American Association for Cancer Research, 102nd Annual Meeting, 2011.
Orange County Convention Center, Orlando, FL, USA | Patent 2011 | Tetrahydro-ß-carboline derivatives, synthesis and use thereof
Gary Piazza, Ashraf H. Abadi : Tetrahydro-ß-carboline derivatives, synthesis and use thereof , United States Patent and Trademark Office, 2011.
WO 2011063223 A1 May 26, 2011 WO 2010-US57410 Nov 19, 2010. Priority Application: US 2009-262989P P Nov 20, 2009 | Conference 2011 | A novel class of mono-alkylating agents with highly potent and selective tumor cell growth inhibitory activity
G. A. Piazza, H. N. Tinsley, B. D. Gary, M. R. Knight, N. Li, K. N. Tiwari, W. Zhang, W. R. Waud, L. U. Coward, G. Gorman, A. B. Keeton, R. F. Struck, A. H. Abadi : A novel class of mono-alkylating agents with highly potent and selective tumor cell growth inhibitory activity , Americam Society of Clinical Oncology, Annual 11th Meeting, 2011. | Conference 2011 | Phosphodiesterase 5 Inhibitors for Erectile Dysfunction and Beyond
Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors for Erectile Dysfunction and Beyond , Humboldt - Kolleg:Research to Applications & Markets, 2011.
Oral Presentation | Conference 2011 | New potential scaffolds for MDM2 inhibitors: Synthesis and bioassays.
Ashraf H. Abadi : New potential scaffolds for MDM2 inhibitors: Synthesis and bioassays. , Mini-symposium on "Frontiers in Cancer Biology & Therapy - Molecules, Targets, Systems". , 2011.
University of T?bingen, Germany, 7 December 2012. |
2010Journal 2010 | Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. Ashraf H. Abadi, Dalal A Abouel-Ella, Jochen Lehmann, Heather N Tinsley, Bernard D Gary, Gary A. Piazza, Mohamed A.O. Abdel-Fattah : Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach , Eur J Med Chem., 2010.
45, 90-97 | Journal 2010 | Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. Ashraf H. Abadi, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Mohammad Abdel-Halim : Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective , Eur J Med Chem., 2010.
45, 1278-86 | Journal 2010 | One-pot synthesis of 4,6-diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38alpha MAP kinase inhibition
Aya M. Serry, Sabine Luik, Stefan Laufer, Ashraf H. Abadi : One-pot synthesis of 4,6-diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38alpha MAP kinase inhibition , J Comb Chem., 2010.
12, 559-65 | Journal 2010 | Spectroscopic and chromatographic determination of fluvastatin sodium in presence of its acid degradate
Bahia A. Moussa, Ashraf H. Abadi, Hanan E. Abou-Youssef, Marianne A. Mahrouse : Spectroscopic and chromatographic determination of fluvastatin sodium in presence of its acid degradate , Int J. PharmTech Res , 2010.
2, 875-898 | Journal 2010 | A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors
Nermin S. Ahmed, Bernard D. Gary, Gary A. Piazza, Heather n. Tinsley, Ashraf H. Abadi : A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors , Med Chem. , 2010.
6, 374-387 | Journal 2010 | Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands.Noha A. Osman. Amr H. Mahmoud, Mario Allarà, Raimund Niess, Khaled A. Abouzid, Vincenzo Di Marzo, Ashraf H. Abadi, : Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands , Bioorg Med Chem., 2010.
18, 8463-8477 | Conference 2010 | Computational Insight: Oral Phosphodiesterase 5 Inhibitors for the Treatment of Erectile Dysfunction. Ashraf H. Abadi : Computational Insight: Oral Phosphodiesterase 5 Inhibitors for the Treatment of Erectile Dysfunction , North African Conference on Computational Physics and Chemistry, 2010.
Oran, Algeria (Invited speaker). | Technical Report 2010 | Phosphodiesterase 5 Inhibitors.Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors , Presentation, 2010.
University of Saarland, Germany, (Visiting Professor Lecture). | Conference 2010 | Novel cGMP elevating agent displaying highly potent and selective anticancer properties.Ashraf Abadi, Amira El-Amir, Meghan Knight, Heather Tinsley, Bernard Gary, Adam Keeton, gary Piazza : Novel cGMP elevating agent displaying highly potent and selective anticancer properties , International Conference on Molecular and Clinical Oncology, 2010.
German University in Cairo, Cairo, Egypt |
2009Journal 2009 | Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Ashraf H. Abadi, Tamer M. Ibrahim, Khaled M. Abouzid, Jochen Lehmann, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza : Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors , Bioorg. Med. Chem., 2009.
17, 5974-5982 | Journal 2009 | Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents. Ashraf H. Abadi, Dalal A. Abouel-Ella, Nermin S. Ahmed, Bernard D. Gary, Jose T. Thaiparambil, Heather N. Tinsley, Adam B. Keeton, Gary A. Piazza : Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents , Arzneimittel Forschung/Drug Research , 2009.
59, 415-421 | Journal 2009 | Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Heather N. Tinsley, Bernard D. Gary, Adam B. Keeton, Wei Zhang, Ashraf H. Abadi, Robert C. Reynolds, Gary A. Piazza : Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G , Mol Cancer Therap., 2009.
8, 3331-40 | Conference 2009 | Novel Tadalafil Analogues with New Stereochemical Perspective. Ashraf H. Abadi, Mohamed Saleh, Mohammad Abdel-Halim, Jochen Lehmann, Gary A. Piazza : Novel Tadalafil Analogues with New Stereochemical Perspective , German Pharmaceutical Society Annual Meeting, 2009.
Jena, Germany (special visiting guest). | Conference 2009 | Discovery of Novel Phosphodiesterase 3 and Colon Tumour Growth Inhibitory Agents through a Combinatorial Approach. Mohamed A. O. Abdel-Fattah, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza, Dalal A. Abouel-Ella, Jochen Lehamnn, Ashraf H. Abadi : Discovery of Novel Phosphodiesterase 3 and Colon Tumour Growth Inhibitory Agents through a Combinatorial Approach , German Pharmaceutical Society Annual Meeting, 2009.
Jena, Germany (special visiting guest). | Conference 2009 | Up-regulation of the Guardian of the Genome by Small Organic Molecules, A New Approach for Cancer Therapy. Ashraf H. Abadi : Up-regulation of the Guardian of the Genome by Small Organic Molecules, A New Approach for Cancer Therapy , 5th International Conference of Scientific Research and Its Applications, 2009.
Cairo University, Egypt (Invited speaker). | Conference 2009 | Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents Ashraf H. Abadi, Mohammed Abdel-halim, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza : Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents , Dubai International Pharmaceuticals and Technologies (Duphat), 2009.
Dubai, UAE |
2008Conference 2008 | Shortcuts to the Discovery of New Drugs. Ashraf H. Abadi : Shortcuts to the Discovery of New Drugs , the 1st Conference for the development of the Pharmaceutical Industry and Health Care in Egypt, 2008.
Cairo International Conference Centre, Cairo, Egypt (Invited speaker). |
2007Journal 2007 | Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand.Fadi M. Awadallah, Franziska Mueller, Jochen Lehmann, Ashraf H. Abadi, : Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand , Bioorg. Med. Chem. , 2007.
15, 5811-5818 |
2006Journal 2006 | Synthesis of 3-Substituted-2-Oxoindole Analogues and Their Evaluation as Kinase Inhibitors, Anticancer and Antiangiogenic Agents.Ashraf H. Abadi, Sahar M. Abou-Seri, Doaa E. Abdel-Rahman, Christian Klein, Olivier Lozach, Laurent Meijer : Synthesis of 3-Substituted-2-Oxoindole Analogues and Their Evaluation as Kinase Inhibitors, Anticancer and Antiangiogenic Agents , Eur. J. Med. Chem., 2006.
41, 296-305 | Journal 2006 | Simultaneous Determination of Indapamide and Captopril in Binary Mixtures by Derivative Spectrophotometry and TLC Densitometry.Bahia A. Moussa, Ashraf H. Abadi, Hanan E. Abou-Youssef and Marianne A. Mahrouse : Simultaneous Determination of Indapamide and Captopril in Binary Mixtures by Derivative Spectrophotometry and TLC Densitometry , Bull. Fac. Pharm. Cairo Univ., 2006.
44, 63-76 |
2005Journal 2005 | Synthesis of Novel 4-Substituted-7-trifluoromethylquinoline Derivatives With Nitric Oxide Releasing Properties and Their Evaluation As Analgesic and Antiinflammatory Agents.Ashraf H. Abadi, Gehan H. Hegazy, Asmaa A. El-Zaher : Synthesis of Novel 4-Substituted-7-trifluoromethylquinoline Derivatives With Nitric Oxide Releasing Properties and Their Evaluation As Analgesic and Antiinflammatory Agents , Bioorg. Med. Chem., 2005.
13, 5759-5765 | Journal 2005 | Densitometric Determination of Some Bronchodilators in Inhaler Meterd Aerosols
Sonia T. Hassib, Ashraf H. Abadi, Nadia F. Youssef and Hanan A. Ahmed : Densitometric Determination of Some Bronchodilators in Inhaler Meterd Aerosols , Bull. Fac. Pharm. Cairo Univ., 2005.
45, 79-86 | Journal 2005 | Synthesis and Virtual Screening of novel ß-Carboline Analogues as Potential Phosphodiesterase 5 Inhibitors.Ashraf H. Abadi : Synthesis and Virtual Screening of novel ß-Carboline Analogues as Potential Phosphodiesterase 5 Inhibitors , Bull. Fac. Pharm. Cairo Univ., 2005.
45, 283-289 |
2004Journal 2004 | Phenylpiperazinylmethylheterocycle Derivatives: Synthesis and Dopamine Receptor Binding Profiles.A. H. Abadi, : Phenylpiperazinylmethylheterocycle Derivatives: Synthesis and Dopamine Receptor Binding Profiles , Arch. Pharm. Pharm. Med. Chem., 2004.
337, 383-390 | Journal 2004 | Synthesis and Antitubercular Activity of 6-Chloro (Unsubstituted)-2-Methoxy-9-Substituted Acridine Derivatives.Enayat I. Aly, Ashraf H. Abadi, : Synthesis and Antitubercular Activity of 6-Chloro (Unsubstituted)-2-Methoxy-9-Substituted Acridine Derivatives , Arch. Pharm. Res. , 2004.
27, 713-719 | Conference 2004 | Shortcuts to Blockbuster Drugs. Cairo, Egypt (Invited speaker). : Shortcuts to Blockbuster Drugs , IXXX Conference of the Egyptian Pharmaceutical Society, 2004. |
2003Journal 2003 | Synthesis of Novel 1,3,4-Trisubstituted Pyrazole Derivatives and Their Evaluation as Antitumor and Antiangiogenic Agents. Ashraf H. Abadi, Amal A.H. Eissa, Ghaneya S. Hassan, : Synthesis of Novel 1,3,4-Trisubstituted Pyrazole Derivatives and Their Evaluation as Antitumor and Antiangiogenic Agents , Chem. Pharm. Bull. (Tokyo), 2003.
51, 838-844 | Journal 2003 | Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents. Ashraf H. Abadi, Reto Brun : Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents , Arzneim.-Forsch./Drug Res, 2003.
53, 655-663
2002 |
2002Journal 2002 | Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist. Ashraf H. Abadi, Stefan Lankow, Barbara Hoefgen, Michael Decker, Matthias U. Kassack, Jochen Lehmann : Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist , Arch. Pharm. Pharm. Med. Chem., 2002. 335, 367-73 |
2001Journal 2001 | Synthesis and cyclooxygenase inhibitory properties of novel (+) 2-(6-methoxy-2-naphthyl)propanoic acid (naproxene) derivatives. Ashraf H. Abadi, Stefan Laufer, Jochen Lehmann : Synthesis and cyclooxygenase inhibitory properties of novel (+) 2-(6-methoxy-2-naphthyl)propanoic acid (naproxene) derivatives , Arch. Pharm. Pharm. Med. Chem. , 2001.
334, 104-106 |
2000Journal 2000 | Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist. Ashraf H. Abadi, Stefan Lankow, Barbara Hoefgen, Michael Decker, Matthias U. Kassack, Jochen Lehmann : Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist , Arch. Pharm. Pharm. Med. Chem., 2002. 335, 367-73 | Journal 2000 | The voltammetric study and determination of ramipril in dosage forms and biological fluids. Abulrahma Al-Majed, Ashraf Abadi, Fatthallah Belal, Abelrahman Al-Obaid : The voltammetric study and determination of ramipril in dosage forms and biological fluids , IL Farmaco, 2000.
55, 233-38 | Conference 2000 | A Traceless Linking Approach to the Solid Phase Synthesis of Novel Potent Dopamine D4 Receptor Ligands. Ashraf H. Abadi, Stefab Loeber, Harlad Huebner, Peter Gmeiner : A Traceless Linking Approach to the Solid Phase Synthesis of Novel Potent Dopamine D4 Receptor Ligands , 10th Oesterreichische Chemietage Conference, 2000.
University of Linz, Austria. | Workshop 2000 | Molecular Simulation Incorporation (Currently Accelrys). Ashraf H. Abadi : Molecular Simulation Incorporation (Currently Accelrys) , From Gene to Lead: Integrated Drug Discovery, 2000. Frankfurt, Germany November 2000 | Conference 2000 | NO-NSAIDs. Ashraf H. Abadi, Jochen Lehmann : NO-NSAIDs , International Nitrate Conference, 2000. University of Duesseldorf, Düsseldorf, Germany. |
1999Journal 1999 | Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs. Hussein I. El-Subbagh, Ashraf H. Abadi, Ibrahim E. Al- Khawad, Khaled A. Al-Rashood : Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs , Arch. Pharm. Pharm. Med. Chem., 1999. 332, 19-24 | Journal 1999 | Synthesis, antitumor and antitubercular evaluation of certain new tricyclic planar xanthenones and acridinones. Ashraf H. Abadi, Hussein I. El-Subbagh, Hamd A. Al-Khamees : Synthesis, antitumor and antitubercular evaluation of certain new tricyclic planar xanthenones and acridinones , Arzneim.-Forsch./Drug Res., 1999.
49, 259-66 | Journal 1999 | 2,4-disubstituted-thiazoles III. Synthesis and antitumor activity of ethyl 2-substituted-aminothiazole-4-carboxylate analogs. Hussein I. El-Subbagh, Ashraf H. Abadi, Jochen Lehmann, : 2,4-disubstituted-thiazoles III. Synthesis and antitumor activity of ethyl 2-substituted-aminothiazole-4-carboxylate analogs , Arch. Pharm. Pharm. Med. Chem. , 1999.
332, 137-42 | Journal 1999 | Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres, as non steroidal cardiotonic agents. Ashraf Abadi, Omar Al-Deeb, Ahmed Al-Afify, Hassan El-Kashef : Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres, as non steroidal cardiotonic agents , IL Farmaco, 1999.
54, 195-201 | Journal 1999 | Chlorpromazine. Ashraf H. Abadi, Sayed R. Allah, Abdullah A. Al-Badr : Chlorpromazine , Analytical Profile of Drug Substances and Excipients , 1999.
26, 97-165 |
1998Journal 1998 | New antineoplastic agents with high selectivity towards leukemia cell lines. Ashraf H. Abadi and Hamad A. Al-Khamees, 3-cyano-4,6-disubstituted-2(1H)-imino or oxopyridines : New antineoplastic agents with high selectivity towards leukemia cell lines , Arch. Pharm. Pharm. Med. Chem. , 1998.
331, 319-24 | Journal 1998 | 5-Substituted-2-bromoindolo[3,2-b]quinoxalines. A class of potential antitumor agents with cdc25 phosphatase inhibitory properties.Ashraf H. Abadi : 5-Substituted-2-bromoindolo[3,2-b]quinoxalines. A class of potential antitumor agents with cdc25 phosphatase inhibitory properties , Arch. Pharm. Pharm. Med. Chem., 1998.
331, 352-58 |
1997Journal 1997 | Synthesis and antitumor activity of 9- anilino, phenylhydrazino and sulphonamido analogs of 2- or 4-methoxy-6-nitroacridines. Hussein I. El-Subbagh, Ashraf H. Abadi, Hamad A. Al-Khamees : Synthesis and antitumor activity of 9- anilino, phenylhydrazino and sulphonamido analogs of 2- or 4-methoxy-6-nitroacridines , Arch. Pharm. Pharm. Med. Chem. , 1997.
330, 277-84 | Journal 1997 | Synthesis and pharmacological evaluation of some 3-[(4-aryl- and benzylpiperazinyl)alkoxy]-2-methyl -4-(3H)-quinazolinones as potential neuroleptic agents.Ashraf H. Abadi, Hamad A. Al-Khamees, Omar A. Al-Deeb, Mohei M. Elmazar, Abdulrahman M.Ageel : Synthesis and pharmacological evaluation of some 3-[(4-aryl- and benzylpiperazinyl)alkoxy]-2-methyl -4-(3H)-quinazolinones as potential neuroleptic agents , Sci. Pharm., 1997.
65, 113-130 |
1995Journal 1995 | Spectrophotometric determination of some cardiovascular drugs.Hamed A. Abu-Shady, Sonia T. Hassib, Hassanein H. Hassanein, Ashraf H. Abadi , : Spectrophotometric determination of some cardiovascular drugs , Egypt. J. Pharm. Sci. , 1995.
36, 393-405 |
1994Journal 1994 | LC determination of celiprolol, diltiazem desmethyldiltiazem and deacetyldiltiazem. David R. Rutledge, Ashraf H. Abadi, Larry M. Lpoez : LC determination of celiprolol, diltiazem desmethyldiltiazem and deacetyldiltiazem , J. Pharm. Biomed. Anal. , 1994.12, 135-40 | Journal 1994 | Simultaneous determination of verapamil and celiprolol in human plasma. David R. Rutledge, Ashraf H. Abadi, Larry M. Lopez : Simultaneous determination of verapamil and celiprolol in human plasma , J. Chromatogr. Sci. , 1994.
32, 153-56 | Journal 1994 | Determination of nifedipine and its photodegradation product in pharmaceutical preparation. Hamed A. Abu-Shady, Sonia T. Hassib, Hassanein H. Hassanein, Ashraf H. Abadi : Determination of nifedipine and its photodegradation product in pharmaceutical preparation , Bull. Fac. Ph, . Cairo Univ, 1994.
32, 193-98 |
1993Journal 1993 | Focus on bisoprolol: A once daily beta-blocker providing 24-hour blood pressure control with balanced renal and hepatic elimination. Stephan M. Steinwandt, Ashraf H. Abadi, David R. Rutledge : Focus on bisoprolol: A once daily beta-blocker providing 24-hour blood pressure control with balanced renal and hepatic elimination , Hosp. Formul., 1993.
28, 453-63 | Journal 1993 | High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column. David R. Rutledge, Ashraf H. Abadi, Larry M. Lopez, Charles A. Beaudreau : High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column , J. Chromatogr., 1993.
513, 111-16 |
1992Workshop 1992 | DNA sequencing methodology and PCR techniques course. Ashraf H. Abadi : DNA sequencing methodology and PCR techniques course , The Canter for Advanced Training in Cell and Molecular Biology, 1992.
Lake Taho, CA, U.S.A. | Workshop 1992 | Basic radiation safety course. Ashraf H. Abadi : Basic radiation safety course , safety course, 1992.
University of Florida, FL, U.S.A |
|