Information for:

Pharmaceutical Chemistry

Head of Pharmaceutical Chemistry Department
Prof. Dr. Ashraf Abadi

Email: ashraf.abadi@guc.edu.eg
Office:B5-106
Ext: 3400

Biography	Ashraf Abadi is Full Professor and Head of the Department of Pharmaceutical Chemistry at the German University in Cairo. He also served as the Dean of the faculty (2011-2016). In addition, he was a full professor in Pharmacy, Cairo University from 2006-2016. He studied Pharmacy in Cairo University and received his Master and Ph.D. in Pharmaceutical Chemistry from the Cairo University and the University of Florida, USA. He worked as a visiting professor in King Saud University, Saudi Arabia, and Universities of Bonn, Erlangen, Jena and Saarland, Ulm and Tubingen, in Germany. He is an Alexander von Humboldt (AvH) fellow as well as DAAD fellow since 1999 and served as Ambassador Scientist of the Alexander von Humboldt foundation in Egypt (2010-2015). He has a track record of >90 publications in impact international journals, 7 international patents and patents applications, and served as a referee and editorial board member for many International organizations and Scientific journals. He supervised more than seventy Master and Doctoral theses. In addition he is a recipient of so many national and international awards and grants. He is a member of the American Chemical Society, the Egyptian Syndicate of Pharmacy and the Arab Pharmacists Union. His research interests are synthetic Medicinal Chemistry and Computer Aided Drug Design.
Research Interests
1. Medicinal Chemistry 2. Computer Aided Drug Design 3. Pharmaceutical and Biomedical Analysis 4. Mechanisms of action of Pharmaceuticals

Publications

2020

Journal 2020	Mirja Harms, Monica MW Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B, 2020, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2020.12.005.
Journal 2020	Abdel-Halim M, Tinsley H, Keeton AB, Weam M, Atta NH, Hammam MA, Hefnawy A, Hartmann RW, Engel M, Piazza GA, Abadi AH. Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors. Bioorg Chem. 2020 Nov;104:104322. doi: 10.1016/j.bioorg.2020.104322.
Journal 2020	Abdel Karim SE, Youssef YH, Abdel-Halim M, Frakolaki E, Vassilaki N, Zoidis G, Ahmed NS, Abadi AH. Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates. Bioorg Chem. 2020 Sep;102:104089. doi: 10.1016/j.bioorg.2020.104089.
Journal 2020	Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M. Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents. Bioorg Chem. 2020 Jun;99:103759. doi: 10.1016/j.bioorg.2020.103759.
Journal 2020	ElHady AK, Shih SP, Chen YC, Liu YC, Ahmed NS, Keeton AB, Piazza GA, Engel M, Abadi AH, Abdel-Halim M. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742. doi: 10.1016/j.bioorg.2020.103742.

2019

Journal 2019	Wadea NE, Issac MM, Osman NA, Abadi AH. Benzofuran and pyrrole derivatives as cannabinoid receptor modulators with in vivo efficacy against ulcerative colitis. Future Med Chem. 2019 Dec;11(24):3139-3159. doi: 10.4155/fmc-2019-0172.
Journal 2019	Leila ARS, Mousa MHA, Frakolaki E, Vassilaki N, Bartenschlager R, Zoidis G, Abdel-Halim M, Abadi AH. Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds. ACS Omega. 2019 Jul 1;4(7):11440-11454. doi: 10.1021/acsomega.9b01242.
Journal 2019	Ghonim AE, Ligresti A, Rabbito A, Mahmoud AM, Di Marzo V, Osman NA, Abadi AH. Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties. Eur J Med Chem. 2019 Oct 15;180:154-170. doi: 10.1016/j.ejmech.2019.07.002.

2018

Journal 2018	Darwish SS, Abdel-Halim M, ElHady AK, Salah M, Abadi AH, Becker W, Engel M. Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification. Eur J Med Chem. 2018 Oct 5;158:270-285. doi: 10.1016/j.ejmech.2018.08.097.
Journal 2018	Darwish SS, Abdel-Halim M, Salah M, Abadi AH, Becker W, Engel M. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. Eur J Med Chem. 2018 Sep 5;157:1031-1050. doi: 10.1016/j.ejmech.2018.07.050
Journal 2018	Abdel-Halim M, Abadi AH, Engel M. Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ). Medchemcomm. 2018 May 7;9(6):1076-1082. doi: 10.1039/c8md00100f.
Journal 2018	Ramsis TM, Abdel Karim SE, Vassilaki N, Frakolaki E, Kamal AAM, Zoidis G, Ahmed NS, Abadi AH. Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches. Arch Pharm (Weinheim). 2018 Jul;351(7):e1800017. doi: 10.1002/ardp.201800017.
Journal 2018	El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH. Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors. Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018.

2017

Journal 2017	ElHady AK, Abdel-Halim M, Abadi AH, Engel M. Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. J Med Chem. 2017 Jul 13;60(13):5377-5391. doi: 10.1021/acs.jmedchem.6b01915.
Journal 2017	Hamed MM, Darwish SS, Herrmann J, Abadi AH, Engel M. First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents. J Med Chem. 2017 Apr 13;60(7):2853-2868. doi: 10.1021/acs.jmedchem.6b01774.

2016

Journal 2016	Structure-based design of novel tetrahydro-beta-carboline derivatives with a hydrophilic side chain as potential phosphodiesterase inhibitors. Ahmed K. Elhady, Sara C. Sigler, Nazih Noureldin, Joshua C. Canzoneri, Nermin S. Ahmed, Gary A. Piazza, Ashraf H. Abadi, Sci Pharm, 2016. in press. doi:10.3797/scipharm.1507-16
Journal 2016	Design and Synthesis of Novel Flexible Ester-containing Analogues of Tamoxifen and Their Evaluation as Anticancer Agents. Nehal H. Elghazawy, Mathias Engel Rolf W. Hartmann, Mostafa M. Hamed, Nermin S. Ahmed, Ashraf H. Abadi, Future Medicinal Chemistry, 2016. 8(3), 249-56 (2016)
Journal 2016	Synthesis and Optimization of New 3,6-disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. Mohamed SalahRezk, Mohammad Abdel-Halim, Adam Keeton, DerekFranklin, Matthias Bauer, Frank Michael Boeckler,Matthias Engel, Rolf Wolfgang Hartmann,Yanping Zhang, Gary Anthony Piazza, Ashraf HassanAbadi.Chemical and Pharmaceutical bulletin (Tokyo), 2016. 64(1), 34-41 (2016).
Journal 2016	Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism Ahmed NS, Elghazawy NH, ElHady AK, Engel M, Hartmann RW, Abadi AH, Eur J Med Chem. , 2016.112:171-9 (2016).
Conference 2016	Personalized or Impersonalized: That is the Question. Ashraf H. Abadi. Faculty of Pharmacy, Cairo University, 7th International Scientific Conference, 2016. Keynote speaker
Conference 2016	Design and Synthesis of Novel Tamoxifen Analogues and tehir Evaluation as Sepective Estrogen Receptor Modulators, Ashraf. H. Abadi, Nermin S. Ahmed, Rasha M. Rashied, G?nter Vollmer, Jannette Wober, Faculty of Pharmacy, Cairo University, 7th International Scientific Conference. , 2016. poster presentation. Best Poster Award
Conference 2016	Approaches to Computer-Aided Drug Design and Drug Re-positioning Ashraf. H. Abadi, Arab-African Pharma Conference, Cairo,Egypt 5-7 May 2016. , 2016. Keynote Speaker
Conference 2016	Design and Synthesis of Novel Non CYP 2D6 mediated Tamoxifen Analogues. Nehal H. Elghazawy, Nermin S. Ahmed, Bianca Liederer, Rolf Hartmann, Ashraf. H. Abadi.Pharmaceutics & Novel Drug Delivery Systems. March 07-09, 2016 Madrid, Spain., 2016. Poster presentation. best poster award
Conference 2016	Clinical Pharmacy Session, Ashraf H. Abadi : Clinical Pharmacy Session , Breast Gynecological International Cancer Conference, Clinical Pharmacy, 2016. Chairperson
Journal 2016	Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M. Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016.
Journal 2016	Osman NA, Ligresti A, Klein CD, Allarà M, Rabbito A, Di Marzo V, Abouzid KA, Abadi AH. Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality. Eur J Med Chem. 2016 Oct 21;122:619-634. doi: 10.1016/j.ejmech.2016.07.012.

2015

Conference 2015	At the Cross line between Celecoxib and Sildenafil. Ashraf H. Abadi. : At the Cross line between Celecoxib and Sildenafil. ,3rd FUE-International Conference on Pharmaceutical Sciences., 2015.Cairo, Egypt. February 2015.
Conference 2015	A novel celecoxib derivative that lacks COX-2 inhibition but displays potent colon tumor cell growth and PDE5 inhibitory activity Sara C. Sigler, Veronica Ramirez-Alcantara, Adam B. Keeton, Mohammad Abdel-Halim, Ashraf H. Abadi, Gary A. Piazza , American association for Cancer Research AACR annual meeting., 2015. Pennsylvania, USA. April 2015.
Conference 2015	Internationalization of Science and Research in Egypt. Ashraf H. Abadi : Internationalization of Science and Research in Egypt , Europe and Mediterranean Regions: History, Emergencies, and Chances, 2015. Lecce, Italy. April 2015
Patent 2015	Allosteric Inhibitors of Atypical Protein Kinases C Matthias Engel, Mohammad Abdel-Halim and Ashraf H. Abadi : Allosteric Inhibitors of Atypical Protein Kinases C , - , 2015. PCT WO/2015/075051
Journal 2015	D1-like receptors distinguishing thieno-azecine regioisomers.Abdel-Fattah, Mohamed A. O.; Abadi, Ashraf H.; Lehmann, Jochen; Schweikert, Peter M.; Enzensperger, Christoph. : D1-like receptors distinguishing thieno-azecine regioisomers. , MedChemComm, 2015. 6, 1679-1686 (2015).
Journal 2015	Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents. Habib MM, Abdelfattah MA, Abadi AH. Agents , Arch Pharm (Weinheim)., 2015. 348, 868-74 (2015)
Journal 2015	Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. Hassaan EA, Sigler SC, Ibrahim TM, Lee KJ, Cichon LK, Gary BD, Canzoneri JC, Piazza GA, Abadi AH. : Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach , Med Chem, 2015. Dec 3. [Epub ahead of print]

2014

Conference 2014	A novel series of celecoxib derivatives lacking COX-2 inhibitory activity more potently inhibits cancer cell growth by inhibiting PDE5. Sara C. Sigler, Veronica Ramirez, Ashraf Abadi, Gary Piazza : A novel series of celecoxib derivatives lacking COX-2 inhibitory activity more potently inhibits cancer cell growth by inhibiting PDE5. , American Association for Cancer Research (AACR), annual meeting, 2014. San Diego, USA. 5-9 April 2014
Journal 2014	1,3,5-trisubstituted pyrazolines as potent and highly selective inhibitors of protein kinasce C-zeta. Mohammad Abdel-Halim, Britta diesel , Alexandra K. Kiemer, Ashraf H. Abadi, Rolf W. Hartmann, Matthias Engel : 1,3,5-trisubstituted pyrazolines as potent and highly selective inhibitors of protein kinasce C-zeta. , J. Med. Chem, 2014. 57, 6513-30 (2014).
Journal 2014	Design and Synthesis of Novel Quinazoline Derivatives and Their Evaluation as PI3Ks Inhibitors.Omar Maged El-Said, Mostafa Mohamed Hamed, Stefan Laufer, Ashraf Hassan Abadi. : Design and Synthesis of Novel Quinazoline Derivatives and Their Evaluation as PI3Ks Inhibitors , Chem Pharm. Bull. (Tokyo). , 2014. 2014;62(12):1166-72
Journal 2014	Naphtahlene and 2,3-dihydrobenzo[b][1,4]dioxin Derivatives With Extended Side Chains as New Scaffolds of CB2 Selective Ligands. Noha A. Osman, Amr H. Mahmoud, Christian D. Klein, Marco Allaràd, Vincenzo Di Marzod, Khaled M. Abouzid, Ashraf H. Abadi : Naphtahlene and 2,3-dihydrobenzo[b][1,4]dioxin Derivatives With Extended Side Chains as New Scaffolds of CB2 Selective Ligands. , MedChem Comm, 2014.5, 1571-157 (2014).
Journal 2014	An Efficient and Green One-Pot Synthesis of Novel Spirooxindole Derivatives with Potential Anti-tumor Activity in an Aqueous Solvent. abadi chem rapid comm 2014_2.pdf Lobna M. Elwarraky, Mohamed A. O. Abdel-Fattaha, Bernard D. Gary, Gary A. Piazzab, Ashraf H. Abadi : An Efficient and Green One-Pot Synthesis of Novel Spirooxindole Derivatives with Potential Anti-tumor Activity in an Aqueous Solvent. , Chem rapid Comm, 2014. 2, 33-40 (2014).
Journal 2014	Spectrophotometric Determination of Imatinib Mesylate using Charge Transfer Complexs in Pure Form and Pharmaceutical Formulation abadi chem rapid comm 2014.pdf Shereen. E. Abdel Karim, Raafat. A. Farghaly, Rasha. M. El-Nashar, Ashraf. H. Abadi : Spectrophotometric Determination of Imatinib Mesylate using Charge Transfer Complexs in Pure Form and Pharmaceutical Formulation , Chem Rapid Comm, 2014.2, 55-63 (2014)
Journal 2014	Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt. Rasha S. Hanafi, Mansour S. Mohamed, Mohamed Ashour, Mona Z. El-Readi, Said Y. Desouky, Raimnd R. Niess, Ashraf H. Abadi, Michael M. Wink : Chemical Composition and Biological Activity of Essential Oils of Cumin and Coriander Fruits from Egypt , Nat. Prod. J. , 2014. 4, 63-69 (2014).
Conference 2014	Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. Ashraf H. Abadi, Engi Engi A. Hassan, Gary A. Piazza : Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. , International Scientific Committee. Humboldt-Kolleg / International Conference of Theory and Computation in Sciences and Bio-Sciences. , 2014. Tlemcen, Algeria. November 2014
Conference 2014	Drug Discovery using Chemical Libraries.Ashraf H. Abadi. : Drug Discovery using Chemical Libraries. , Scientific Congress of teh Associations of Colleges of Pharmacy in the Arab World, 2014. Cairo, Egypt. October 2014
Workshop 2014	Intellectual property and Antiviral Medications. Ashraf H. Abadi : Intellectual property and Antiviral Medications , Fraunhofer Workshop on Infection Biology and Aquaculture, 2014. DAAD, Cairo, Egypt September 2014.
Conference 2014	Dual Inhibitors of Epidermal Growth factor receptor kinase and the NF-?B pathway as potential anti-cancer drugs with enhanced efficacy. Mostafa M. Hamed, Jennifer Hermann, Ashraf H. Abadi, Rolf W. Hartmann, Matthias Engel : Dual Inhibitors of Epidermal Growth factor receptor kinase and the NF-?B pathway as potential anti-cancer drugs with enhanced efficacy. , XXIII International Symposium on Medicinal Chemistry , 2014. Lisbon, Portugal September 2014
Conference 2014	A Novel Series of Celecoxib Derivatives that Inhibit PDE 5 but Lack COX-2 Inhibitory Activity Potently Inhibit Colon Cancer Cell Growth. Sara C. Sigler, Ashraf H. Abadi, and Gary A. Piazza : A Novel Series of Celecoxib Derivatives that Inhibit PDE 5 but Lack COX-2 Inhibitory Activity Potently Inhibit Colon Cancer Cell Growth. , Gordon research Conference, Cyclic Nucleotide Phosphodiesterases, Signaling Regulation in the Pathogenesis and Treatment of Disease, 2014.Massachussete, USA. 1-6 June 2014

2013

Journal 2013	Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes Azza T. Taher, Hanan H. Kadry, Marco Allarà, Vincenzo Di Marzo, Ashraf H. Abadi, Khaled A. Abouzid : Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes , J Enzy Inhibit Med Chem, 2013. 28, 436-439
Journal 2013	Functional evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells. Mai A. Saad Zaghloul, Ashraf H. Abadi, Ahmed I. Abdelaziz. : Functional evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells , Rec Patents Biomark, 2013. 3, 65-71
Journal 2013	Design of Novel ß-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors. Dalia S. El-Gamil, Nermin S. Ahmed, Bernard D. Gary, Gary A Piazza, Matthias Engel, Rolf W. Hartmann, Ashraf H. Abadi : Design of Novel ß-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors , Arch Pharm, 2013. 346, 23-33
Journal 2013	New NSAID targets and derivatives for colorectal cancer chemoprevention Heather N. Tinsley, William E. Grizzle, Ashraf Abadi, Adam Keeton, Bing Zhu, Yaguang Yen , Gary A. Piazza. : New NSAID targets and derivatives for colorectal cancer chemoprevention , Recent Results Cancer Res. , 2013. 191, 105-20
Journal 2013	Modulating the Cyclic Guanosine Monophosphate Substrate Selectivity of the Phosphodiesterase 3 Inhibitors by Pyridine, Pyrido[2,3-d]pyrimidine Derivatives and Their Effects upon the Growth of HT-29 Cancer Cell Line. Ashraf H. Abadi, Marwa S. Hany, Shaimaa A. Elsharif, Amal A. Eissa, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza. : Modulating the Cyclic Guanosine Monophosphate Substrate Selectivity of the Phosphodiesterase 3 Inhibitors by Pyridine, Pyrido[2,3-d]pyrimidine Derivatives and Their Effects upon the Growth of HT-29 Cancer Cell Line. , Chem Pharm Bull (Tokyo)., 2013. 61, 405-10
Journal 2013	Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.Reem K. Arafa,, Gehan H. Hegazy, Gary A. Piazza, Ashraf H. Abadi. : Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents. , Eur J Med Chem, 2013.63 826-32
Journal 2013	Development And Validation Of A Stability Indicatimg HPLC Method For The Simultaneous Determination Of Captopril And Indapamide.Bahia Abbas Moussa, Ashraf Hassan Abadi, Hanan Abou Youssef, Marianne Alphonse Mahrouse : Development And Validation Of A Stability Indicatimg HPLC Method For The Simultaneous Determination Of Captopril And Indapamide. , Anal. Chem. (an Indian Journal), 2013. 12, 131-136

2012

Journal 2012	Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors.Ashraf H. Abadi , Sahar M. Abou-Seri , Qingzhong Hu , Matthias Negri and Rolf W. Hartmann : Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors , Med. Chem. Commun., , 2012. 3, 663-666
Journal 2012	Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents Mohamed A. O. Abdelf-Fattah, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Bernard D. Gary, Gary A. Piazza and Ashraf H. Abadi : Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents , Med. Chem., 2012. 8, 392-400
Journal 2012	CoMFA and CoMSIA Studies of 1,2-Dihydropyridine Derivatives as Anticancer Agents.Ismail Salama, Mohamed A. O. Abdel-Fattah, Marwa S. Hany, Shaimaa A. El-Sharif, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Gary A. Piazza and Ashraf H. Abadi : CoMFA and CoMSIA Studies of 1,2-Dihydropyridine Derivatives as Anticancer Agents , Med. Chem., 2012. 8, 372-83.
Journal 2012	A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. : A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. , Cancer Prev Res (Phila)., 2012. 5, 822-33
Book Chapter 2012	Prospects for Chemoprevention of Colorectal Neoplasia: Emerging Role of Anti-Inflammatory Drugs-New targets and NSAID derivatives for colorectal cancer chemoprevention.Tinsley, H.N., Grizzle, W.E., Abadi, A., Xi, L., and Piazza, G.A : Prospects for Chemoprevention of Colorectal Neoplasia: Emerging Role of Anti-Inflammatory Drugs-New targets and NSAID derivatives for colorectal cancer chemoprevention , Springer-Verlag, 2012. ISBN 978-3-642-30330-2 http://www.springer.com/medicine/oncology/book/978-3-642-30330-2
Conference 2012	A novelSulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. Jason D. Whitt, Nan Li, Heather N. Tinsley, Xi Chen, Wei Zhang, Yonghe Li, Bernard D. Gary, Adam B. Keeton, Yaguang Xi, Ashraf H. Abadi, William E. Grizzle, and Gary A. Piazza : A novelSulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and ß-Catenin Transcriptional Activity. , Cyclic Nucleotide Phosphodiesterases- A Molecular Exploration of Cyclic-Nucleotide Action, 2012. May 20-25, 2012, Renaissance Tuscany Il Ciocco Resort Lucca (Barga), Italy
Journal 2012	New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention. Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA : New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention. , Recent Results Cancer Res, 2012. 191, 105-20.
Journal 2012	Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel ß-carboline derivatives Nermin S. Ahmed, Amal H. Ali, Shreen M. El-Nashar, Bernard D. Gary, Alexandra M. Fajardo, Heather N. Tinsley, Gary A. Piazza, Matthias Negri, Ashraf H. Abadi : Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel ß-carboline derivatives , Eur J Med Chem, 2012. 57, 329-43
Conference 2012	Humboldt Conference Ashraf H. Abadi (conference chairman) : Humboldt Conference , Pharmaceutical and Biotechnological Therapies, 2012. German University in Cairo, 28 September - 1 October 2012.
Conference 2012	Engineering Inhibitors for Enzymes: Phosphodiesterase 5 A Study Case Ashraf H. Abadi : Engineering Inhibitors for Enzymes: Phosphodiesterase 5 A Study Case , INTERNATIONAL CONFERENCE ON PHARMACEUTICAL SCIENCES , 2012. Future University in Egypt, 13-14 April 2013, Cairo, Egypt
Conference 2012	Phosphodiesterase 5 Inhibitors: a New Perspective. Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors: a New Perspective. , The 1st International Conference on Science Diplomacy and Developments in Chemistry, , 2012.Alexandria University, 24-26 November 2012.

2011

Journal 2011	Synthesis and Molecular Modeling of Novel tetrahydro-ß-Carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties Heba A. Mohamed, Nancy M. R. Girgis, Rainer Wilcken, Matthias R. Bauer, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza, Frank M. Boeckler, Ashraf H. Abadi : Synthesis and Molecular Modeling of Novel tetrahydro-ß-Carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties , J Med Chem., 2011. 54, 495-509
Journal 2011	Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim, Mohamed S. M. Ali. : Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors , Int. J. Med. Chem, 2011. Article ID 562421, 9 pages (2011), Doi:1155/2011/562421
Journal 2011	Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors Nermin S. Ahmed, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Stefan Laufer, Ashraf H. Abadi : Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-ß-carboline Derivatives as Novel PDE5 Inhibitors , Arch Pharm (Weinheim). , 2011. 344, 149-57
Conference 2011	Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution Mohammed Weam, Mohammad Abdel-Halim, Raimund Niess, Bernard D. Gary, Heather N. Tinsley, Jason Whitt, Gary A. Piazza, Matthias Engel, Rolf W. Hartmann, Ashraf H. Abadi : Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution , Frontiers in Medicinal Chemistry, 2011. Saarbr?cken, Germany
Conference 2011	A novel class of cGMP-specific phosphodiesterase inhibitors with highly potent in vitro tumor cell growth inhibitory activity and strong in vivo antitumor activity Gary A. Piazza, Heather N. Tinsley, Bernard D. Gary, Meghan Knight, Wei Zhang, William Waud, Lori Coward, Greogry Gorman, Adam Keeton, Ashraf H. Abdi : A novel class of cGMP-specific phosphodiesterase inhibitors with highly potent in vitro tumor cell growth inhibitory activity and strong in vivo antitumor activity , American Association for Cancer Research, 102nd Annual Meeting, 2011. Orange County Convention Center, Orlando, FL, USA
Patent 2011	Tetrahydro-ß-carboline derivatives, synthesis and use thereof Gary Piazza, Ashraf H. Abadi : Tetrahydro-ß-carboline derivatives, synthesis and use thereof , United States Patent and Trademark Office, 2011. WO 2011063223 A1 May 26, 2011 WO 2010-US57410 Nov 19, 2010. Priority Application: US 2009-262989P P Nov 20, 2009
Conference 2011	A novel class of mono-alkylating agents with highly potent and selective tumor cell growth inhibitory activity G. A. Piazza, H. N. Tinsley, B. D. Gary, M. R. Knight, N. Li, K. N. Tiwari, W. Zhang, W. R. Waud, L. U. Coward, G. Gorman, A. B. Keeton, R. F. Struck, A. H. Abadi : A novel class of mono-alkylating agents with highly potent and selective tumor cell growth inhibitory activity , Americam Society of Clinical Oncology, Annual 11th Meeting, 2011.
Conference 2011	Phosphodiesterase 5 Inhibitors for Erectile Dysfunction and Beyond Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors for Erectile Dysfunction and Beyond , Humboldt - Kolleg:Research to Applications & Markets, 2011. Oral Presentation
Conference 2011	New potential scaffolds for MDM2 inhibitors: Synthesis and bioassays. Ashraf H. Abadi : New potential scaffolds for MDM2 inhibitors: Synthesis and bioassays. , Mini-symposium on "Frontiers in Cancer Biology & Therapy - Molecules, Targets, Systems". , 2011. University of T?bingen, Germany, 7 December 2012.

2010

Journal 2010	Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. Ashraf H. Abadi, Dalal A Abouel-Ella, Jochen Lehmann, Heather N Tinsley, Bernard D Gary, Gary A. Piazza, Mohamed A.O. Abdel-Fattah : Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach , Eur J Med Chem., 2010. 45, 90-97
Journal 2010	Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. Ashraf H. Abadi, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Mohammad Abdel-Halim : Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective , Eur J Med Chem., 2010. 45, 1278-86
Journal 2010	One-pot synthesis of 4,6-diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38alpha MAP kinase inhibition Aya M. Serry, Sabine Luik, Stefan Laufer, Ashraf H. Abadi : One-pot synthesis of 4,6-diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38alpha MAP kinase inhibition , J Comb Chem., 2010. 12, 559-65
Journal 2010	Spectroscopic and chromatographic determination of fluvastatin sodium in presence of its acid degradate Bahia A. Moussa, Ashraf H. Abadi, Hanan E. Abou-Youssef, Marianne A. Mahrouse : Spectroscopic and chromatographic determination of fluvastatin sodium in presence of its acid degradate , Int J. PharmTech Res , 2010. 2, 875-898
Journal 2010	A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors Nermin S. Ahmed, Bernard D. Gary, Gary A. Piazza, Heather n. Tinsley, Ashraf H. Abadi : A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors , Med Chem. , 2010. 6, 374-387
Journal 2010	Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands.Noha A. Osman. Amr H. Mahmoud, Mario Allarà, Raimund Niess, Khaled A. Abouzid, Vincenzo Di Marzo, Ashraf H. Abadi, : Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands , Bioorg Med Chem., 2010. 18, 8463-8477
Conference 2010	Computational Insight: Oral Phosphodiesterase 5 Inhibitors for the Treatment of Erectile Dysfunction. Ashraf H. Abadi : Computational Insight: Oral Phosphodiesterase 5 Inhibitors for the Treatment of Erectile Dysfunction , North African Conference on Computational Physics and Chemistry, 2010. Oran, Algeria (Invited speaker).
Technical Report 2010	Phosphodiesterase 5 Inhibitors.Ashraf H. Abadi : Phosphodiesterase 5 Inhibitors , Presentation, 2010. University of Saarland, Germany, (Visiting Professor Lecture).
Conference 2010	Novel cGMP elevating agent displaying highly potent and selective anticancer properties.Ashraf Abadi, Amira El-Amir, Meghan Knight, Heather Tinsley, Bernard Gary, Adam Keeton, gary Piazza : Novel cGMP elevating agent displaying highly potent and selective anticancer properties , International Conference on Molecular and Clinical Oncology, 2010. German University in Cairo, Cairo, Egypt

2009

Journal 2009	Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Ashraf H. Abadi, Tamer M. Ibrahim, Khaled M. Abouzid, Jochen Lehmann, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza : Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors , Bioorg. Med. Chem., 2009. 17, 5974-5982
Journal 2009	Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents. Ashraf H. Abadi, Dalal A. Abouel-Ella, Nermin S. Ahmed, Bernard D. Gary, Jose T. Thaiparambil, Heather N. Tinsley, Adam B. Keeton, Gary A. Piazza : Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents , Arzneimittel Forschung/Drug Research , 2009. 59, 415-421
Journal 2009	Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Heather N. Tinsley, Bernard D. Gary, Adam B. Keeton, Wei Zhang, Ashraf H. Abadi, Robert C. Reynolds, Gary A. Piazza : Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G , Mol Cancer Therap., 2009. 8, 3331-40
Conference 2009	Novel Tadalafil Analogues with New Stereochemical Perspective. Ashraf H. Abadi, Mohamed Saleh, Mohammad Abdel-Halim, Jochen Lehmann, Gary A. Piazza : Novel Tadalafil Analogues with New Stereochemical Perspective , German Pharmaceutical Society Annual Meeting, 2009. Jena, Germany (special visiting guest).
Conference 2009	Discovery of Novel Phosphodiesterase 3 and Colon Tumour Growth Inhibitory Agents through a Combinatorial Approach. Mohamed A. O. Abdel-Fattah, Heather N. Tinsley, Bernard D. Gary, Gary A. Piazza, Dalal A. Abouel-Ella, Jochen Lehamnn, Ashraf H. Abadi : Discovery of Novel Phosphodiesterase 3 and Colon Tumour Growth Inhibitory Agents through a Combinatorial Approach , German Pharmaceutical Society Annual Meeting, 2009. Jena, Germany (special visiting guest).
Conference 2009	Up-regulation of the Guardian of the Genome by Small Organic Molecules, A New Approach for Cancer Therapy. Ashraf H. Abadi : Up-regulation of the Guardian of the Genome by Small Organic Molecules, A New Approach for Cancer Therapy , 5th International Conference of Scientific Research and Its Applications, 2009. Cairo University, Egypt (Invited speaker).
Conference 2009	Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents Ashraf H. Abadi, Mohammed Abdel-halim, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza : Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents , Dubai International Pharmaceuticals and Technologies (Duphat), 2009. Dubai, UAE

2008

Conference 2008

Shortcuts to the Discovery of New Drugs. Ashraf H. Abadi : Shortcuts to the Discovery of New Drugs , the 1st Conference for the development of the Pharmaceutical Industry and Health Care in Egypt, 2008.
Cairo International Conference Centre, Cairo, Egypt (Invited speaker).

2007

Journal 2007

Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand.Fadi M. Awadallah, Franziska Mueller, Jochen Lehmann, Ashraf H. Abadi, : Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand , Bioorg. Med. Chem. , 2007.
15, 5811-5818

2006

Journal 2006

Synthesis of 3-Substituted-2-Oxoindole Analogues and Their Evaluation as Kinase Inhibitors, Anticancer and Antiangiogenic Agents.Ashraf H. Abadi, Sahar M. Abou-Seri, Doaa E. Abdel-Rahman, Christian Klein, Olivier Lozach, Laurent Meijer : Synthesis of 3-Substituted-2-Oxoindole Analogues and Their Evaluation as Kinase Inhibitors, Anticancer and Antiangiogenic Agents , Eur. J. Med. Chem., 2006.
41, 296-305

Journal 2006

Simultaneous Determination of Indapamide and Captopril in Binary Mixtures by Derivative Spectrophotometry and TLC Densitometry.Bahia A. Moussa, Ashraf H. Abadi, Hanan E. Abou-Youssef and Marianne A. Mahrouse : Simultaneous Determination of Indapamide and Captopril in Binary Mixtures by Derivative Spectrophotometry and TLC Densitometry , Bull. Fac. Pharm. Cairo Univ., 2006.
44, 63-76

2005

Journal 2005	Synthesis of Novel 4-Substituted-7-trifluoromethylquinoline Derivatives With Nitric Oxide Releasing Properties and Their Evaluation As Analgesic and Antiinflammatory Agents.Ashraf H. Abadi, Gehan H. Hegazy, Asmaa A. El-Zaher : Synthesis of Novel 4-Substituted-7-trifluoromethylquinoline Derivatives With Nitric Oxide Releasing Properties and Their Evaluation As Analgesic and Antiinflammatory Agents , Bioorg. Med. Chem., 2005. 13, 5759-5765
Journal 2005	Densitometric Determination of Some Bronchodilators in Inhaler Meterd Aerosols Sonia T. Hassib, Ashraf H. Abadi, Nadia F. Youssef and Hanan A. Ahmed : Densitometric Determination of Some Bronchodilators in Inhaler Meterd Aerosols , Bull. Fac. Pharm. Cairo Univ., 2005. 45, 79-86
Journal 2005	Synthesis and Virtual Screening of novel ß-Carboline Analogues as Potential Phosphodiesterase 5 Inhibitors.Ashraf H. Abadi : Synthesis and Virtual Screening of novel ß-Carboline Analogues as Potential Phosphodiesterase 5 Inhibitors , Bull. Fac. Pharm. Cairo Univ., 2005. 45, 283-289

2004

Journal 2004	Phenylpiperazinylmethylheterocycle Derivatives: Synthesis and Dopamine Receptor Binding Profiles.A. H. Abadi, : Phenylpiperazinylmethylheterocycle Derivatives: Synthesis and Dopamine Receptor Binding Profiles , Arch. Pharm. Pharm. Med. Chem., 2004. 337, 383-390
Journal 2004	Synthesis and Antitubercular Activity of 6-Chloro (Unsubstituted)-2-Methoxy-9-Substituted Acridine Derivatives.Enayat I. Aly, Ashraf H. Abadi, : Synthesis and Antitubercular Activity of 6-Chloro (Unsubstituted)-2-Methoxy-9-Substituted Acridine Derivatives , Arch. Pharm. Res. , 2004. 27, 713-719
Conference 2004	Shortcuts to Blockbuster Drugs. Cairo, Egypt (Invited speaker). : Shortcuts to Blockbuster Drugs , IXXX Conference of the Egyptian Pharmaceutical Society, 2004.

2003

Journal 2003	Synthesis of Novel 1,3,4-Trisubstituted Pyrazole Derivatives and Their Evaluation as Antitumor and Antiangiogenic Agents. Ashraf H. Abadi, Amal A.H. Eissa, Ghaneya S. Hassan, : Synthesis of Novel 1,3,4-Trisubstituted Pyrazole Derivatives and Their Evaluation as Antitumor and Antiangiogenic Agents , Chem. Pharm. Bull. (Tokyo), 2003. 51, 838-844
Journal 2003	Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents. Ashraf H. Abadi, Reto Brun : Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents , Arzneim.-Forsch./Drug Res, 2003. 53, 655-663 2002

2002

Journal 2002

Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist. Ashraf H. Abadi, Stefan Lankow, Barbara Hoefgen, Michael Decker, Matthias U. Kassack, Jochen Lehmann : Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist , Arch. Pharm. Pharm. Med. Chem., 2002. 335, 367-73

2001

Journal 2001

Synthesis and cyclooxygenase inhibitory properties of novel (+) 2-(6-methoxy-2-naphthyl)propanoic acid (naproxene) derivatives. Ashraf H. Abadi, Stefan Laufer, Jochen Lehmann : Synthesis and cyclooxygenase inhibitory properties of novel (+) 2-(6-methoxy-2-naphthyl)propanoic acid (naproxene) derivatives , Arch. Pharm. Pharm. Med. Chem. , 2001.
334, 104-106

2000

Journal 2000	Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist. Ashraf H. Abadi, Stefan Lankow, Barbara Hoefgen, Michael Decker, Matthias U. Kassack, Jochen Lehmann : Dopamine/Serotonin Receptor Ligands, Part III: Synthesis and Biological Activities of 7,7`-Alkylene-bis-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecines-Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist , Arch. Pharm. Pharm. Med. Chem., 2002. 335, 367-73
Journal 2000	The voltammetric study and determination of ramipril in dosage forms and biological fluids. Abulrahma Al-Majed, Ashraf Abadi, Fatthallah Belal, Abelrahman Al-Obaid : The voltammetric study and determination of ramipril in dosage forms and biological fluids , IL Farmaco, 2000. 55, 233-38
Conference 2000	A Traceless Linking Approach to the Solid Phase Synthesis of Novel Potent Dopamine D4 Receptor Ligands. Ashraf H. Abadi, Stefab Loeber, Harlad Huebner, Peter Gmeiner : A Traceless Linking Approach to the Solid Phase Synthesis of Novel Potent Dopamine D4 Receptor Ligands , 10th Oesterreichische Chemietage Conference, 2000. University of Linz, Austria.
Workshop 2000	Molecular Simulation Incorporation (Currently Accelrys). Ashraf H. Abadi : Molecular Simulation Incorporation (Currently Accelrys) , From Gene to Lead: Integrated Drug Discovery, 2000. Frankfurt, Germany November 2000
Conference 2000	NO-NSAIDs. Ashraf H. Abadi, Jochen Lehmann : NO-NSAIDs , International Nitrate Conference, 2000. University of Duesseldorf, Düsseldorf, Germany.

1999

Journal 1999	Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs. Hussein I. El-Subbagh, Ashraf H. Abadi, Ibrahim E. Al- Khawad, Khaled A. Al-Rashood : Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs , Arch. Pharm. Pharm. Med. Chem., 1999. 332, 19-24
Journal 1999	Synthesis, antitumor and antitubercular evaluation of certain new tricyclic planar xanthenones and acridinones. Ashraf H. Abadi, Hussein I. El-Subbagh, Hamd A. Al-Khamees : Synthesis, antitumor and antitubercular evaluation of certain new tricyclic planar xanthenones and acridinones , Arzneim.-Forsch./Drug Res., 1999. 49, 259-66
Journal 1999	2,4-disubstituted-thiazoles III. Synthesis and antitumor activity of ethyl 2-substituted-aminothiazole-4-carboxylate analogs. Hussein I. El-Subbagh, Ashraf H. Abadi, Jochen Lehmann, : 2,4-disubstituted-thiazoles III. Synthesis and antitumor activity of ethyl 2-substituted-aminothiazole-4-carboxylate analogs , Arch. Pharm. Pharm. Med. Chem. , 1999. 332, 137-42
Journal 1999	Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres, as non steroidal cardiotonic agents. Ashraf Abadi, Omar Al-Deeb, Ahmed Al-Afify, Hassan El-Kashef : Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres, as non steroidal cardiotonic agents , IL Farmaco, 1999. 54, 195-201
Journal 1999	Chlorpromazine. Ashraf H. Abadi, Sayed R. Allah, Abdullah A. Al-Badr : Chlorpromazine , Analytical Profile of Drug Substances and Excipients , 1999. 26, 97-165

1998

Journal 1998	New antineoplastic agents with high selectivity towards leukemia cell lines. Ashraf H. Abadi and Hamad A. Al-Khamees, 3-cyano-4,6-disubstituted-2(1H)-imino or oxopyridines : New antineoplastic agents with high selectivity towards leukemia cell lines , Arch. Pharm. Pharm. Med. Chem. , 1998. 331, 319-24
Journal 1998	5-Substituted-2-bromoindolo[3,2-b]quinoxalines. A class of potential antitumor agents with cdc25 phosphatase inhibitory properties.Ashraf H. Abadi : 5-Substituted-2-bromoindolo[3,2-b]quinoxalines. A class of potential antitumor agents with cdc25 phosphatase inhibitory properties , Arch. Pharm. Pharm. Med. Chem., 1998. 331, 352-58

1997

Journal 1997

Synthesis and antitumor activity of 9- anilino, phenylhydrazino and sulphonamido analogs of 2- or 4-methoxy-6-nitroacridines. Hussein I. El-Subbagh, Ashraf H. Abadi, Hamad A. Al-Khamees : Synthesis and antitumor activity of 9- anilino, phenylhydrazino and sulphonamido analogs of 2- or 4-methoxy-6-nitroacridines , Arch. Pharm. Pharm. Med. Chem. , 1997.
330, 277-84

Journal 1997

Synthesis and pharmacological evaluation of some 3-[(4-aryl- and benzylpiperazinyl)alkoxy]-2-methyl -4-(3H)-quinazolinones as potential neuroleptic agents.Ashraf H. Abadi, Hamad A. Al-Khamees, Omar A. Al-Deeb, Mohei M. Elmazar, Abdulrahman M.Ageel : Synthesis and pharmacological evaluation of some 3-[(4-aryl- and benzylpiperazinyl)alkoxy]-2-methyl -4-(3H)-quinazolinones as potential neuroleptic agents , Sci. Pharm., 1997.
65, 113-130

1995

Journal 1995

Spectrophotometric determination of some cardiovascular drugs.Hamed A. Abu-Shady, Sonia T. Hassib, Hassanein H. Hassanein, Ashraf H. Abadi , : Spectrophotometric determination of some cardiovascular drugs , Egypt. J. Pharm. Sci. , 1995.
36, 393-405

1994

Journal 1994	LC determination of celiprolol, diltiazem desmethyldiltiazem and deacetyldiltiazem. David R. Rutledge, Ashraf H. Abadi, Larry M. Lpoez : LC determination of celiprolol, diltiazem desmethyldiltiazem and deacetyldiltiazem , J. Pharm. Biomed. Anal. , 1994.12, 135-40
Journal 1994	Simultaneous determination of verapamil and celiprolol in human plasma. David R. Rutledge, Ashraf H. Abadi, Larry M. Lopez : Simultaneous determination of verapamil and celiprolol in human plasma , J. Chromatogr. Sci. , 1994. 32, 153-56
Journal 1994	Determination of nifedipine and its photodegradation product in pharmaceutical preparation. Hamed A. Abu-Shady, Sonia T. Hassib, Hassanein H. Hassanein, Ashraf H. Abadi : Determination of nifedipine and its photodegradation product in pharmaceutical preparation , Bull. Fac. Ph, . Cairo Univ, 1994. 32, 193-98

1993

Journal 1993

Focus on bisoprolol: A once daily beta-blocker providing 24-hour blood pressure control with balanced renal and hepatic elimination. Stephan M. Steinwandt, Ashraf H. Abadi, David R. Rutledge : Focus on bisoprolol: A once daily beta-blocker providing 24-hour blood pressure control with balanced renal and hepatic elimination , Hosp. Formul., 1993.
28, 453-63

Journal 1993

High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column. David R. Rutledge, Ashraf H. Abadi, Larry M. Lopez, Charles A. Beaudreau : High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column , J. Chromatogr., 1993.
513, 111-16

1992

Workshop 1992	DNA sequencing methodology and PCR techniques course. Ashraf H. Abadi : DNA sequencing methodology and PCR techniques course , The Canter for Advanced Training in Cell and Molecular Biology, 1992. Lake Taho, CA, U.S.A.
Workshop 1992	Basic radiation safety course. Ashraf H. Abadi : Basic radiation safety course , safety course, 1992. University of Florida, FL, U.S.A

Prof. Dr. Darius Zlotos

Email: darius.zlotos@guc.edu.eg
Office:B5-102
Ext: 2196

Biography

Darius P. Zlotos studied chemistry in Bonn, Germany, and received his Ph.D. in Pharmaceutical Chemistry in 1997. After postdoctoral time in Wuerzburg, Germany (1998−2008, “Habilitation” in Pharmaceutical Chemistry in 2004), he was appointed Professor of Pharmaceutical Chemistry at The Germany University in Cairo, Egypt, in 2008. His recent research is focused on the development of subtype-selective and bivalent ligands for melatonin, acetylcholine, and glycine receptors, and hybrid anticancer agents. Dr. Zlotos is a member of the International Union of Basic and Clinical Pharmacology (IUPHAR), subcommittee on Melatonin Receptors, of the German Pharmaceutical Society, and of the German Chemical Society. He is an author/co-author of ca. 50 publications in high-quality journals of organic and medicinal chemistry, and pharmacology. Dr. Zlotos is a reviewer for several journals including the Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, and British Journal of Pharmacology. He has been a member of the selection committee of the German Academic Exchange Service (DAAD, Cairo office) for German Egyptian Master and PhD Research Scholarships since 2009.

Research Interests

1. Subtype-selective and bivalent ligands for melatonin MT1 and MT2 receptors (cooperation with Prof. Paula Witt-Enderby, Duquesne University, School of Pharmacy, Pittsburgh, USA, and Dr. Ralf Jockers, Inserm, Institut Cochin, Paris)
2. Melatonin-tamoxifen hybrids as potential anticancer agents(cooperation with Prof. Paula Witt-Enderby, Duquesne University, Pittsburgh, USA)
3. Strychnos alkaloids as leads for subtype-selective ligands for muscarinic and nicotinic acetylcholine receptors. (cooperation with Prof.. Ulrike Holzgrabe, Pharmaceutical and Medicinal Chemistry, Wuerzburg University, Prof. Klaus Mohr and Dr. Christian Tränkle, Institute for Pharmacology, University of Bonn, Prof.. Anders Jensen, Department of Drug Design and Pharmacology, University of Copenhagen, and Prof. Daniela Gündisch, School of Pharmacy, Hilo University, Hawaii, USA)
4. Ligands for glycine receptors (cooperation with Prof. Anders Jensen, Department of Drug Design and Pharmacology, University of Copenhagen, Prof. Hans-Georg Breitinger, GUC, Prof. Carmen Villmann, Clinical Neurobiology, Wuerzburg University, Prof. Christoph Sotriffer, Pharmaceutical and Medicinal Chemistry, Wuerzburg University)

Publications

2024

Journal 2024

Bedini A, Boutin JA, Legros C, Zlotos DP, Spadoni G. Industrial and academic approaches to the search for alternative melatonin receptor ligands: an historical survey. J. Pineal Res. 2024; 76:e12953. doi:10.1111/jpi.12953

2023

Journal 2023

Helmi YY, Papenkordt N, Rennar G, Gbahou F, El-Hady AK, Labani N, Schmidtkunz K, Boettcher S, Jockers R, Abdel-Halim M, Jung M, Zlotos DP. Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat. Arch Pharm (Weinheim). 2023;356(9):e2300149. doi: 10.1002/ardp.202300149.

2022

Journal 2022	Zlotos DP,* Mandour YM, Jensen AA. Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective. Nat Prod Rep. 2022 Apr 5. doi: 0.1039/d1np00079a, IF (2021) 15.111
Journal 2022	Abdelmalek CM, Hu Z, Kronenberger T, Küblbeck J, Kinnen FJM, Hesse SS, Malik A, Kudolo M, Niess R, Gehringer M, Zender L, Witt-Enderby PA, Zlotos DP, * Laufer SA. * Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer. J Med Chem. 2022, 65(6), 4616-4632. doi: 10.1021/acs.jmedchem.1c01646, IF (2021) 8.039

2021

Journal 2021	Zlotos, D. P.;* Abdelmalek, C.; Botros, L.; Banoub, M.; Mandour, Y.; Breitinger, U.; Breitinger, H-G; El Nady, A.; Sotriffer, C.; Villmann , C. ; Jensen, A.; Holzgrabe, U. C-2 Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. Journal of Natural Products, 2021, 84, 2, 382–394, https://doi.org/10.1021/acs.jnatprod.0c01030
Journal 2021	El-Zohairy MA, Zlotos DP, Berger MR, Adwan HH, Mandour YM. Discovery of Novel CCR5 Ligands as Anticolorectal Cancer Agents by Sequential Virtual Screening, ACS Omega 2021, 6, 16, 10921–10935, https://doi.org/10.1021/acsomega.1c00681
Journal 2021	Malka MM, Eberle J, Niedermayer K, Zlotos DP, Wiesmüller L.Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells. Biomolecules, 2021, 11(7), 981, https://doi.org/10.3390/biom11070981

2020

Journal 2020	Boutin JA, Witt-Enderby PA, Sotriffer C, Zlotos DP. (2020) “Melatonin Receptor Ligands: A Pharmaco-Chemical Perspective” J. Pineal. Res. 2020;00:e12672. IF (2019) 14.528
Journal 2020	Mandour YM, Zlotos DP, Salem MA (2020)“A multi-stage virtual screening of FDA-approved drugs reveals potential inhibitors of SARS-CoV-2 main protease”, Journal of Biomolecular Structure and Dynamics, 2020, DOI: 10.1080/07391102.2020.1837680
Grant 2020	“Hybrid Ligands of Diverse Kinase Inhibitors and Tamoxifen as Dually Acting Agents against Breast Cancer 2021” Cooperation with Tuebingen University on Anti-Cancer Drug Conjugates. (2020) visit event

2019

Journal 2019

Zlotos DP,* Mohsen AMY, Mandour YM, Marzouk MA, Breitinger U, Villmann C, Breitinger HG, Sotriffer C, Jensen AA, Holzgrabe U; 11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors..Journal of Natural Products. 2019, 82(8), 2332-2336. doi:10.1021/acs.jnatprod.9b00180.

Journal 2019

Hasan M, Marzouk MA, Adhikari S, Wright TD, Miller BP, Matossian MD, Elliott S, Wright M, Alzoubi M, Collins-Burow BM, Burow ME, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA.; Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs.Molecular Pharmacology. 2019, 96(2), 272-296. doi: 10.1124/mol.119.11620.

Journal 2019

Hasan M, Wright TD, Adhikari S, Marzouk MA, Pericoloso A, Murgas K, Burgman M, Miller BP, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA; Melatonin-tamoxifen drug conjugates: Mechanism against breast cancer cells, and pharmacokinetic assessment in female mice. Cancer Research 2019, 79 (13 Supplement), 3893-3893, doi: 10.1158/1538-7445.AM2019-3893. Poster presented at the AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, USA

Journal 2019

Karamitri, A.; Sadek, M.S.; Journé, A-S.; Gbahou, F.; Gerbier, R.; Osman, M.B.; Habib, S.A.M; Jockers, R.; Zlotos, D.P.; O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors. Bioorganic Chemistry, 2019, 85, 349-356.

2018

Journal 2018	Hasan, M.;Marzouk, M.A., Adhikari, S.; Wright, T.; Miller, B., Peckich, B.; Yingling, S.; Stratford, R.; Zlotos, D.P.; Cavanaugh, J.; Witt-Enderby, P.A.Melatonin-tamoxifen hybrid ligands and their effects on breast cancer. Cancer Research, 2018, 78 (13 Supplement), 3915-3915.
Journal 2018	Mandour, Y. M.;* Breitinger, U.; Ma, C.; Wang, J.; Boeckler, F. M.; Breitinger, H-G.; Zlotos, D. P. Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis c virus p7. Drug Design, Development and Therapy, 2018, 12, 1019-1031.

2017

Journal 2017	Riad, N. M.; Zlotos, D. P.;Holzgrabe, U. 2-Amino-N-(2-chloropyridin-3 yl) benzamide*. IUCrData, 2017, 2 (10), x171536.
Journal 2017	Riad, N. M.; Zlotos, D. P.;*Holzgrabe, U.3-(2-Chloropyridin-3-yl) quinazoline-2, 4 (1H, 3H)-dione chloroform monosolvate. IUCrData, 2017, 2 (4), x170580.

2016

Journal 2016	Jockers, R.;* Delagrange, P.; Dubocovich, M.L.; Markus, R.P.; Renault, N.; Tosini, G.; Cecon, E.; Zlotos, D.P. Update on melatonin receptors: IUPHAR Review 20. Br. J. Pharmacol., 2016, 173, 2702-2725.
Journal 2016	Mohsen, A.M.; Mandour, Y.M.; Sarukhanyan, E.; Breitinger, U.; Villmann, C.: Banoub, M.M.; Breitinger, H.G.; Dandekar, T.; Holzgrabe, U.; Sotriffer, C.; Jensen A.A.; Zlotos D.P. *Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists. J. Nat. Prod., 2016, 79, 2997-3005.
Journal 2016	Darwish, H.W.; Attia, M.I.;* Zlotos, D.P. New spectrofluorimetric methods for determination of melatonin in the presence of N-{2-[1-({3-[2-(acetylamino) ethyl]-5-methoxy-1H-indol-2-yl}methyl)-5-methoxy-1H-indol-3-yl]-ethyl}acetamide: a contaminant in commercial melatonin preparations. Chem. Central J., 2016, 10:57. Erratum to: Darwish, H.W.; Attia, M.I. Chem. Central J., 2012, 6:36 (in the original publication my name was omitted in the list of the authors)

2015

Journal 2015	Behnam, M.A.; Graf, D.; Bartenschlager, R.; Zlotos, D.P.; Klein, C.D.* Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue. J. Med. Chem., 2015; 58, 9354-9370.
Journal 2015	Riad, N.M.; Zlotos, D.P.;* Holzgrabe U. Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one. Acta Cryst., 2015, E71, o304-0305.
Journal 2015	Riad, N.M.; Zlotos, D.P.;* Holzgrabe U. Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one. Acta Cryst., 2015, E71, o304-0305.
Journal 2015	Zlotos, D.P.;* Riad, N.; Osman, M.B.; Dodda, B.R.; Witt-Enderby, P.A. Novel Difluoroacetamide Analogues of Agomelatine and Melatonin: Probing the Melatonin Receptors for MT1-Selectivity. Med. Chem. Commun., 2015, 6, 1340-1344.

2014

Journal 2014	Zlotos, D.P;* Jockers, R.; Cecon, E.; Rivara, S.; Witt-Enderby, P.A. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J. Med. Chem., 2014, 57, 3161-3185.
Journal 2014	Zlotos, D.P. Development of Agonists and Antagonists for Melatonin Receptors In Melatonin and Melatonergic Drugs in Clinical Practice, V. Srinivasan et al. (eds) , pp 97-116, Springer India, 2014
Journal 2014	Zlotos, D.P.;* Tränkle, C.; Holzgrabe, U.; Gündisch, D.; Jensen, A.A. Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors. J. Nat. Prod. 2014, 77, 2006-2013.
Journal 2014	Journe, A-S.; Habib, S.A.M.; Dodda, B.R.; Morcos, M.N.F.; Sadek, M.S.; Tadros, S.A.A., Witt-Enderby, P.A.; Jockers, R.; Zlotos, D.P. * N1-Linked Melatonin Dimers as Bivalent Ligands Targeting Dimeric Melatonin Receptors. Med. Chem. Commun., 2014, 5, 792-796.
Journal 2014	Mohsen, A.M.; Heller, E.; Holzgrabe, U.; Jensen, A.A, Zlotos D.P. *Structure-activity relationships of strychnine analogs at glycine receptors . Chem Biodivers., 2014, 11, 1256-1262.

2013

Journal 2013

Heller, E.; Gutmann, A.; Hiltensperger, G.; Lautenschläger, W.; Lohse, M.J.; Schad, C.; Schirmeister, T.; Seufert, F.; Zlotos, D.P.; Holzgrabe, U. Microwave Hydrogenations: Large-Size, High-Pressure Microwave Reactor. G.I.T Laboratory Journal, 2013, 1-2, 32-33.

2012

Journal 2012

Zlotos, D.P. Recent progress in the development of agonists and antagonists for melatonin receptors. Curr. Med. Chem., 2012, 9, 3532-3549.

2011

Journal 2011	Heckman, D.; Attia, M. I.; Behnam, M. A. M.; Mohsen, A. M. Y.; Markl, C.; Julius, J.; Sethi, Sethi, S.; Witt-Enderby, P. A.; Zlotos, D. P. *2-[(1,3-Dihydro-2H-isoindol-2yl)methyl]melatonin – a novel MT2-selective melatonin receptor antagonist. Med. Chem. Comm., 2011, 2, 991-994.
Journal 2011	Markl, C.; Clafshenkel, W. P.; Attia, M. I.; Sethi, S.; Witt-Enderby, P. A.; Zlotos, D. P.. N-Acetyl-5-arylalkoxytryptamine Analogs: Probing the Melatonin Receptors for MT1-Selectivity. Arch. Pharm. (Weinheim), 2011, 344, 666-674.
Journal 2011	Markl, C; Zlotos, D.P.* Novel Synthesis of the Antidepresssant Agomelatine. Synthesis, 2011, 1, 79-82.
Journal 2011	Sripha, K.; * Zlotos, D.P.; Hplygrabe, U.; Ruchirawat, S. A new synthetic approach to a pentacyclic ring, 6,7,14,15-Tetrahydro[1,5]dizocino[1,2-a;6,5-a’]dihydroindole. Heterocycles, 2011, 83, 2627-2633.

2009

Journal 2009	Zlotos, D. P.*.; Attia, M. I.; Julius, J.; Shalini, S.; Witt-Enderby, P. A.. 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin Analogs: A novel class of MT2-Selective Melatonin Receptor Antagonists. J. Med. Chem., 2009, 52, 826-833.
Journal 2009	Markl, C.; Attia, M. I.; Julius, J.; Witt-Enderby, P. A.; Zlotos, D. P.*. Synthesis and pharmacological evaluation of 1,2,3,4-Tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as melatoninergic ligands. Bioorg. Med. Chem., 2009, 17, 4583-4594.

2008

Journal 2008

Seufert, S.; Coras, R.; Tränkle, C.;.Zlotos, D.P.; Blümcke, I.; Tatenhorst, L.; Heneka, M.T.; Hahnen, E.* PPAR gamma activators: Off-target against glioma cell migration and brain invasion. PPAR Research, 2008, Article ID 513943, 7 pages, doi: 10.1155/2008/513943.

2007

Journal 2007	Zlotos, D.P. Is there a better way on the horizon to treat sleeplessness ? Effective substances in the pipeline.Pharmazie in unserer Zeit, 2007, 36, 218-220.
Journal 2007	Jensen, A.A.; Zlotos, D. P.; Liljefors, T. Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal ï¡7 acetylcholine receptor*. J. Med. Chem. 2007, 50, 4616-4629.
Journal 2007	Attia, M. I.; Güclü, D.; Hertlein, B.; Julius, J.; Witt-Enderby, P. A.; Zlotos, D. P.* Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a´]diindole analogues as melatonin receptor ligands. Org. Biomol. Chem., 2007, 5, 2129-2137.
Journal 2007	Attia, M. I.; Julius, J.; Witt-Enderby , P. A.; Zlotos, D. P.*Synthesis and pharmacological evaluation of 13a,14-dihydro-6H, 13H-pyrazino- [1,2-a;4,5-a´]diindole analogs as melatonin receptor ligands. Tetrahedron, 2007, 63, 754-760.

2006

Journal 2006	Jensen, A. A.; Gharagozloo, P.; Birdsall, N. J. M.; Zlotos, D. P. Pharmacological characterisation of strychnine and brucine analogues at glycine and ï¡7 nicotinic acetylcholine receptors*. Eur. J. Pharmacol., 2006, 539, 27-33.
Journal 2006	Zlotos, D. P.*; Tränkle, C.; Abdelrahman, A.; Gündisch, D.; Radacki, K.; Braunschweig, H.; Mohr, K.. 6H,13H-Pyrazino[1,2-a;4,5-a´]diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors. Bioorg. Med. Chem. Lett. 2006, 16, 1481-1485.

2005

Journal 2005	Zlotos, D. P. Recent advances in neuromuscular blocking agents. Mini Reviews in Med. Chem., 2005, 5, 595-606.
Journal 2005	Zlotos, D. P. Recent advances in melatonin receptor ligands Arch. Pharm. (Weinheim), 2005, 338, 229-247.

2004

Journal 2004	Zlotos, D. P.; Gündisch, D.; Ferraro, S.; Tilotta, B.; Stiefl, N.; Baumann, K. Bisquaternary caracurine V and iso-caracurine V as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies*. Bioorg. Med. Chem. 2004, 12, 6277-6285.
Journal 2004	Zlotos, D. P. Stereochemistry of caracurine V, iso-caracurine V, bisnortoxiferine and tetrahydrocaracurine V ring systems. Eur. J. Org. Chem. 2004, 11, 2375-2380.
Journal 2004	Zlotos, D. P.; Buller, S.; Stiefl, N.; Baumann, K.; Mohr, K. Probing the pharmacophore for allosteric ligands of muscarinic M2 receptors: SAR and QSAR studies in a series of bisquaternary salts of caracurine V and related ring systems* J. Med. Chem. 2004, 47, 3561-3571.

2003

Journal 2003	Sripha, K.; Zlotos, D. P.; Buller, S.; Mohr, K. 6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-bï‚¢]diindole. Synthesis of a novel pentacyclic ring system.* Tetrahedron Lett. 2003, 44, 7183-7186.
Journal 2003	Zlotos, D.P. Iso-Caracurine V: a Novel Unexpected Decomposition Product of Caracurine V J. Nat. Prod., 2003, 66, 119-120.
Journal 2003	Zlotos, D. P.; Buller, S.; Holzgrabe, U.; Mohr, K. Bisquaternary Dimers of Strychnine and Brucine. A New Class of Potent Enhancers of Antagonist Binding to Muscarinic M2 Receptors.* Bioorg. Med. Chem., 2003 , 11, 2627-2634.

2002

Journal 2002	Cambareri, A.; Zlotos, D. P.; Holzgrabe, U.; Englberger, W.; Haurand, M. Stereochemistry and Opioid Receptor Affinity of 2,4-Dipyridine-3,7-diazabicyclo[3.3.1]-nonanones - Influence of the Substituent in Position N7 J. Heterocyc. Chem., 2002, 39(4), 789-798.
Journal 2002	Buller, S.; Zlotos, D. P.; Mohr, K.; Ellis J.* Allosteric Site on Muscarinic Acetylcholine Receptors: a Single Amino Acid in TM7 Is Critical to the Subtype Selectivities of Caracurine V Derivatives and Alkane-bisammonium Ligands. Mol. Pharmacol., 2002, 61, 160-168.

2000

Journal 2000	Zlotos, D. P.; Buller, S.; Tränkle, C.; Mohr, K. Bisquaternary Caracurine V Derivatives as Allosteric Modulators of Ligand Binding to M2 Acetylcholine Receptors*. Bioorg. Med. Chem. Lett., 2000, 10(22), 2529-2532.
Journal 2000	Zlotos, D. P. Stereochemistry of Caracurine V. J. Nat. Prod., 2000, 63(6), 864-865.

1999

Journal 1999

Nassif-Makki,T.; Tränkle, C.; Zlotos, D.P.; Bejeuhr, G.; Cambareri, A.; Pfletschinger, C.; Kostenis, E.; Mohr, K.; Holzgrabe, U.* Bisquaternary Ligands of the Common Allosteric Site of M2 Acetylcholine Receptors: Search for the Minimum Essential Distances Between the Pharmacophoric Elements. J. Med. Chem. 1999, 42, 849-858.

1997

Journal 1997

Zlotos, D. P.*; Meise W.. Synthesis and Conformational Analysis of Hexahydroisoquino-[3,2-b][3]benzazepines (iso-B-Homoberbines). Heterocycles, 1997,45, 2137-2157.

1995

Journal 1995

Meise, W.*; Zlotos, D. P.; Jansen, M.; Zoche, N. Synthese und Konformation von Hexahydroisochino[3,2-a][2]benzazepinen des B-Homoberbin-Typs. Liebigs Ann. Chem. 1995, 567-574.

1994

Journal 1994

Meise, W.*; Arth, Ch.; Zlotos, D. P.; Jansen, M.; Feldmann, C. Aufbau und Konformation der Hexahydroisochino[2,1-b][2]benzazepine. Liebigs Ann. Chem. 1994, 1135-1142.

Prof. Dr. Rasha Hanafi

Email: rasha.hanafi@guc.edu.eg
Office:B5-103
Ext: 3405

Biography

Rasha Hanafi is Professor of Pharmaceutical Analysis and Vice Dean of Student Affairs at the Faculty of Pharmacy and Biotechnology of the German University in Cairo.

She is an Alexander von Humboldt alumna, DAAD alumna and Research Affiliate at the Eberhard-Karls-University Tübingen, Institute of Pharmaceutical Sciences Pharmaceutical (Bio-) Analysis as well as a member of the Research Alumni Network of the University of Tübingen.

She is a highly experienced and dedicated teacher and supervised more than 40 masters and PhD theses of national and international students. She published ca. 50 articles in peer reviewed international journals and 30 conference abstracts (posters and oral presentations). In addition, she is reviewer and editor of international peer reviewed journals and, moreover, reviewer of national grants.

Her main research field is Pharmaceutical and Bio-Analysis including Metabolomics and Quality by Design in analytical methods with focus on the incorporation of suitable computational concepts, in order to reduce the number of experiments and, hence, the consumption of chemicals.

Her research includes activities related to DoE in chiral separations (including in vitro- and in-vivo-decomposition products, in-vivo kinetic studies, discovery of novel human biomarkers and novel compounds of phytochemical origin and with promising pharmacological actions.

She serves as scientific consultant and free-lance trainer for pharmaceutical/chemical companies and in academia in the field of rational Design-of-Experiments-guided analytical method development with focus on the various aspects of sustainability in chromatography, on Quality Control and Assurance.

Her research collaborations in Germany include groups from the University of Tübingen, the Freie University of Berlin, the University of Braunschweig, and the University of Mainz.

http://orcid.org/0000-0002-8196-5108

http://scholar.google.com.eg/citations?user=QzorriwAAAAJ&hl=en

http://www.researchgate.net/profile/Rasha-Hanafi-2

Research Interests

Pharmaceutical and bioanalysis using hyphenated mass spectrometric chromatographic systems.
Targeted and untargeted metabolomics, targeted proteomics,
Quality-by-Design in analytical methods using Design-of-Experiments and multivariate analysis.
Response surface methodology for determination of chiral recognition on HPLC separations.
Drug-drug interaction in vivo and in vitro studies
New prodrugs for improved drug delivery in vivo.

Publications

2024

Journal 2024	Farag, Y.G., Hanafi, R.S.* & Hammam, M.A. Novel dummy molecularly imprinted polymer for simultaneous solid-phase extraction of stanozolol metabolites from urine. Analytical and Bioanalytical Chemistry 2024. https://doi.org/10.1007/s00216-024-05285-x
Journal 2024	Yasmin Elshoura, Magy Herz, Mohamed Z. Gad, Rasha Hanafi. A comprehensive review on analytical methods and levels in health and disease, Analytical Biochemistry*, 694,115624 (2024). https://doi.org/10.1016/j.ab.2024.115624

2023

Journal 2023	Herz, M.M.; Gad, M.Z.; Hanafi, R.S. Development and Validation of a Bioanalytical Method for the Quantification of Nitrated Fatty Acids in Plasma Using LC-MS/MS: Application to Cardiovascular Patients. Separations 2023, 10, 87. https://doi.org/10.3390/separations10020087
Journal 2023	Noha H. Atta, Heba Handoussa, Iris Klaiber, Bernd Hitzmann, Rasha S. Hanafi. "Chemometric Approach for Profiling of Metabolites of Potential Antioxidant Activity in Apiaceae Species Based on LC-PDA-ESI-MS/MS and FT-NIR". Separations 2023, 10, 347. https://doi.org/10.3390/separations10060347
Conference 2023	Development and Validation of a Bioanalytical Method for Quantification of Nitrated Fatty Acids in Plasma of Cardiovascular Patients by LC-MS/MS. M. Herz, M. Gad, R. Hanafi. HPLC2023, 51st international symposium on High Performance Liquid Chromatography and related techniques, June 2023, Düsseldorf, Germany. Supported by the Alexander von Humboldt foundation.
Journal 2023	Adel Ehab Ibrahim#, Nesrine Abdelrehim El Gohary#, Dina Aboushady, Liza Samir, Shereen Ekram Abdel Karim, Magy Herz, Baher I. Salman, Ahmed Al-Harrasi, Rasha Hanafi, Sami El Deeb. "Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review.* " Journal of Chromatography A. Volume 1706, 13 September 2023, 464214. https://doi.org/10.1016/j.chroma.2023.464214.
Journal 2023	Ammar, Mai.K., Hanafi, Rasha.S., Choucry, Mouchira.A. Heba Handoussa "Structural, functional, nutritional composition and analytical profiling of Triticum aestivum L." Applied Biological Chemistry 2023, 66, 48. https://doi.org/10.1186/s13765-023-00804-3.
Journal 2023	"Determination of Capecitabine and its Metabolites in Plasma of Egyptian Colorectal Cancer Patients". Shamseldin, S.; Botros, L.S.; Salem, S.E.; Abdel-Maksoud, S.; Gad, M.Z.; Hanafi, R.S. Analytica* 2023, 4, 397–414. https://doi.org/10.3390/analytica4040029

2022

Journal 2022	Quality-by-design approach for development of aqueous headspace microextraction GC-MS method for targeted metabolomics of small aldehydes in plasma of cardiovascular patients. Rasha S. Hanafi; Michael Lämmerhofer. Analytica Chimica Acta, Volume 1221, 2022, 340176, https://doi.org/10.1016/j.aca.2022.340176
Journal 2022	Aya A Ezzat; Salma N Tammam; Rasha S Hanafi; Omar Rashad; Aya Osama; Eman Abdelnaby; Sameh Magdeldin; Samar Mansour. “Different Serum, Different Protein Corona! The Impact of the Serum Source on Cellular Targeting of Folic Acid-Modified Chitosan-Based Nanoparticles”. Molecular pharmaceutics 2022, https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00108
Journal 2022	Quality by design approach for enantioseparation of terbutaline and its sulfate conjugate metabolite for bioanalytical application using supercritical fluid chromatography, Dina Aboushady, Rasha S. Hanafi, Maria K. Parr Journal of Chromatography A, Volume 1676, 2 August 2022, https://doi.org/10.1016/j.chroma.2022.463285
Journal 2022	Liza Samir; Rasha Hanafi; Sami El Deeb; Hilde Spahn-Langguth.UHPLC Enantiomer Resolution for the α/β-Adrenoceptor Antagonist R/S-Carvedilol and Its Major Active Metabolites on Chiralpak IB N-5. Molecules 2022, 27, 4998 (Special Issue: Advances in Chiral Separations) https:// doi.org/10.3390/molecules27154998

2021

Journal 2021	Chiral Capillary Electrokinetic Chromatography: Principle and Applications, Detection and Identification, Design of Experiment, and Exploration of Chiral Recognition Using Molecular Modeling. El Deeb, S.; Silva, C.F.; Junior, C.S.N.; Hanafi, R.S.; Borges, K.B. Molecules, , 26, 2841. https://doi.org/10.3390/molecules26102841.
Journal 2021	Spectrophotometric and Spectrofluorometric determinations of Lomefloxacin lanthanum complex in tablets using multivariate modeling and optimization stratagem. Marwa El Hamshary; Rasha S Hanafi; Marwa A Fouad; Hala S Al-Easa; Samir M El-Moghazy. Journal of the Iranian Chemical Society, https://doi.org/10.1007/s13738-021-02162-7.
Journal 2021	An intronic DHCR7 genetic polymorphism associates with vitamin D serum level and incidence of acute coronary syndrome. Mariam M. Elbehairy, Hala Y. Abdelnasser, Rasha S. Hanafi, Sally I. Hassanein, Mohamed Z. Gad. Steroids, https://doi.org/10.1016/j.steroids.2021.108825.
Journal 2021	Novel UPLC-MS/MS method for standardization of niazimicin content in edible seeds and leaves of Moringa oleifera Lam. Eman M Abdelsayed, Amira Abdel Motaal, Rasha S. Hanafi, Journal of Food and Drug Analysis*, 29(1), 10. https://doi.org/10.38212/2224-6614.3282
Journal 2021	Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction. Mufarreh Asmari, Xiaoyu Wang, Natalia Casado, Marjan Piponski, Sergiy Kovalenko, Liliya Logoyda, Rasha Sayed Hanafi, Sami El Deeb. Molecules, 2021, 26 (17), 5241.https://doi.org/10.3390/molecules26175241
Journal 2021	Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity. Eman M. Abdelsayed, Dalia Medhat, Yasmine M. Mandour, Rasha S. Hanafi, Amira Abdel Motaal. Journal of Food Biochemistry, https://doi.org/10.1111/jfbc.13992

2020

Journal 2020	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities. Mai K. Ammar; Heba Handoussa; Rasha S. Hanafi; Mohamed El-Shazly; Mohamed Z. Gad. Natural Product Research, https://doi.org/10.1080/14786419.2020.1837817
Journal 2020	Quality-by-Design is a Tool for Quality Assurance in the Assessment of Enantioseparation of a Model Active Pharmaceutical Ingredient. Dina Aboushady, Maria Kristina Parr, Rasha S. Hanaﬁ. Pharmaceuticals, Special Issue Analytical Techniques in the Pharmaceutical Sciences, Volume 13, Issue 11, DOI: 10.3390/ph13110364
Journal 2020	Resistance of Biomphalaria alexandrina to Schistosoma mansoni and Bulinus truncatus to Schistosoma haematobium correlates with unsaturated fatty acid levels in the snail soft tissue. Marian Elias, Rasha S. Hanafi, Samia El-Bardicy, Ebtisam A. Hafez, Rashika El Ridi. Journal of Parasitology Research, Volume 2020, DOI:10.1155/2020/8852243
Journal 2020	Response surface methodology for spectrophotometric determination of two β-adrenergic agonists-terbium chemosensors in urine and pharmaceutical dosage forms. Marwa Sakr, Marwa Fouad, Rasha Hanafi, Hala Al-Easa, Samir El-Moghazy. Journal of AOAC INTERNATIONAL, qsaa131, https://doi.org/10.1093/jaoacint/qsaa131
Journal 2020	The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study. Elsabbagh, R. A., M. F. A. Rahman, S. I. Hassanein, R. S. Hanafi, R. A. Assal, G. M. Shaban, and M. Z. Gad. Journal of Advanced Research, 21: 49-56.

2019

Journal 2019	Screening and optimization of samarium-assisted complexation for the determination of Norfloxacin, Levofloxacin and Lomefloxacin in their corresponding dosage forms employing spectrofluorimetry. Marwa El Hamshary, Marwa A Fouad ; Rasha S Hanafi ; Hala S Al-Easa ; Samir M El-Moghazy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 206 (2019) 578–587.
Journal 2019	Point-of-care testing and optimization of sample treatment for fluorometric determination of Hydrogen Sulphide in plasma of cardiovascular patients.Ahmed K. Alyan, Rasha Hanafi, Mohamed Z. Gad. Journal of Advanced Research*, DOI: 10.1016/j.jare.2019.11.010.
Conference 2019	Exploring the design space for enantiomeric resolution of terbutaline drug and its sulfate conjugate metabolites using design of experiment approach. D. abou-shady, R.S. Hanafi, M.K. Parr. 48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, University of Milano-Bicocca, Milan, Italy, Poster 424.
Journal 2019	Contribution of CYP27B1 and CYP24A1 genetic variations to the incidence of acute coronary syndrome and to vitamin D serum level. Fam, M. S., S. I. Hassanein, M. F. A. Rahman, R. A. Assal, R. S. Hanafi, and M. Z. Gad. Canadian Journal of Physiology and Pharmacology, 97: 1152-58.
Journal 2019	Surface Design of Enantiomeric HPLC Separation on Vancomycin and Teicoplanin-Based Stationary Phases, a Tool for Chiral Recognition of Model beta-Blockers. George, N., M. Herz, H. Y. Aboul-Enein, L. Shihata, and R. Hanafi. Journal of Chromatographic Science, 57: 485-94.
Journal 2019	Design and optimization of a luminescent Samarium complex of isoprenaline: A chemometric approach based on Factorial design and Box-Behnken response surface methodology.Sakr, M., R. Hanafi, M. Fouad, H. Al-Easa, and S. El-Moghazy. 2019., Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 208: 114-23.

2018

Journal 2018	Response Surface Methodology for the Determination of the Design Space of Enantiomeric Separations on Cinchona-based Zwitterionic Chiral Stationary Phases by High Performance Liquid chromatography. Rasha Sayed Hanafi, Michael Lämmerhofer, Journal of Chromatography A.*,1534, 55-63.
Journal 2018	A chiral enantioseparation generic strategy for anti-Alzheimer and antifungal drugs by short end injection capillary electrophoresis using an experimental design approach. Chirality. Ahmed Abdelmegied, Rasha S. Hanafi, Hassan Y. Aboul-Enein.2018 Feb;30(2):165-17
Conference 2018	Point of Care Testing of Hydrogen Sulphide in Patients with Cardiovascular Diseases. Ahmed Khaled Raafat, Rasha Sayed Hanafi, Mohamed Zakaria Gad.The international conference of Biochemistry and Molecular Biology, March 24th-25th 2018, German University in Cairo, Egypt. 1st Prize poster.
Conference 2018	Contribution of CYP27B1 and CYP24A1 Genetic Variation in the Incidence of Acute Coronary Syndrome and Serum Level of 25-Hydroxy vitamin D. Marina Sherif Fam, Sally I. Hassanein, Mohamed Farouk, Reem Asal, Rasha S. Hanafi, Mohamed Z. Gad. The international conference of Biochemistry and Molecular Biology, March 24th-25th, German University in Cairo, Egypt.
Conference 2018	Determination of the Design Spaces of Chiral Separations of β-Blockers. Nadine George, Hassan Aboul-Enein, Lamia Shihata, Rasha Hanafi. ISC 2018, 32nd International Symposium on Chromatography, Abstract PS-05-12, 23-27, Cannes- Mandelieu, France.
Conference 2018	Quality by Design Approach for HPLC Method development on Vancomycin Based Stationary Phase. Magy M. Herz, Rasha S. Hanafi, Lamia A. Shehata, Hassan Y. Aboul-Enein. ISC 2018, 32nd International Symposium on Chromatography, Abstract PS-05-13, 23-27, Cannes- Mandelieu, France.

2017

Journal 2017	Method Development Using DryLab® for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-qTOF-MSn. Heba Handoussa, Rasha Hanafi, Ahmed El-Khatib, Michael Linscheid, Laila Mahran and Nahla Ayoub; Journal of Botanical Sciences 6 (1): 9-16.
Journal 2017	HPLC Determination of the Levels of 6-Mercaptopurine Metabolites Suitable for the Clinical Risk Assessment of its Toxicity among Egyptian Children with Acute Lymphocytic Leukemia.Eman Abdelsayed, Sahar Maksoud, Iman Sidhom, Mohamed Gad, Rasha Hanafi, Journal of Analytical & Bioanalytical Techniques. 8:2 DOI: 10.4172/2155-9872.1000358
Book 2017	Determination of Mercaptopurine metabolites and toxicity in children. Rasha Hanafi, Iman Sidhom, Eman Abdel-Sayed, Sahar Abdel-Maksoud, Mohamed Gad : Determination of Mercaptopurine metabolites and toxicity in children , Scholars' Press, 2017. ISBN-10: 6202300094 ISBN-13: 978-6202300094
Conference 2017	Determination of Capecitabine and its metabolites in plasma of Egyptian colorectal cancer patients. S. shams, S. Abdel-Maksoud, s. Eid, m. Gad, R. Hanafi. Oral presentation in Analytical and Bioanalytical Techniques, Brussels, Belgium. Certificate of recognition for the “phenomenal and worthy oral presentation”

2016

Journal 2016	A Comparative Metabolomics Approach Reveals Early Biomarkers for Metabolic Response to Acute Myocardial Infarction. Sara Ali, Mohamed Farag, Paul Holvoet, Rasha Sayed Hanafi, Mohamed Zakaria Gad. Scientifc Reports, Nature. 6: 36359. doi:10.1038/srep36359
Journal 2016	miR-29a Promotes Lipid Droplet and Triglyceride Formation in HCV Infection by Inducing Expression of SREBP-1c and CAV1. Mahdy MM, El-Ekiaby NM, Hashish RM, Salah RA, Hanafi RS, El-Said Azzazy HM, Abdelaziz AI. Journal of Clinical and Transnational Hepatology, 4(4):293-299.
Conference 2016	Early elevation of H2S in serum of ST segment Elevation Myocardial infarction (STEMI) patients. Mohamed Z. Gad, Sara E. Ali, Mohamed A. Farag, Rasha S. Hanafi. 16th IUBMB conference “Signaling Pathways in development, disease and aging”, Vancouver, BC, Canada.

2015

Conference 2015	HPLC Determination of the Levels of 6-MP Metabolites and its Relation to Risk of Drug Toxicity among Egyptian Children with Acute Lymphocytic Leukemia. Eman Abdelsayed, Sahar Abdelmaksoud, Iman Sidhom, Mohamed Gad, Rasha Hanafi. HPLC2015, 42nd international symposium on high performance liquid phase separations and related techniques, Geneva, Switzerland.
Conference 2015	Design-of-Experiment Approach for Determination of Fat soluble Vitamins on Core-Shell Technology Stationary Phase by HPLC. Norhan Elgizawy, Rasha Hanafi, HPLC2015, 42nd international symposium on high performance liquid phase separations and related techniques, Geneva, Switzerland.
Conference 2015	Controlling hepatocyte lipid droplet proteins through regulation of SREBP-1c and caveolin-2 by miR-29a in HCV infected cell models. Mennatallah M. Mahdy · Nada El-Ekiaby · Noha M. Elemam · Shereen A. ElSobky · Rasha Hanafi · Ahmed I. Abdelaziz, Monothematic Conference: 'Microbiota, Metabolism and NAFLD, Innsbruck, Austria.
Journal 2015	Structural docking studies of COX-II inhibitory activity for metabolites derived from Corchorus olitorius and Vitis vinifera. Yasmine Mandour · Heba Handoussa · Noha Swilam · Rasha Hanafi · Laila Mahran. International Journal of Food Properties, 19:2377–2384.
Conference 2015	Controlling hepatocyte lipid droplet proteins through regulation of SREBP-1C and Caveolin-2 by MIR-29A in HCV infected cell models.Mennatallah Mahdy, Nada Elekiaby, Noha Elemam, Shereen Elsobky, Rasha Hanafi, Ahmed Abdelaziz. European Association for the study of the liver, monothematic conference, Microbiota, Metabolism and NAFLD, Austria.
Conference 2015	Design-of-Experiment Approach for Determination of Fat soluble Vitamins on Core-Shell Technology Stationary Phase by HPLC. Norhan Elgizawy, Rasha Hanafi.42nd symposium on High performance liquid phase separations and related techniques, HPLC2015, Genève, Switzerland.
Conference 2015	HPLC Determination of the Levels of 6-MP Metabolites and its Relation to Risk of Drug Toxicity among Egyptian Children with Acute Lymphocytic Leukemia. Eman Abdelsayed, Sahar Abdelmaksoud, Iman Sidhom, Mohamed Gad, Rasha Hanafi. 42nd symposium on High performance liquid phase separations and related techniques, “HPLC2015”, Genève, Switzerland.
Conference 2015	A Comparative Metabolomic Approach (COMET) Reveals Early Biomarkers for Metabolic Response to Acute Myocardial Infarction. Sara Ezz, Mohamed Farag, Rasha Hanafi, Mohamed Gad. Conference of Heliopolis University, Egypt.

2014

Journal 2014	Enantiomeric Separation of underivatized amino acids: Predictability of chiral recognition on Ristocetin A chiral stationary phase Hebattallah Wagdy, Rasha Hanafi. Rasha Elnashar, Hassan Abiulenein, Chirality. 26:132-135
Journal 2014	Design-of-Experiment Approach for HPLC Analysis of25-Hydroxy Vitamin D. A Comparative Assay with ELISA. Mohamed Abdulla Abu el Maaty, Rasha Sayed Hanafi, Hassan Y. Aboul-Enein, Mohamed Zakaria Gad. Journal of Chromatographic Science. 53(1):66-72.
Journal 2014	Chemical composition and biological activity of essential oils of cumin and coriander fruits from Egypt. Hanafi, R. S., Sobeh, M., Ashour, M. L., El-Readi, M. Z., Desouky, S. Y., Niess, R., Abad, A. H. and Wink, M. The Natural Product Journal, 4(1):63-69.
Conference 2014	Insights on vitamin D’s role in cardiovascular disease: investigating the association of 25-hydroxyvitamin d with the dimethylatedarginines. Mohamed A. Abu el Maaty, Sally I. Hassanein, Rasha S. Hanafi and Mohamed Z. Gad. Conference of “Vitamin D and Human Health: From the Gamete to the Grave”, Queen Mary University of London, United Kingdom.

2013

Journal 2013	Insights on Vitamin D's Role in Cardiovascular Disease: Investigating the Association of 25-hydroxy vitamin D with the Dimetylated Arginines. Mohamed A. Abu el Maaty, Sally I. Hassanein, Rasha S. Hanafi and Mohamed Z. Gad, Journal of Nutritional Science and Vitaminology. 59(3):172-7
Journal 2013	Determination of the Design Space of the HPLC Analysis of Water Soluble Vitamins. Hebatallah A. Wagdy, Rasha S. Hanafi, Rasha M. El-Nashar, Hassan Y. Aboul-Enein. Journal of Separation Science. 36(11):1703-10.
Journal 2013	In Vitro and In Vivo Anti-Inflammatory and Cytotoxic Capacities of Dietary Phenolics Isolated From Corchorus Olitorius and Vitis Vinifera. Heba Handoussa, Rasha Hanafi, Islam Eddiasty, Mohamed El-Gendy, Micheal Linscheid, Laila Mahran, Nahla Ayoub. Journal of Functional Foods, 5(3):1204-1216.
Journal 2013	Interplay of Vitamin D and Nitric Oxide in Post-Menopausal Knee Osteoarthritis. Mohamed A. Abu el Maaty, Rasha S. Hanafi, Samir El-Badawy, Mohamed Zakaria Gad. Aging Clinical and Experimental Research, 26 (4) 363-36.
Journal 2013	Predictability of Enantiomeric Chromatographic Behavior on Various Chiral Stationary Phases Using Typical Reversed Phase Modeling Software. Heba Wagdy, Rasha Hanafi, Rasha El-Nashar, Hassan Aboul-Enein. Chirality, 25(9): 506–513.

2012

Conference 2012	Computer-Assisted HPLC Method Development using DryLab® for determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera. Heba Handoussa, Rasha Hanafi, Michael Linscheid, Laila Mahran and Nahla Ayoub. International Conference on Pharmaceutical Technologies, Future University, Cairo.
Journal 2012	Computer-Assisted HPLC Method Development for Determination of Tolmetin and Possible Kinetic Modulators of its Oxidative Metabolism in Vivo. Rasha Hanafi, Hilde Spahn-Langguth, Laila Mahran, Ola Heikal , Abeer Hanafy, Hans Rieger, Imre Molnár, Hassan Aboul-Enein. Chromatographia, 75:469–477.
Conference 2012	In-vivo evaluation of a formulated bioadhesive fluconazole vaginal tablet. N. Afifi, A. Makky, A. Hashad, R. Hanafi and K. El Hodeiby. 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Instanbul, Turkey.
Workshop 2012	HPLC Method Development Basics. Dr. Rasha Hanafi, trainer and speaker : HPLC Method Development Basics , Workshop for industrial pharmacists, 2012.
Conference 2012	Predictability of Chromatographic Behavior on Chiral Stationary Phases Using Computer-Assisted RP-HPLC Method Development Software. HebatALLAH Wagdy, Rasha Hanafi, Rasha El-Nashar, Hassan Aboul-Enein. Chirality, USA.
Conference 2012	Computer-Assisted HPLC Method Development and Validation for Vitamin D2, D3 and their Metabolites in Blood. Clinical Application on Post Menopausal Egyptian Females. Mohamed A. Abu el Maaty, Rasha S. Hanafi, Mohamed Z. Gad. 2nd International Conference on Vitamins, Denmark.
Conference 2012	Vitamin D Status & Knee Osteoarthritis Incidence. A Clinical /Comparative-Assay Study OF HPLC-UV Versus ELISA. Mohamed A. Abu el Maaty , Rasha S. Hanafi , Mohamed Z. Gad, 12th Moroccan Congress of clinical chemistry and laboratory medicine, Morocco.
Journal 2012	Association of suboptimal 25-hydroxyvitamin D levels with knee osteoarthritis incidence in post-menopausal Egyptian women. Mohamed A. Abu el Maaty, Rasha S. Hanafi, Samir El Badawy, Mohamed Z. Gad. Rheumatology International,33 (11): 2903-2907. Top Read Article of 2012 on MDLinx.com.
Conference 2012	Is there a relationship between vitamin D deficiency and the incidence of osteoarthritis? A clinical/comparative assay study of HPLC-UV versus ELISA. Mohamed Aboul- Maaty, Rasha Sayed Hanafi, Mohamed Zakaria Gad. Clinical Chemistry and Laboratory Medicine, 50(4): A94 (2012).
Conference 2012	Insights on vitamin D’s role in cardiovascular disease: investigating the association of 25-hydroxyvitamin D with the dimethylatedarginines. Mohamed A. Abu el Maaty, Sally I. Hassanein, Rasha S. Hanafi and Mohamed Z. Gad. Clinical Chemistry and Laboratory Medicine 50(4): A94.

2011

Journal 2011	Baclofen ester and carbamate prodrug candidates: A simultaneous chromatographic assay, resolution-optimized with DryLab® Rasha Hanafi; Salwa Mosad; Khaled Abouzid; Raimund Nieß; Hilde Spahn-Langguth. Journal of Pharmaceutical and Biomedical Analysis 56 (2011) 569– 576.
Journal 2011	Application of biodegradable nanoparticles in liver targeting of tacrolimus. Tammam S., Hanafi R., Afifi N., Heikal O. : Application of biodegradable nanoparticles in liver targeting of tacrolimus , AIP Conf. Proc., Volume 1326, pp. 120-127.

2010

Conference 2010	Application of biodegradable nanoparticles in liver targeting of tacrolimus Nagia N. Afifi, Ola A. Heikal, Rasha S. Hanafi, Salma N. Tammam :Application of biodegradable nanoparticles in liver targeting of tacrolimus, 5th BioNano Tox and applications research conference, Arkansas, USA,2010.
Workshop 2010	Baclofen brain targeting: high CNS levels via baclofen methyl carbamate. Salwa Mosaad, Raimund Niess, Khaled Abou-Zeid, Rasha Hanafi, Reham Abdel-kader, Hilde Spahn-Langguth : Baclofen brain targeting: high CNS levels via baclofen methyl carbamate , 9th international meeting of the society of study of xenobiotics, Istanbul.
workshop by R. Hanafi 2010.pdf	HPLC method development basics & troubleshooting. Prof. Hassan Aboul-enein and Dr. Rasha Sayed Hanafi, HPLC method validation, ICH guidelines, workshop delivered to the industrial pharmaceutical society, Cairo, Egypt. Speaker and Trainer.
Conference 2010	Baclofen brain targeting: High CNS levels via baclofen methyl carbamate. Mosad, S., R. Niess, K. Abou-Zeid, R. Hanafi, R. Abdel-Kader, and H. Spahn-Langguth. Drug Metabolism Reviews, 42: 51-51.

2009

Conference 2009

Tolmetin phase-II metabolism and conjugate transport in rats: influence of coadministration of potential MRP2-inhibitors. Rasha Hanafi, Abeer Hanafy, Laila Mahran, Raimund Nieß, Hilde Spahn-Langguth, Jahrestagung der DPhG, Jena, Germany.

2006

Conference 2006

Talinolol drug-drug interaction studies: spironolactone, ciprofloxacin, and carvedilol. Spahn-Langguth H, Hanafi RS, Bradry N, Frenzel D, Hanafy A. Joint meeting of the Czech, German and Hungarian Pharmaceutical societies, Marburg, Germany.

2004

Journal 2004	Normal phase chromatographic determination of chlorphenoxamine hydrochloride, caffeine and 8-chlorotheophylline. Y.M. Dessouky, H. H. Hassanein, M. Abdul-Azim Mohammad and R. S. Hanafi. Bulletin of the Faculty of Pharmacy of Cairo University., Vol. 42(1), p.53- 62.
Journal 2004	Spectrophotometric and spectrofluorometric determination of Pizotifen malate. Y.M. Dessouky, H. H. Hassanein, M. Abdul-Azim Mohammad and R. S. Hanafi. Bulletin of the Faculty of Pharmacy of Cairo University, 42(1): 41- 51.

2002

Conference 2002

Spectrophotometric and spectrofluorimetric determination of pizotifen malate Y.M. Dessouky, H. H. Hassanein, M. Abdul-Azim Mohammad and R. S. Hanafi. XXV111 conference of pharmaceutical sciences by the pharmaceutical society of Egypt, Cairo, Egypt, 2002.

Prof. Dr. Mohammad Abdelhalim

Email: mohammad.abdel-halim @guc.edu.eg
Office:B5-133
Ext: 3407

Biography

Dr. Mohammad Abdel-Halim is a lecturer of pharmaceutical chemistry at the Faculty of Pharmacy and Biotechnology, graduated from Faculty of Pharmacy, Cairo University in 2001 (excellent with honor). He joined the GUC since 2005 as a teaching assistant then he was promoted to assistant lecturer after getting his Master’s degree from the Faculty of postgraduate studies-GUC in 2009. He earned his doctoral degree in medicinal chemistry from Saarland University in 2013.

Research Interests

Development of histone deacetylase inhibitors as anticancer agents
Development of PDE5 inhibitors with novel binding site.
Development of DYRK1A kinase inhibitors for treatment of neurodegenerative diseases and Clk 1/4 kinase inhibitors for targeting cancer cells.
Development of novel Anti-infective.

Publications

2020

Journal 2020	Saad E.M., El Gohary N.A, Abdel-Halim M., Handoussa H., El Nashar R. M. and Mizaikof B. (2020)” Molecularly Imprinted Polymers for Selective Extraction of Rosmarinic Acid from Rosmarinus officinalis L.” J Food Chem. 335, 127644. IF 6.306
Journal 2020	El-Hossary E, Abdel-Halim M,. Ibrahim E, Pimentel-Elardo SM, Handoussa H, Holzgrabe U, Abdelmohsenn UR. (2020) ” Natural Products Repertoire of the Red Sea” Mar. Drugs 18, 457. IF 4.379.
Journal 2020	Abdel Karim SE, Youssef YH, Abdel-Halim M, Frakolaki E, Vassilaki N, Zoidis G, Ahmed NS, Abadi AH (2020) ‘’Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamate’’ Bioorg Chem. 102, 104089. IF 4.83.
Journal 2020	Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M. (2020) ‘’Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents’’ Bioorg Chem. 99, 103759. IF. 4.83
Journal 2020	ElHady AK, Shih SP, Chen YC, Liu YC, Ahmed NS, Keeton AB, Piazza GA, Engel M, Abadi AH, Abdel-Halim M. (2020) ‘‘Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors’’ Bioorg Chem. 98,103742. IF. 4.83

2019

Journal 2019	Hammam MA, Abdel-Halim M, Madbouly A, Wagdy HA, El Nashar RM; Computational design of molecularly imprinted polymer for solid phase extraction of moxifloxacin hydrochloride from Avalox® tablets and spiked human urine samples; Microchemical Journal; 2019; 148: 51-56; doi.org/10.1016/j.microc.2019.04.063.
Journal 2019	Hassan R, Tammam SN, Safy SE, Abdel-Halim M, Asimakopoulou A, Weiskirchen R and Mansour S; Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis; European Journal of Pharmaceutics and Biopharmaceutics; 2019; 134:96-106; doi: 10.1016/j.ejpb.2018.11.018.

2018

Journal 2018	Darwish SS, Abdel-Halim M, ElHady AK, Salah M, Abadi AH, Becker W and Engel M; Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors; Part II: Identification of the cyclopropylamide moiety as a key modification; European Journal of Medicinal Chemistry; 2018; 158:270-285; doi: 10.1016/j.ejmech.2018.08.097.
Journal 2018	ElMasry S, Hathout R, Abdel-Halim M and Mansour S; In Vitro transdermal delivery of sesamol using oleic acid chemically-modified gelatin nanoparticles as a potential breast cancer medication; Journal of Drug Delivery Science and Technology; 2018; 48: 30-39; DOI: 10.1016/j.jddst.2018.08.017.
Journal 2018	Darwish SS, Abdel-Halim M, Salah M, Abadi AH, Becker W and Engel M; Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. European Journal of Medicinal Chemistry; 2018; 157:1031-1050; doi: 10.1016/j.ejmech.2018.07.050.
Journal 2018	Abdel-Halim M, Abadi AH and Engel M; Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ); MedChemComm; 2018; 9(6):1076-1082; doi: 10.1039/c8md00100f.
Journal 2018	Salah M, Abdel-Halim M and Engel M; Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core; MedChemComm; 2018; 9(6):1045-1053; doi: 10.1039/c8md00142a. *Authors have equal contribution
Journal 2018	El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW and Abadi AH; Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors. Archiv der Pharmazie; 2018; 351(5):e1800018; doi: 10.1002/ardp.201800018.

2017

Journal 2017

ElHady AK, Abdel-Halim M, Abadi AH and Engel M; Development of selective Clk1 and -4 inhibitors for cellular depletion of cancer-relevant proteins; Journal of Medicinal Chemistry; 2017; 60(13):5377-5391; doi: 10.1021/acs.jmedchem.6b01915.

2016

Journal 2016	Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK and Engel M; Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD); European Journal of Pharmaceutical Sciences; 2016; 93:405-9; doi: 10.1016/j.ejps.2016.08.016.
Journal 2016	Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA and Abadi AH; Synthesis and optimization of new 3,6-disubstitutedindole derivatives and their evaluation as anticancer agents targeting the MDM2/MDMx Complex; Chemical Pharmaceutical Bulletin (Tokyo); 2016; 64(1):34-41; doi: 10.1248/cpb.c15-00608.

2014

Journal 2014

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW and Engel M; Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ; Journal of Medicinal Chemistry; 2014; 57(15):6513-30; doi: 10.1021/jm500521n.

2013

Journal 2013

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW and Abadi AH; Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53. Bioorganic and Medicinal Chemistry; 2013; 21(23):7343-56; doi: 10.1016/j.bmc.2013.09.055.

2011

Journal 2011

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim, Mohamed S. M. Ali. : : Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-ß-Carboline Hydantoin and Tetrahydro-ß-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors , Int. J. Med. Chem,, 2011.
Article ID 562421, 9 pages (2011), Doi:1155/2011/562421

Conference 2011

Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution
Mohammed Weam, Mohammad Abdel-Halim, Raimund Niess, Bernard D. Gary, Heather N. Tinsley, Jason Whitt, Gary A. Piazza, Matthias Engel, Rolf W. Hartmann, Ashraf H. Abadi : Altering the Balance between COX2 and PDE5 Inhibitory Activities of Celecoxib by Modulating the Nature of the Core Ring and Peripheral Rings Substitution , Frontiers in Medicinal Chemistry, 2011.
Saarbrucken, Germany

2010

Journal 2010

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective
Ashraf H. Abadi, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Mohammad Abdel-Halim : Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective , Eur J Med Chem, 2010.
45, 1278-86

Patent

Patent Application; Engel M, Abdel-Halim M, Abadi AH; Allosteric inhibitors of atypical protein kinases C; PCT/EP2014/074971 and WO2015075051A1.

2009

Conference 2009

Novel Tadalafil Analogues with New Stereochemical Perspective
Ashraf H. Abadi, Mohamed Saleh, Mohammad Abdel-Halim, Jochen Lehmann, Gary A. Piazza : Novel Tadalafil Analogues with New Stereochemical Perspective , German Pharmaceutical Society Annual Meeting, 2009.
Jena, Germany

Conference 2009

Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents
Ashraf H. Abadi, Mohammed Abdel-halim, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza : Design and Synthesis of Novel ß-Carboline Derivatives as Potential Phosphodiesterase Inhibitors and Anticancer Agents , Dubai International Pharmaceuticals and Technologies (Duphat), , 2009.

Assoc. Prof. Nermin Salah

Email: nermin.salah@guc.edu.eg
Office:B5-105
Ext: 3429

Biography

Nermin Salah Ahmed is an accomplished Egyptian scientist and entrepreneurial leader, specializing in Medicinal and Pharmaceutical Chemistry, with a PhD degree to her name. With a relentless drive to advance scientific research, she heads a dynamic team focused on developing active pharmaceutical moieties that hold immense potential as antivirals, anticancer agents, and treatments for Alzheimer's disease.

Recognized for her exceptional work, Dr. Nermin has garnered numerous national and international research grants to support her projects (STDF, DAAD, BMBF, ASRT, EU Erasmus). Her exceptional leadership have earned her the prestigious TechWomen fellowship, UNILEAD, Biovision.nxt. She was a visiting scholar at TU Dresden and currently a TU Dresden ambassador.

Dr. Nermin was honored with the esteemed Hubert Humphrey fellowship at Penn State University and UC Berkeley. Dr. Nermin serves as a program manager at the “innovator Support Fund” and as the national coordinator for Pillar 4, OECD Egypt Program. Through her unwavering dedication, pioneering research, and visionary leadership, Dr. Nermin is leaving an indelible mark on the scientific and entrepreneurial communities, both locally and internationally.

Research Interests

Design and synthesis of novel tetrahydro-β-carbolines and their use as PDE5 inhibitors.
Design and synthesis of novel tetrahydro-β-carbolines and their use as dual PDE5/acetylcholine esterase inhibitors for treatment of Alzheimer.
The design of cGMP elevating agents with potential use in treatment of cancer via apoptotic and autophagic pathways. (DAAD funded project)
Design and synthesis of tamoxifen and its flexible analogues adopting an alternative prodrug approach to improve pharmacogenomic susceptibility. (STDF funded project)
Design and synthesis of novel triphenylethylenes and their biological evaluation as antiestrogenic moieties and anticancer agents. (STDF funded project)
Metabolic studies of oxygen containing tamoxifen analogues.
YES/ MTT/ ER binding assays.
Design and synthesis of novel triphenylethylenes with potential antiviral activities.
EBOV replicon assays
Design and synthesis of novel anti-HCV agents that act as NS5A inhibitors. (STDF funded project)

Publications

2021

Journal 2021

Abdel Razeq, S.A., Abdel Aziz, S.E., Ahmed, N.S. (2021) 1177, DOI: 10.1016/j.jchromb.2021.122804 Mousa, M.H.A., Ahmed, N.S., Schwedtmann, K., Frakolaki, E., Vassilaki, N., Zoidis, G., Weigand, J.J., Abadi, A.H. Pharmaceuticals (2021) https://doi.org/10.3390/ph14040292

2020

Journal 2020	Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates SEA Karim, YH Youssef, M Abdel-Halim, E Frakolaki, N Vassilaki,Grigoris Zoidis, Nermin S Ahmed, Ashraf H Abadi Bioorganic Chemistry 102, 104089
Journal 2020	Synthesis of novel flexible tamoxifen analogues to overcome CYP2D6 polymorphism and their biological evaluation on MCF‐7 cell line. NS Ahmed, J Wober Drug Development Research 81 (4), 444-455
Journal 2020	Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors AK ElHady, SP Shih, YC Chen, YC Liu, NS Ahmed, AB Keeton, GA Piazza, Matthias Engel, Ashraf H Abadi, Mohammad Abdel-Halim Bioorganic Chemistry, 103742

2018

Journal 2018	Nermin S. Ahmed, Tadalafil: 15 years' journey in male erectile dysfunction and beyond. Drug Dev. Res., 2018, 1-19.
Journal 2018	Ramsis T., Abdel Karim S. , Vassilaki N. , Frakolaki E. , Kamal A. , Zoidis G. , Ahmed N.S. and Abadi A.H. Expanding the Chemical Space of Anti-HCV NS5A inhibitors by Stereochemical Exchange and Peptidomimetic Approaches. Arch. Pharm. Chem. Life Sci., 2018, 1-10.

2016

Journal 2016	Design and synthesis of novel flexible ester-containing analogs of tamoxifen and their evaluation as anticancer agents Elghazawy, Engel, Hartmann, Hamed, Ahmed & Abadi : Design and synthesis of novel flexible ester-containing analogs of tamoxifen and their evaluation as anticancer agents , Future Medicinal Chemistry, 2016.
Journal 2016	Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism Nermin S. Ahmed , Nehal H. Elghazawy , Ahmed K. ElHady , Matthias Engel , Rolf W. Hartmann , Ashraf H. Abadi : Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism , European Journal of medicinal
Conference 2016	Design and Synthesis of Novel Non CYP 2D6 mediated Tamoxifen Analogues Nehal H. Elghazawy, Nermin S. Ahmed, Bianca Liederer, Rolf Hartmann, Ashraf H. Abadi : Design and Synthesis of Novel Non CYP 2D6 mediated Tamoxifen Analogues , Pharmaceutica 2016, 2016.
Conference 2016	Design and Synthesis of Novel Tamoxifen Analogues and Their Evaluation as Selective Estrogen Receptor Modulators . 7th International Scientific Conference of Faculty of Pharmacy, Cairo , Rasha M. Rashied, Nermin S. Ahmed, Jannette Wober, Günter Vollmer, Ashraf H. Abadi : Design and Synthesis of Novel Tamoxifen Analogues and Their Evaluation as Selective Estrogen Receptor Modulators . 7th International Scientific Conference of Faculty of Pharmacy, Cairo , , 7th International Scientific Conference of Faculty of Pharmacy, Cairo., 2016

2015

Journal 2015

Structure-based design of novel tetrahydro-beta-carboline derivatives with a hydrophilic side chain as potential phosphodiesterase inhibitors
Ahmed K. Elhady, Sara C. Sigler, Nazih Noureldin, Joshua C. Canzoneri, Nermin S. Ahmed,Gary A. Piazza, Ashraf H. Abadi : Structure-based design of novel tetrahydro-beta-carboline derivatives with a hydrophilic side chain as potential phosphodiesterase inhibitors , Sci. Pharm., 2015.

Conference 2015

An Alternative Prodrug Approach to Improve Pharmacogenomic Susceptibility of Tamoxifen and its Flexible Analogues
Nehal H. ELGhazawy , Ashraf. H. Abadi , Rolf Hartmann , Matthias Engel, Nermin S. Ahmed : An Alternative Prodrug Approach to Improve Pharmacogenomic Susceptibility of Tamoxifen and its Flexible Analogues , Duphat, 2015.

2014

Journal 2014	Ahmed N. S., Elgendy M., Laufer S., Abadi A. H. A novel series of tetrahydro-beta carbolines induces cell death via autophagy in human metastatic melanoma. Arch. Pharm. Chem. Life Sci., 2014, 347, 398-406.
Conference 2014	Discovery of Novel Series of Tetrahydro-beta Carbolines Inducing Autophagic Cell Death in Human Metastatic Melanoma Nermin S. Ahmed , Mohamed Elgendy , Stefan Laufer , Ashraf H. Abadi : Discovery of Novel Series of Tetrahydro-beta Carbolines Inducing Autophagic Cell Death in Human Metastatic Melanoma , Building International Networks for Enhancement of Research, Jordan, 2014.
Conference 2014	STRUCTURE BASED DESIGN OF NOVEL TETRAHYDRO-BETA-CARBOLINES REVEALING NOVEL BINDING MODE INSIDE PDE5 POCKET. Ahmed K. ElHady, Nermin S. Ahmed, Joshua Canzoneri, Gary A. Piazza, Ashraf H. Abadi : STRUCTURE BASED DESIGN OF NOVEL TETRAHYDRO-BETA-CARBOLINES REVEALING NOVEL BINDING MODE INSIDE PDE5 POCKET. , Building International Networks for Enhancement of Research, Jordan, 2014.

2013

Journal 2013

El-Gamil D.S , Ahmed N.S., Gary B.D., Piazza A.G., Engel M., Hartmann R.W., Abadi A.H. Design of Novel β-carboline Derivatives with Pendant 5-bromothienyl and their Evaluation as Phosphodiesterase-5 Inhibitors. Archiv der Pharmazie, 2013, 346 (1), 23-33.

2012

Journal 2012	Design of Novel ß-carboline Derivatives with Pendant 5-bromothienyl and their Evaluation as Phosphodiesterase-5 Inhibitors Dalia S. El-Gamil , Nermin S. Ahmed, Bernard D. Gary, Gary A. Piazza, Matthias Engel, Rolf w. Hartmann, Ashraf H. Abadi : Design of Novel ß-carboline Derivatives with Pendant 5-bromothienyl and their Evaluation as Phosphodiesterase-5 Inhibitors , Archiv der Pharmazie, 2012.
Journal 2012	Exploring the PDE5 H-pocket by Ensemble Docking and Structure-based Design and Synthesis of Novel ß-Carboline Derivatives Nermin S. Ahmed, Amal H. Ali, Shreen M. El-Nashar, Bernard D. Gary, Alexandra M. Fajardo, Heather N. Tinsley, Gary A. Piazza, Matthias Negri, Ashraf H. Abadi : Exploring the PDE5 H-pocket by Ensemble Docking and Structure-based Design and Synthesis of Novel ß-Carboline Derivatives , European Journal of Medicinal Chemistry, 2012.
Conference 2012	Design and Synthesis of Novel Beta-carbolines as Kinesin Eg5 inhibitors And Potential Anticancer Agents; Nermin S. Ahmed, Naowras Al. Obaidi, Stefan Laufer, Ashraf H. Abadi : Design and Synthesis of Novel Beta-carbolines as Kinesin Eg5 inhibitors And Potential Anticancer Agents; , Biovision, 2012.
Journal 2012	Synthesis, cytotoxic activities of novel tetra-hydro- ß-carboline derivatives and thei evaluation as Kinesin Eg5 inhibitors Nermin S. Ahmed , Mohamed El Gendy , Naowras Al-Obaidi , Stefan Laufer , Ashraf H. Abadi : Synthesis, cytotoxic activities of novel tetra-hydro- ß-carboline derivatives and thei evaluation as Kinesin Eg5 inhibitors , Interfacing Chemical Biology and Drug Discovery, 2012.
Conference 2012	DESIGN AND SYNTHESIS OF NOVEL TETRAHYDRO- ß–CARBOLINES ASKINESIN Eg5 INHIBITORS AND THEIR ANTI-CANCER EFFECT ON MELANOMA, LEUKEMIA AND OSTEOSARCOMA CELL LINES Nermin S. Ahmed, Mohamed ELGendy, Stefan Laufer , Ashraf H. Abadi : DESIGN AND SYNTHESIS OF NOVEL TETRAHYDRO- ß–CARBOLINES ASKINESIN Eg5 INHIBITORS AND THEIR ANTI-CANCER EFFECT ON MELANOMA, LEUKEMIA AND OSTEOSARCOMA CELL LINES , Biovision, 2012.

2011

Journal 2011

Nermin S. Ahmed, Bernard D. Gary, Heather N. Tinsley, Gary A. Piazza, Stefan Laufer, and Ashraf H. Abadi Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-β-carboline Derivatives as Novel PDE5 Inhibitors, Archiv der Pharmazie, 2011, 344(3), 149-57.

2010

Journal 2010	A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors Nermin S. Ahmed, Bernard D. Gary, Gary A. Piazza, Stefan Laufer, and Ashraf H. Abadi : A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors , Med.Chem., 2010.
Book 2010	Design, Synthesis and Structure-Activity Relationship of Novel Tadalafil Analogues and Their Evaluation as Phosphodiesterase 5 Inhibitors and Anticancer Agents Thesis 2010.pdf Nermin S. Ahmed : Design, Synthesis and Structure-Activity Relationship of Novel Tadalafil Analogues and Their Evaluation as Phosphodiesterase 5 Inhibitors and Anticancer Agents , PhD thesis, 2010.

2009

Journal 2009

Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents
: Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents , Arzneimittelforschung, 2009.

Dr. Nesrine Elgohary

Email: nesrine.elgohary@guc.edu.eg
Office:B5-104

Biography

Dr. Nesrine El Gohary graduated from the Faculty of Pharmacy, Ain Shams University in 2003. Following her graduation Dr. El Gohary was appointed as an Organic Chemistry Teaching Assistant at the Faculty of Pharmacy, Misr International University. After wards, Dr. El Gohary worked as a Quality Control Analyst, Chromatography Unit, National Organization for Drug Control and Research (NODCAR). In September 2006, Dr. El Gohary was appointed as a Faculty member in the Pharmaceutical Chemistry Department at the Faculty of Pharmacy and Biotechnology, GUC. Dr. El Gohary earned both her Masters and PhD. from the German University in Cairo in 2009 and 2015, respectively. Dr. El Gohary was the Principle investigator (2016-2017) for DAAD-BMBF funded project ‘’ Design and application of molecularly imprinted polymers as drug delivery vehicles’’. Dr. El Gohary currently holds the position of a lecturer and is teaching General Basic Chemistry, Pharmaceutical Analytical Chemistry and Physical Chemistry courses. In addition to teaching and research, Dr. El Gohary is a member of the advising committee, QMAC as well as the mentoring program.

Research Interests

Molecularly Imprinted Polymers

Electrochemical Sensors
Pharmaceutical Analysis
Flow Injection Analysis
Solid phase extraction with functionalized materials
Drug Delivery
Magnetic nanoparticles

Current projects:

Molecularly imprinted polymers for drug delivery applications.
Molecularly imprinted polymers for isolation of active components from different matrices.
Fabrication of robotic molecularly imprinted polymers.

Dr. El Gohary is currently collaborating with:

Institute of Analytical and Bioanalytical Chemistry, Ulm University.
Medical micro and Nano robotics lab, GUC.

Publications

2023

Journal 2023	Adel Ehab Ibrahim#, Nesrine Abdelrehim El Gohary#, Dina Aboushady, Liza Samir, Shereen Ekram Abdel Karim, Magy Herz, Baher I. Salman, Ahmed Al-Harrasi, Rasha Hanafi, Sami El Deeb. "Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review." Journal of Chromatography A*. Volume 1706, 13 September 2023, 464214. https://doi.org/10.1016/j.chroma.2023.464214..
Journal 2023	Abdel-Mageed, H. M., Fouad, S. A., Nada, D., Makar, R. R., Teaima, M. H., EL Gohary, N. A., & AbuelEzz, N. Z. (2023). A design of experiment approach for optimized production of encapsulated trypsin using nano spray drying: Comparative physicochemical and kinetic characterization. Biocatalysis and Biotransformation, 1-18.‏
Journal 2023	Soliman, M., Shanan, N., Eissa, G., Mizaikoff, B., & El Gohary, N. A. (2023). In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model. Journal of Drug Targeting, 31(8), 878-888.‏

2022

Journal 2022	Abdel-Mageed, H.M., Nada, D., Radwan, R.A., Mohamed, S.A. and Gohary, N.A.E., 2022. Optimization of catalytic properties of Mucor racemosus lipase through immobilization in a biocompatible alginate gelatin hydrogel matrix for free fatty acid production: a sustainable robust biocatalyst for ultrasound-assisted olive oil hydrolysis. 3 Biotech, 12(11), pp.1-16.
Journal 2022	El Gohary, N.A., Mahmoud, A., Ashraf Nazmy, M., Zaabalawi, R., El Zahar, L., Khalil, I.S. and Mitwally, M.E., 2022. Magnetic polycaprolactone microspheres: drug encapsulation and control. International Journal of Polymeric Materials and Polymeric Biomaterials, pp.1-11.
Journal 2022	Megahed, S.H., Abdel-Halim, M., Hefnawy, A., Handoussa, H., Mizaikoff, B. and El Gohary, N.A., 2022. Molecularly Imprinted Solid Phase Extraction Strategy for Quinic Acid. Polymers, 14(16), p.3339.

2020

Journal 2020	Saad, E.M., El Gohary, N.A., El-Shenawy, B.M., Handoussa, H., Klingner, A., Elwi, M., Hamed, Y., Khalil, I.S., El Nashar, R.M. and Mizaikoff, B., 2020. Fabrication of Magnetic Molecularly Imprinted Beaded Fibers for Rosmarinic Acid. Nanomaterials, 10(8), p.1478. IF 4.5
Journal 2020	Saad EM, El Gohary NA, Abdel-Halim M, Handoussa H, El Nashar RM, Mizaikoff B., 2020. Molecularly Imprinted Polymers for Selective Extraction of Rosmarinic Acid from Rosmarinus officinalis L. Food Chemistry, 335, 127644. IF 6.3

2019

Journal 2019

Abdel-Mageed, H., Radwan, R., AbuelEzz, N., Nasser, H., El Shamy, A., Abdelnaby, R. and EL Gohary N. (2019). Bioconjugation as a smart immobilization approach for α-amylase enzyme using stimuli-responsive Eudragit-L100 polymer: a robust biocatalyst for applications in pharmaceutical industry. Artificial cells, Nanomedicine and Biotechnology, 47:1, 2361-2368, DOI: 10.1080/21691401.2019.1626414

2018

Journal 2018	1- Hosny, H., El Gohary, N. A., Saad, E., Handoussa, H. and El Nashar R. M., (2018) Isolation of sinapic acid from Broccoli using molecularly imprinted polymers. Journal of Separation Science, 41 (5), 1164-1172.
Journal 2018	Khalil, I.S.M., Tabak, A.F, Hamed, Y., Tawakol, M., Klingner, A., El Gohary N. A., Mizaikoff, B. and Sitti, M.,(2018) Independent Actuation of Two-Tailed Microrobots, IEEE Robotics and Automation Letters, DOI 10.1109/LRA.2018.2801793.

2017

Journal 2017	El Nashar, R.M., Ghani, N.T.A., El Gohary, N.A., Barhoum, A. and Madbouly, A. (2017). Molecularly imprinted polymers based biomimetic sensors for mosapride citrate detection in biological fluids. Materials Science and Engineering: C, 76, 123-129.
Journal 2017	El Gohary, N. A., Madbouly, A., El Nashar, R. M., & Mizaikoff, B. (2017) Voltammetric determination of valaciclovir using a molecularly imprinted polymer modified carbon paste electrode. Electroanalysis.

2015

Journal 2015

Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir
Nesrine Abdelrehim El Gohary Adel Madbouly Rasha Mohamed El Nashar Boris Mizaikoff : Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir , Biosensors and Bioelectronics, 2015.

2011

Journal 2011

POTENTIOMETRIC DETERMINATION OF SIBUTRAMINE USING BATCH AND FLOW INJECTION ANALYSIS
Nesrine A. El Gohary, Rasha M. El Nashar and Hassan Y. Aboul-Enien : POTENTIOMETRIC DETERMINATION OF SIBUTRAMINE USING BATCH AND FLOW INJECTION ANALYSIS , Analytical letters, 2011.

Dr. Marwa Hany

Email: marwa.hany@guc.edu.eg
Office:B7.206
Ext:3416

Email:shereen.ekram@guc.edu.eg
Office:B5.134
Ext:

Biography

Dr. Shereen Ekram is a post-doctoral associate with 15 years‟ experience in Organic Chemistry and Medicinal Chemistry Fields, Faculty of Pharmacy & Biotechnology, German University in Cairo. She acquired her PhD in 2018 and her M. Sc. in 2011 from the German University in Cairo in the field of Pharmaceutical chemistry. She received her B.Sc. degree from Cairo University in 2007.

Research Interests

She was fortunate to have the chance to work both in the field of Pharmaceutical analysis during my M.Sc. and Pharmaceutical design and synthesis during my PhD.

PhD work was particularly in the field of anti-viral drugs namely anti-HCV NS5A Inhibitors using natural amino acids, isolation of the pure products and elucidation of such complex structures. Elucidation included LC/Mass spectrometry and NMR spectroscopy
In M.Sc work, new and effective spectrophotometric, colorimetric and potentiometric method was developed for the assay of anticancer drugs and had a chance to work on different analytical instruments: UV/VIS Spectrophotometer, pH meter, a potentiometer and flow injection analysis, in addition to the High performance liquid chromatography (HPLC).

Publications

2023

Journal 2023

Adel Ehab Ibrahim#, Nesrine Abdelrehim El Gohary#, Dina Aboushady, Liza Samir, Shereen Ekram Abdel Karim, Magy Herz, Baher I. Salman, Ahmed Al-Harrasi, Rasha Hanafi, Sami El Deeb*. "Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review." Journal of Chromatography A. Volume 1706, 13 September 2023, 464214. https://doi.org/10.1016/j.chroma.2023.464214.

2020

Journal 2020

Shereen E.Abdel Karim, Youssef H.Youssef, Mohammad Abdel-Halim, Efseveia Frakolaki, NikiVassilaki, GrigorisZoidis, Nermin S.Ahmed, Ashraf H.Abadi. Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates. Bioorganic Chemistry, Volume 102, September 2020, 104089.

2018

Journal 2018

Ramsis, T.M., Abdel Karim, S.E., Vassilaki, N., Frakolaki, E., Kamal, A.A., Zoidis, G., Ahmed, N.S. and Abadi, A.H., 2018. Expanding the chemical space of anti‐HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches. Archiv der Pharmazie, p.1800017.

2014

Journal 2014

Shereen. E. Abdel Karim, Raafat. A. Farghaly, Rasha. M. El-Nashar, Ashraf. H. Abadi Chemical Rapid Communications Vol.2 No.3, December 2014 ISSN: 2325-9892 (Print) 2325-9906 (Online). Spectrophotometric Determination of Imatinib Mesylate using Charge Transfer Complexes in Pure Form and Pharmaceutical Formulation.

2012

Journal 2012

Shereen E. Abdel Karim, Rasha M. El-Nashar, Ashraf H. Abadi. Int. J. Electrochem. Sci., 7, 2012, 9668 – 9681, Potentiometric Determination of Imatinib under Batch and Flow Injection Analysis Conditions.

Dr. Dina Hady Ismail Abou-shady

Email: dina.abou-shady@guc.edu.eg
Office: B1.205

Biography

Dina is an Assistant Lecturer and Post-Doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). Dina received her B.Sc. degree in 2014 from the faculty of Pharmacy and Biotechnology, GUC. She acquired her M. Sc. in 2016 in pharmaceutical chemistry and her PhD in 2021 specialized in the field of Instrumental analysis, from the GUC where part of the PhD was done in the institute of Pharmacy, Freie Universitaet Berlin, Germany and the other part was achieved in the GUC. She has been teaching various theoretical and practical courses in Instrumental analysis unit in the pharmaceutical chemistry department. As well as, teaching pharmaceutical engineering summer course in GUC Berlin campus. In addition to teaching and research, she is also a member of the advising and mentoring committees.

In PhD, research project was about developing a novel chromatographic method applying the quality by design approach in which special focus on method robustness using Design of Experiment DoE approach. Method development was applied on two majorly dissimilar chiral separation methodologies, viz. Ultra High Pressure Liquid Chromatography (UHPLC) and Supercritical Fluid Chromatography (SFC) for bioanalytical application.

Research Interests

Publications

2023

Journal 2023

Adel Ehab Ibrahim#, Nesrine Abdelrehim El Gohary#, Dina Aboushady, Liza Samir, Shereen Ekram Abdel Karim, Magy Herz, Baher I. Salman, Ahmed Al-Harrasi, Rasha Hanafi, Sami El Deeb*. "Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review. " Journal of Chromatography A. Volume 1706, 13 September 2023, 464214. https://doi.org/10.1016/j.chroma.2023.464214.

2022

Journal 2022

Quality by design approach for enantioseparation of terbutaline and its sulfate conjugate metabolite for bioanalytical application using supercritical fluid chromatography, Dina Aboushady, Rasha S. Hanafi, Maria K. Parr Journal of Chromatography A, Volume 1676, 2 August 2022, https://doi.org/10.1016/j.chroma.2022.4632

2021

Journal 2021

Aboushady, D., Rasheed, S. S.,Herrmann, J.,Maher, A.,El-Hossary, E. M.,Ibrahim, E. S.,Abadi, A. H.,Engel, M.,Muller, R.,Abdel-Halim, M.,Hamed, M. M., Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents. Bioorg Chem, 2021. 117: p. 105422.DOI: 10.1016/j.bioorg.2021.105422.Aboushady, D., Rasheed, S. S.,Herrmann, J.,Maher, A.,El-Hossary, E. M.,Ibrahim, E. S.,Abadi, A. H.,Engel, M.,Muller, R.,Abdel-Halim, M.,Hamed, M. M., Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents. Bioorg Chem, 2021. 117: p. 105422.DOI: 10.1016/j.bioorg.2021.105422.

2020

Journal 2020

Quality-by-Design is a Tool for Quality Assurance in the Assessment of Enantioseparation of a Model Active Pharmaceutical Ingredient. Dina Aboushady, Maria Kristina Parr, Rasha S. Hanaﬁ. Pharmaceuticals, Special Issue Analytical Techniques in the Pharmaceutical Sciences, Volume 13, Issue 11, 2020 DOI: 10.3390/ph13110364)

2019

Conference 2019

Exploring the design space for enantiomeric resolution of terbutaline drug and its sulfate conjugate metabolites using design of experiment approach.D. abou-shady, R.S. Hanafi, M.K. Parr. 48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques University of Milano-Bicocca, Milan, Italy, June 2019, Poster 424

Dr. Liza Samir Botros

Email: liza.samir@guc.edu.eg
Office: B7.206

Biography

She is a post-doctoral fellow in the Pharmaceutical chemistry department in the Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). She acquired her PhD in 2021 and her M. Sc. in 2017 from the German University in Cairo in Pharmaceutical and Analytical chemistry. She received her B.Sc. degree from the German University in Cairo in 2015.

She has been teaching theoretical and practical courses in the Pharmaceutical Chemistry department since 2015, including, drug design, inorganic chemistry and physical chemitry. Besides teaching and research, she is also a member of some administrative committees in the GUC including advising and mentoring committees.

Research Interests

Pharmaceutical and biomedical analysis -Spectroscopic and chromatographic techniques - Quality-by-Design concepts- Development of analytical methods- Drug design and molecular modeling

Publications

2023

Journal 2023

"Determination of Capecitabine and its Metabolites in Plasma of Egyptian Colorectal Cancer Patients". Shamseldin, S.; Botros, L.S.; Salem, S.E.; Abdel-Maksoud, S.; Gad, M.Z.; Hanafi, R.S*. Analytica 2023, 4, 397–414. https://doi.org/10.3390/analytica4040029

2022

Journal 2022

Liza Samir; Rasha Hanafi*; Sami El Deeb*; Hilde Spahn-Langguth.UHPLC Enantiomer Resolution for the α/β-Adrenoceptor Antagonist R/S-Carvedilol and Its Major Active Metabolites on Chiralpak IB N-5. Molecules 2022, 27, 4998 (Special Issue: Advances in Chiral Separations) https:// doi.org/10.3390/molecules27154998

2021

Journal 2021

Zlotos, D. P.; Abdelmalek, C.; Botros, L.; Banoub, M.; Mandour, Y.; Breitinger, U.; Breitinger, H-G; El Nady, A.; Sotriffer, C.; Villmann , C. ; Jensen, A.; Holzgrabe, U. C-2 Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. Journal of Natural Products, 26;84(2):382-394. doi: 10.1021/acs.jnatprod.0c01030

Dr. Reem Ahmed Wagdy

Email: reem.ahmed-afifi@guc.edu.eg
Office: B1.225

Biography

Reem Wagdy is a Post-Doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). Reem received her B.Sc. degree in 2014 from the faculty of Pharmacy and Biotechnology, GUC and acquired her M. Sc. in 2016 from the German University in Cairo in the field of Pharmaceutical chemistry. In 2021, she was awarded PhD degree in medicinal chemistry from the German University in Cairo (GUC) where part of the PhD was done in Saarland University, Germany and the other part was achieved in the GUC. She has been teaching theoretical and practical courses in the Pharmaceutical Chemistry department. In addition to, teaching and research, she is also a member of some administrative committees in the GUC including advising and mentoring committees.

Research Interests

• In her PhD, she designed and developed novel Mur enzymes inhibitors as antibacterial agents in an attempt to overcome the major obstacle of bacterial resistance.

• In her M.Sc, mainly targeted the synthesis of Novel Quinazoline Derivatives evaluated as potential anticancer agents selectively targeting the blockade of NF-κB pathway.

2023

Journal 2023

Wagdy, R. A.; Abutaleb, N. S.; Fathalla, R. K.; Elgammal, Y.; Weck, S.; Pal, R.; Fischer, P. D.; Ducho, C.; Abadi, A. H.; N Seleem, M.; Engel, M.; Abdel-Halim, M. Discovery of 1,2-Diaryl-3-Oxopyrazolidin-4-Carboxamides as a New Class of MurA Enzyme Inhibitors and Characterization of Their Antibacterial Activity. European Journal of Medicinal Chemistry 2023, 261, 115789. https://doi.org/10.1016/j.ejmech.2023.115789.

2022

Journal 2022	Darwish, S. S.; Chen, P.-J.; Hamed, M. M.; Wagdy, R. A.; Chen, S.-H.; Abadi, A. H.; Abdel-Halim, M.; Hwang, T.-L.; Engel, M. Development of (4-Phenylamino)Quinazoline Alkylthiourea Derivatives as Novel NF-ΚB Inhibitors. Pharmaceuticals 2022, 15 (7), 778. https://doi.org/10.3390/ph15070778.
Journal 2022	Wagdy, R. A.; Chen, P.-J.; Hamed, M. M.; Darwish, S. S.; Chen, S.-H.; Abadi, A. H.; Abdel-Halim, M.; Hwang, T.-L.; Engel, M. From EGFR Kinase Inhibitors to Anti-Inflammatory Drugs: Optimization and Biological Evaluation of (4-(Phenylamino)Quinazolinyl)-Phenylthiourea Derivatives as Novel NF-ΚB Inhibitors. Bioorg. Chem. 2022, 127, 105977. https://doi.org/10.1016/j.bioorg.2022.105977.

Dr. Hend Abdalla Zaghloul Khalifa

Email: hend.zaghloul@guc.edu.eg
Office: B1.205

Biography

Dr. Hend is a post-doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo (GUC). She received her B.Sc. degree from the faculty of Pharmacy and Biotechnology at the GUC in 2014. She then pursued an academic career, where she acquired her MSc and PhD degrees in the field of Pharmaceutical Chemistry from the GUC in 2017 and 2021. Part of her PhD practical work was accomplished at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) in Saarbrücken, Germany which specializes in the development of novel anti-infectives.

She has been teaching theoretical and practical courses in the Pharmaceutical Chemistry department since 2015 as well as the Pharmaceutical Drug Development elective summer course in the GUC Berlin campus in the years 2017, 2018 and 2019. In addition to her academic path, she is also a member of the advising administrative committee.

Research Interests

• Medicinal Chemistry – Computer-Aided Drug Design – Antibacterial Research

• PhD work was specialized in the field of anti-bacterial and mycobacterial drug development.

• MSc work focused on the design and synthesis of novel thienopyrimidines as phosphodiesterase inhibitors and their evaluation as anticancer agents.

2024

Journal 2024	Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour YM, Abadi AH, Engel M, Müller R, Hirsch AKH, Abdel-Halim M, Hamed MM. “Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.” Arch Pharm (Weinheim). 2024 Feb 2:e2300656. doi: 10.1002/ardp.202300656. Online ahead of print.
Journal 2024	Shawky MM, Abdallah M, Khalifa H, Aboushady Y, Abadi AH, Engel M, Abdel-Halim M. “Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors.” Bioorg Chem. 2024 Apr;145:107235. doi: 10.1016/j.bioorg.2024.107235. Epub 2024 Feb 20.
Journal 2024	Aboelfotouh HG, Abdallah M, Khalifa H, Aboushady Y, Abadi AH, Engel M, Abdel-Halim M.“N1 -Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents.” Arch Pharm (Weinheim). 2024 Mar 13:e2400020. doi: 10.1002/ardp.202400020. Online ahead of print.

Dr. Donia Mohamed Eyad Abul Hagag Hafez

Email: Donia.eyad@guc.edu.eg
Office: B1.203

Biography

Donia Eyad is a post-doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). Donia received her B.Sc. degree in 2012 from the faculty of Pharmacy and Biotechnology, GUC and acquired her M.Sc. in 2017 from the GUC in the field of Pharmaceutical Chemistry. In 2021, she was awarded PhD degree in medicinal chemistry from GUC. She taught practical course in Pharmaceutical Biology I department, practical and theoretical courses in Pharmaceutical Technology II and III department, theoretical and practical courses in Instrumental analysis I , practical course in analytical chemistry I , practical and theoretical courses in Pharmaceutical Chemistry I department and practical and theoretical courses in Drug Design department. In addition to teaching and research she is also a member of advising and mentoring commitees in the GUC.

Research Interests

1- Medicinal chemistry and computer aided drug design.

2- In her PhD, she focused on the synthesis of multi-target directing ligands for treatment of Alzheimer’s disease. Many techniques were used in this work including column chromatography, microwave, computational methods ( such as docking experiments) , high performance liquid chromatography and calculation of different physicochemical properties of those compounds.

3- In her M.Sc., she mainly targeted the synthesis of novel thiazolidine derivatives as potent selective pro-apoptotic agents.

2023

Journal 2023

Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark & Ashraf H. Abadi (2023) Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease, Journal of Enzyme Inhibition and Medicinal Chemistry, 38:1, DOI: 10.1080/14756366.2023.2175821

2021

Journal 2021

Hafez DE, Hafez E, Eddiasty I, Shih SP, Chien LC, Hong YJ, Lin HY, Keeton AB, Piazza GA, Abdel-Halim M, Abadi AH. Novel thiazolidine derivatives as potent selective pro-apoptotic agents. Bioorg Chem. 2021 Sep;114:105143. doi: 10.1016/j.bioorg.2021.105143. Epub 2021 Jul 7. PMID: 34328854.

Dr. Islam Tariq Eddiasty

Email: Islam.Eddiasty@guc.edu.eg
Office: B5.127

Biography

Islam Eddiasty is a post-doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). He received his Bachelor degree in Pharmaceutical Sciences from the faculty of Pharmacy Ain Shams university and acquired his master degree from the faculty of pharmacy in the GUC in the speciality of Pharmaceutical Chemistry for his work on the solubility modelling comprising Baclofen and Baclofen derivatives. He was awarded his PhD degree in medicinal chemistry from GUC for his work on Database mining in search for various PDE inhibitors in addition to poteintial SARS CoV-2 inhibitors. He was involved in the development of the practical courses for physical chemistry, Phramaceutical Chemistry, Drug Design in addition to establishing the Drug Design Lab in the GUC. In addition, he was involved in the delievery of course of Drug Design, Pharmaceutical chemistry, General and inorganic chemistry, Pharmaceutical technology, Phytochemistry and Chemistry for Engineering and premaster courses for the post graduate students. In addition to teaching and research Heis also a founding member in the mentoring committee and exam control room committee, in addition to being currently the faculty website editor.

Research Interests

Computer aided drug design including working with QSAR models, pharmacophore models, Docking protocols in addition to special interest in Molecular mechanics models, protein modelling and ADME properties.

2021

Journal 2021

2013

Journal 2013

Anti-inflammatory and cytotoxic activity of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera Handoussa H, Hanafi R, Eddiasty I, El-Gendy M, El Khatib A, Linscheid M, Mahran L, Ayoub N Journal of Functional Foods, 2013 .5(3):1204-1216.

Dr. Magy Maged Herz

Email: magy.maged@guc.edu.eg
Office: B7.207

Biography

Magy is an assistant lecturer and a post-doctoral fellow in the Pharmaceutical Chemistry department in the Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). She earned her B.Sc. from the GUC in 2014. She obtained her M.Sc. in 2017 and her PhD in 2022 from the GUC in Pharmaceutical Chemistry. She has been teaching theoretical and practical courses of Analytical Chemistry since 2014. She is also a member of the mentoring and advising committees.

Research Interests

Pharmaceutical analysis, Chromatography, Quality-by-Design, Design of experiments, Lipidomics

2023

Journal 2023	Herz, M.M.; Gad, M.Z.; Hanafi, R.S. Development and Validation of a Bioanalytical Method for the Quantification of Nitrated Fatty Acids in Plasma Using LC-MS/MS: Application to Cardiovascular Patients. Separations 2023, 10, 87. https://doi.org/10.3390/separations10020087
Conference 2023	Development and Validation of a Bioanalytical Method for Quantification of Nitrated Fatty Acids in Plasma of Cardiovascular Patients by LC-MS/MS. M. Herz, M. Gad, R. Hanafi. HPLC2023, 51st international symposium on High Performance Liquid Chromatography and related techniques, June 2023, Düsseldorf, Germany. Supported by the Alexander von Humboldt foundation..
Journal 2023	Adel Ehab Ibrahim#, Nesrine Abdelrehim El Gohary#, Dina Aboushady, Liza Samir, Shereen Ekram Abdel Karim, Magy Herz, Baher I. Salman, Ahmed Al-Harrasi, Rasha Hanafi, Sami El Deeb. "Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review." Journal of Chromatography A.* Volume 1706, 13 September 2023, 464214. https://doi.org/10.1016/j.chroma.2023.464214.

2019

Journal 2019

Nadine George; Magy Herz; Hassan Aboul-Enein; Lamia Shihata; Rasha Hanafi, Surface Design of Enantiomeric HPLC Separation on Vancomycin and Teicoplanin-Based Stationary Phases, a Tool for Chiral Recognition of Model β-Blockers. Journal of Chromatographic Sciences. 2019, 57, 485–494, doi:10.1093/chromsci/bmz018.

2018

Conference 2018

Quality by Design Approach for HPLC Method development on Vancomycin Based Stationary Phase. Magy M. Herz, Rasha S. Hanafi, Lamia A. Shehata, Hassan Y. Aboul-Enein. ISC 2018, 32nd International Symposium on Chromatography, Abstract PS-05-13, 23-27 September 2018, Cannes- Mandelieu, France.

Dr. Mirna Victor Azmy Ayad

Email: Mirna.Ayad@guc.edu.eg
Office: B1.203

Email: youssef.helmi@guc.edu.eg
Office: B1.203

Biography

Dr. Youssef Helmi is a post-doctoral fellow in the pharmaceutical chemistry department, faculty of pharmacy and biotechnology at the German University in Cairo (GUC). Dr. Youssef received his B.Sc. degree in 2016 from the faculty of pharmacy and biotechnology, German University in Cairo and acquired his M.Sc. degree in 2019 from the German University in Cairo in the field of pharmaceutical chemistry. In 2023, Dr. Youssef was awarded PhD degree in pharmaceutical chemistry from the German University in Cairo where part of the PhD practical work was done in Freiburg University, Germany and the other part was achieved in the GUC. Since 2016, Dr. Youssef taught different courses in the pharmaceutical chemistry department including organic chemistry theoretical and practical courses, Pharmaceutical Chemistry I,II, III and IV theoretical and practical courses, analytical chemistry practical course and chemistry for engineering practical course, also he joined GUC Berlin campus during winter semester 2019. In addition to, teaching and research, he is also a member of some administrative committees in the GUC including advising and mentoring committees.

Research Interests

Organic and medicinal chemistry.

• M.Sc. work included synthesis of Novel bivalent Daclatasvir derivatives as anti HCV.

• PhD work included synthesis of melatonin-vorinostat drug conjugates and sirtuins inhibitors as potential anti-cancer agents.

2023

Journal 2023

Youssef Y. Helmi, Niklas Papenkordt, Georg Rennar, Florence Gbahou, Ahmed K. El-Hady, Nedjma Labani, Karin Schmidtkunz, Stefan Boettcher, Ralf Jockers, Mohammad Abdel-Halim, Manfred Jung and Darius P. Zlotos. Melatonin-Vorinostat Hybrid Ligands Show Higher HDAC and Cancer Cell Growth Inhibition than Vorinostat. Archiv der Pharmazie, (2023).

2020

Journal 2020

Symmetric benzidine derivatives as anti-HCV agents: insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates; Abdel Karim, Shereen E.; Youssef, Youssef H.; Abdel-Halim, Mohammad; Frakolaki, Efseveia; Vassilaki, Niki; Zoidis, Grigoris; Ahmed, Nermin S.; Abadi, Ashraf H. Bioorganic Chemistry, (2020).

Dr. Marian Magdy Ramsis

Email: Marian.Ramsis@guc.edu.eg
Office: B5.228

Email: Heba.Elnakib@guc.edu.eg
Office: B1.225

Biography

Heba ElNakib is a post-doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology at the German University in Cairo (GUC). Heba received her B.Sc. degree in 2016 from the faculty of Pharmacy and Biotechnology, GUC and acquired her M.Sc. in 2018 from the GUC in the field of Pharmaceutical Chemistry. During her M.Sc. journey she received DAAD-BMBF fund to complete part of her practical work in Technische Universität Dresden. In 2023, she was awarded PhD degree in medicinal chemistry from GUC. She has been teaching various theoretical and practical courses in the Pharmaceutical Chemistry department since 2016 such as :Instrumenal analysis, Physical chemistry and Chemistry for Engineering.Besides teaching and research, she is also a member of some administrative committees in the GUC including advising and mentoring committees.

Research Interests

Medicinal Chemistry – Computer-Aided Drug Design -Chromatography – Cancer Reseach- Alzheimer's Disease Research

2023

Journal 2023	Ahmed, N. S., El-Nakib, H. E., Ramsis, M. M., Albably, N. O., Wober, J., Weigand, J. J., Schwedtmann, K., Zierau, O., & Abadi, A. H. (2023). Structure-Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents. ACS omega, 8(29), 25903–25923. https://doi.org/10.1021/acsomega.3c01682.
Journal 2023	Elbagoury, R. M.; Shenouda, M. A.; Elnakib, H. E.; Wober, J.; Abadi, A. H.; Ahmed, N. S. Design, Synthesis, and Metabolite Identification of Tamoxifen Esterase-Activatable Prodrugs. Bioorg. Chem. 2023, 131, 106303.

2021

Journal 2021

Elnakib, H. E., Ramsis, M. M., Albably, N. O., Vector, M. A., Weigand, J. J., Schwedtmann, K., Wober, J., Zierau, O., Vollmer, G., Abadi, A. H., & Ahmed, N. S. (2021). Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs. International journal of molecular sciences, 22(22), 12575. https://doi.org/10.3390/ijms222212575.

Dr. Michael Emad George

Email: Michael.Emad@guc.edu.eg
Office: B1.203

Email: Reham.alajami@guc.edu.eg
Office: B1.205

Email: Sherif.Nasser@guc.edu.eg
Office: B1.203

Email: mennatallah.abdallah@guc.edu.eg
Office: B1.220

Email: youssef.aboushady@guc.edu.eg
Office: B1.205

Email: nouran.albably@guc.edu.eg
Office: B1.205

Biography

I am an assistant lecturer and post-doctoral fellow in the Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC). I received my B.Sc. degree from the faculty of Pharmacy and Biotechnology at the GUC in 2017. I pursued an academic career, where I acquired my M.Sc. in 2019 in the field of Pharmaceutical Chemistry from the German University in Cairo. In, 2024, I acquired the PhD degree in the field of Pharmaceutical Chemistry from the German University in Cairo. I have been teaching theoretical and practical of Pharmaceutical Chemistry III, Pharmaceutical Chemistry IV, Drug design and the theoretical of Inorganics pharmaceutical elective courses since 2017. Moreover, I am a member of the advising and mentoring administrative committees.

Research Interests

During the PhD program, she concentrated on the design and synthesis of novel Ridaifen analogues, exploring their potential for proteasomal inhibition and anti-cancer activity.

During the M.Sc. program, the focus was on synthesizing novel tamoxifen analogues and evaluating their potential as inhibitors of breast cancer. The aim was to achieve these anticancer effects while also providing positive estrogenic benefits for bone and cardiovascular health, without increasing the risk of endometrial cancer.

2023

Journal 2023

Ahmed, N. S., El-Nakib, H. E., Ramsis, M. M., Albably, N. O., Wober, J., Weigand, J. J., Schwedtmann, K., Zierau, O., & Abadi, A. H. (2023). Structure-Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents. ACS omega, 8(29), 25903–25923. https://doi.org/10.1021/acsomega.3c01682.

2021

Journal 2021

Elnakib, H. E., Ramsis, M. M., Albably, N. O., Vector, M. A., Weigand, J. J., Schwedtmann, K., Wober, J., Zierau, O., Vollmer, G., Abadi, A. H., & Ahmed, N. S. (2021). Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs. International journal of molecular sciences, 22(22), 12575. https://doi.org/10.3390/ijms222212575.

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Head of Pharmaceutical Chemistry Department
Prof. Dr. Ashraf Abadi