Biography | Prof. Samar got her Bachelor in 1990 from the Faculty of Pharmacy, Cairo University with general grade “Excellent with Honor- Top Ranked”. She earned her MSc then Ph.D. Degree in Pharmaceutics and Industrial Pharmacy from Faculty of Pharmacy, Cairo University. In 2001, she was assigned as a lecturer in the Pharmaceutics and Industrial Pharmacy Department at Cairo University. In 2002, she moved to the Faculty of Pharmacy, Ain Shams University and established the first nanotechnology research group; assist in building the faculty until she became a professor and the quality assurance manager. Prof. Samar has more than 30 years of experience in teaching and preparing theoretical and practical courses for the undergraduate and post graduate students at GUC, Cairo University, Ain Shams University and Misr International University (MIU). Prof. Samar Joined the GUC in 2011 as a part time staff and quality consultant and as a full time staff in 2013 to share her experience in teaching, research, quality assurance and accreditation. She is currently the head of Pharmaceutical Technology Department and leader of its nanotechnology research group, the Vice Dean for Academic Affairs and the Vice Presidency for the Quality Assurance and Accreditation at the German University in Cairo (GUC). Prof. Samar has got several awards for her publications and has been a reviewer of patents and research papers in several international journals. Prof. Samar supervises more than 50 M.Sc. and Ph.D. theses at the Faculty of pharmacy- GUC and Faculty of pharmacy- Ain Shams University for Post Graduate Students from different Countries, Universities and research institutes. She published more than 60 international journal publications and more than 70 conference abstracts, with an h-index of 31 and more than 3500 citations. Prof. Samar is an international speaker and consultant for the development of the health care team in the Middle East and Member in several scientific societies. She also consults, reviews educational programs and coordinates workshops in the field of Quality Assurance and accreditation. | Research Interests | Her main research interest is application of nanotechnology for drug delivery through different routes (oral, nasal, ophthalmic and transdermal). Vesicular drug delivery systems have attracted her attention since she started her PhD. Drug targeting to different organs (brain, liver and lung) as well has been a major research concern. Her ongoing research can be divided into the following clusters:
1- Passive and active targeting by Nano-carriers
• Studying the role of NP physicochemical properties, intracellular localization and release profiles, serum proteins and NP opsonization in cancer targeting
2- Transdermal drug delivery
• Determination of the applicability of transdermal NPs in cancer targeting via the enhanced permeation and retention (EPR) effect |
Publications2023| Journal 2023 | Enhancement of mitochondrial function using NO releasing nanoparticles; a potential approach for therapy of Alzheimer’s diseases Mirna Samir, Reham M Abdelkader, Maryam Shetab Boushehri, Samar Mansour, Alf Lamprecht, Salma N Tammam 2023/1/11 European Journal of Pharmaceutics and Biopharmaceutics | | Journal 2023 | "The Potential Role of Nanomedicine in the Treatment of Channelopathies: A Closer Look at Gene and Protein Therapy " has been approved for publication in "Current Pharmaceutical Design" journal. Hans-Georg Breitinger ; Monica Sakla; Samar Mansour; Ulrike Breitinger and Salma Tammam |
2022Journal 2022 | Aya A Ezzat; Salma N Tammam; Rasha S Hanafi; Omar Rashad; Aya Osama; Eman Abdelnaby; Sameh Magdeldin; Samar Mansour. “Different Serum, Different Protein Corona! The Impact of the Serum Source on Cellular Targeting of Folic Acid-Modified Chitosan-Based Nanoparticles”. Molecular pharmaceutics 2022, https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00108 | | Journal 2022 | Drugless nanoparticles tune-up an array of intertwined pathways contributing to immune checkpoint signaling and metabolic reprogramming in triple-negative breast cancer Asmaa Ramzy, Sara ElSafy, Hisham A Elshoky, Aya Soliman, Rana A Youness, Samar Mansour, Aya Sebak Journal of Biomedical Materials- 2022/12/2 | | Journal 2022 | The skin delivery of Tofacitinib citrate using transethosomes and hybridized ethosomes/nanostructured lipid carriers for vitiligo therapy: Dermatopharmacokinetics and in vivo assays Heba Hesham, Mai Rady, Rania Hathout, Mohamed Abd ElHalim and Samar Mansour Int. Journal of Pharmaceutics (November 2022) | | Journal 2022 | "Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria." Fangary, Suzan, Mohammad Abdel-Halim, Reem K. Fathalla, Raghda Hassan, Noha Farag, Matthias Engel, Samar Mansour, and Salma N. Tammam. Molecular Pharmaceutics (2022). | | Journal 2022 | “The other side to the use of active targeting ligands; the case of folic acid in the targeting of breast cancer” Lama A Helmy, Mohammed Abdel-Halim, Raghda Hassan, Aya Sebak, Haithem AM Farghali, Samar Mansour, Salma N Tammam. Colloids and Surfaces B: Biointerfaces, volume 211, 2022 |
2021| Funded Project 2021 | STDF funded Project ID: 30133 “Biodegradabl e Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Advanced Fibrosis & Cirrhosis; A Novel Multi Target Approach” Main PI: Prof. Samar Mansour (2021- 2024) |
2020Journal 2020 | Azzam, M.; El Safy, S.; Abdelgelil, S.A.; Weiskirchen, R.; Asimakopoulou, A.; de Lorenzi, F.; Lammers, T.; Mansour, S.; Tammam, S. Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers. Pharmaceutics 2020, 12, 590 | Journal 2020 | Ramadan, S., Tammam, S. N., Shetab Boushehri, M. A., Breitinger, H. G., Breitinger, U., Mansour, S., & Lamprecht, A. (2020). Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; a potential approach for the treatment of channelopathies. International journal of biological macromolecules, 153, 1080–1089. | Journal 2020 | El-Safy, S., Tammam, S. N., Abdel-Halim, M., Ali, M. E., Youshia, J., Shetab Boushehri, M. A., Lamprecht, A., & Mansour, S. (2020). Collagenase loaded chitosan nanoparticles for digestion of the collagenous scar in liver fibrosis: The effect of chitosan intrinsic collagen binding on the success of targeting. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 148, 54–66. | Journal 2020 | Nasr S, Rady M, Sebak A, et al. A Naturally Derived Carrier for Photodynamic Treatment of Squamous Cell Carcinoma: In Vitro and In Vivo Models. Pharmaceutics. 2020;12(6):494. | | Journal 2020 | Saad, E.M., El Gohary, N.A., El-Shenawy, B.M., Handoussa, H., Klingner, A., Elwi, M., Hamed, Y., Khalil, I.S., El Nashar, R.M. and Mizaikoff, B. Fabrication of Magnetic Molecularly Imprinted Beaded Fibers for Rosmarinic Acid. Nanomaterials 2020, 10(8), p.1478. |
2018Journal 2018 | In vitro transdermal delivery of sesamol using oleic acid modified gelatin nanoparticles as a potential breast cancer medication. Journal of Drug Delivery Science and Technology. ElMasry, S., Hathout, R., Mansour, S (2018).Accepted Manuscript | Journal 2018 | Exploring gelatin nanoparticles as novel nanocarriers for Timolol Maleate: Augmented in-vivo efficacy and safe histological profile. Shokry, M., Hathout, R. M., & Mansour, S. (2018). International journal of pharmaceutics, 545(1-2), 229-239. | Journal 2018 | Examining Insulin Adsorption onto Mesoporous Silica Microparticles for Oral Delivery. Eilleia, S. Y., Soliman, M. E., Niedermayer, S., Schmidt, A., Mansour, S., & Geneidi, A. S. (2018). Current drug delivery, 15(4), 541-553. | Journal 2018 | Novel technique of insulin loading into porous carriers for oral delivery. Eilleia, S. Y., Soliman, M. E., Mansour, S., & Geneidi, A. S. (2018). Asian Journal of Pharmaceutical Sciences. |
2017Journal 2017 | Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model. Barakat, S. S., Nasr, M., Ahmed, R. F., Badawy, S. S., & Mansour, S. (2017). Scientific Reports, 7(1), 9910. | Journal 2017 | Novel polyglycerol-dioleate based cubosomal dispersion with tailored physical characteristics for controlled delivery of ondansetron. Mansour, M., Kamel, A. O., Mansour, S., & Mortada, N. D. (2017). Colloids and Surfaces B: Biointerfaces, 156, 44-54. | Journal 2017 | A novel serum-stable liver targeted cytotoxic system using valerate-conjugated chitosan nanoparticles surface decorated with glycyrrhizin. El-Marakby, E. M., Hathout, R. M., Taha, I., Mansour, S., & Mortada, N. D. (2017). International journal of pharmaceutics, 525(1), 123-138. | Journal 2017 | Nanoethosomes for transdermal delivery of tropisetron HCl: multi-factorial predictive modeling, characterization, and ex vivo skin permeation. Abdel Messih, H. A., Ishak, R. A., Geneidi, A. S., & Mansour, S. (2017). Drug development and industrial pharmacy, 43(6), 958-971. | Journal 2017 | Studying the effect of physically‐adsorbed coating polymers on the cytotoxic activity of optimized bisdemethoxycurcumin loaded‐PLGA nanoparticles. Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2017). Journal of Biomedical Materials Research Part A, 105(5), 1433-1445. | Journal 2017 | Surface functionalization of methotrexate-loaded chitosan nanoparticles with hyaluronic acid/human serum albumin: Comparative characterization and in vitro cytotoxicity.Hashad, R. A., Ishak, R. A., Geneidi, A. S., & Mansour, S. (2017). International journal of pharmaceutics, 522(1-2), 128-136. | Journal 2017 | Optimizing novel penetration enhancing hybridized vesicles for augmenting the in-vivo effect of an anti-glaucoma drug. Naguib, S. S., Hathout, R. M., & Mansour, S. (2017). Drug delivery, 24(1), 99-108. |
2016Journal 2016 | Composite chitosan-transfersomal vesicles for improved transnasal permeation and bioavailability of verapamil. Mouez, M. A., Nasr, M., Abdel-Mottaleb, M., Geneidi, A. S., & Mansour, S. (2016). International journal of biological macromolecules, 93, 591-599. | Journal 2016 | Methotrexate loading in chitosan nanoparticles at a novel pH: Response surface modeling, optimization and characterization.Hashad, R. A., Ishak, R. A., Geneidi, A. S., & Mansour, S. (2016). International journal of biological macromolecules, 91, 630-639. | Journal 2016 | Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks.Hashad, R. A., Ishak, R. A., Fahmy, S., Mansour, S., & Geneidi, A. S. (2016). . International journal of biological macromolecules, 86, 50-58. | Journal 2016 | Identifying lipidic emulsomes for improved oxcarbazepine brain targeting: In vitro and rat in vivo studies.El-Zaafarany, G. M., Soliman, M. E., Mansour, S., & Awad, G. A. (2016). International journal of pharmaceutics, 503(1-2), 127-140. | Journal 2016 | Exploring the use of nanocarrier systems to deliver the magical molecule; curcumin and its derivatives. Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2016). Journal of Controlled Release, 225, 1-30. | Journal 2016 | Bisdemethoxycurcumin loaded polymeric mixed micelles as potential anti-cancer remedy: preparation, optimization and cytotoxic evaluation in a HepG-2 cell model. Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2016). Journal of Molecular Liquids, 214, 162-170. | Journal 2016 | Optimized Moxifloxacin Nanoliposomes with Enhanced Stability.Hamed, A, Osman, R., Mansour, S., & Geneidi, A.S. (2016). International Journal of Pharmacy and Pharmaceutical Sciences, 6 (2): 147-169 |
2015Journal 2015 | Preparation and Evaluation of Mucoadhesive Gellan Gum in-Situ Gels for the Ocular Delivery of Carbonic Anhydrase Inhibitor Nanovesicles. Elazreg, R., Soliman, M., Mansour, S., & El Shamy, A. (2015). International Journal of Pharmaceutical Sciences and Research, 6(9), 3761-3774. | Journal 2015 | “Peptide Post Encapsulation Onto Porous Polymeric and Inorganic Microparticles”. Eilleia, S., Soliman, M., Mansour, S. (2015). Thomas Bein Controlled Release Meeting. | Journal 2015 | Quantitative Determination of Insulin Loading Capacity and Release Profile from Porous PLGA Microparticles. Eilleia, S., Soliman, M.E., Mansour, S. & Geneidi, A. (2015). the Egyptian journal of biomedical sciences. |
2014Journal 2014 | Bioavailability enhancement of verapamil HCl via intranasal chitosan microspheres. Mouez, M. A., Zaki, N. M., Mansour, S., & Geneidi, A. S. (2014). European Journal of Pharmaceutical Sciences, 51, 59-66. | Journal 2014 | Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Bshara, H., Osman, R., Mansour, S., & El-Shamy, A. E. H. A. (2014). Carbohydrate polymers, 99, 297-305. |
2013Journal 2013 | Non invasive ventilation versus synchronized intermittent mandatory ventilation with pressure support in weaning of COPD patients: Comparative study. El-Shimy, W.S., Barima, M.A., Abo El-Magd, G.H. & Mansour, S. (2013). Egyptian Journal of Chest Diseases and Tuberculosis. 62. 159-166. | Journal 2013 | Hydrophilic versus hydrophobic porogens for engineering of poly (lactide-co-glycolide) microparticles containing risedronate sodium.Nasr, M., Awad, G. A., Mansour, S., Al Shamy, A., & Mortada, N. D. (2013). Pharmaceutical development and technology, 18(5), 1078-1088. |
2012Journal 2012 | Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide. Youshia, J., Kamel, A. O., El Shamy, A., & Mansour, S. (2012). International journal of nanomedicine, 7, 2483. |
2011Journal 2011 | Different modalities of NaCl osmogen in biodegradable microspheres for bone deposition of risedronate sodium by alveolar targeting. Nasr, M., Awad, G. A., Mansour, S., Taha, I., Al Shamy, A., & Mortada, N. D. (2011). European Journal of Pharmaceutics and Biopharmaceutics, 79(3), 601-611. | Journal 2011 | A reliable predictive factorial model for entrapment optimization of a sodium bisphosphonate into biodegradable microspheres. Nasr, M., Awad, G. A., Mansour, S., Al Shamy, A., & Mortada, N. D. (2011). Journal of pharmaceutical sciences, 100(2), 612-621. | Journal 2011 | Visualization, dermatopharmacokinetic analysis and monitoring the conformational effects of a microemulsion formulation in the skin stratum corneum. Hathout, R. M., Mansour, S., Geneidi, A. S., & Mortada, N. D. (2011). Journal of colloid and interface science, 354(1), 124-130. |
2010Journal 2010 | Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Hathout, R. M., Mansour, S., Mortada, N. D., Geneidi, A. S., & Guy, R. H. (2010). Molecular pharmaceutics, 7(4), 1266-1273. | Journal 2010 | Microemulsion formulations for the transdermal delivery of testosterone. Hathout, R. M., Woodman, T. J., Mansour, S., Mortada, N. D., Geneidi, A. S., & Guy, R. H. (2010). European Journal of Pharmaceutical Sciences, 40(3), 188-196. | Journal 2010 | Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. El Zaafarany, G.M., Awad, G.A.S., Mansour, S. & Mortada, N.M. (2010). International Journal of Pharmaceutics, 397(1-2), 164-172. |
2009Journal 2009 | Ionotropically emulsion gelled polysaccharides beads: preparation, in vitro and in vivo evaluation. Elmowafy, E. M., Awad, G. A., Mansour, S., & El-Shamy, A. E. H. A. (2009). carbohydrate Polymers, 75(1), 135-142. |
2008Journal 2008 | Release mechanisms behind polysaccharides-based famotidine controlled release matrix tablets. Elmowafy, E. M., Awad, G. A., Mansour, S., & El-Shamy, A. E. H. A. (2008). AAPS PharmSciTech, 9(4), 1230-1239. | Journal 2008 | Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. Nasr, M., Mansour, S., Mortada, N. D., & Elshamy, A. A. (2008). Journal of Microencapsulation, 25(7), 499-512. | Journal 2008 | Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation. Nasr, M., Mansour, S., Mortada, N. D., & El Shamy, A. A. (2008). AAPS PharmSciTech, 9(1), 154-162. | Journal 2008 | Ocular poloxamer-based ciprofloxacin hydrochloride in situ forming gels. Mansour, M., Mansour, S., Mortada, N. D., & Abd ElHady, S. S. (2008). Drug development and industrial pharmacy, 34(7), 744-752. |
2007Journal 2007 | Effect of metal type and content on mechanical, electrical and free-volume properties of styrenated polyesters. Mansour, S., Gomaa, E & Hanna, I.K. (2007). Journal of Materials Science. 42. 8473-8480. | Journal 2007 | Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies.Hathout, R. M., Mansour, S., Mortada, N. D., & Guinedi, A. S. (2007). AAPS pharmscitech, 8(1), E1-E12. |
2005Journal 2005 | Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide. Guinedi, A. S., Mortada, N. D., Mansour, S., & Hathout, R. M. (2005). International journal of pharmaceutics, 306(1-2), 71-82. |
2003Journal 2003 | Depolymerization of Poly(ethylene terephthalate) Waste Using 1,4-Butanediol and Triethylene Glycol. Mansour, S., Ikladious, N.E. (2003). Polymer Testing. 21. 497-505. |
2002Journal 2002 | Electrical and mechanical properties of some polymeric composites. Mansour, S. & Abd-El-Messieh, s. (2002). Journal of Applied Polymer Science. 83. 1167 - 1180. |
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