Biography | Heba Handoussa is Associate Professor of Pharmaceutical Biology at the faculty of Pharmacy and Biotechnology of the German University in Cairo. She earned her PhD from German University in Cairo (GUC), Egypt. She has a considerable experience in undergraduate teaching where she functions as a lecturer of Pharmaceutical Biology since 2013. Main author of several published articles in reputable scientific journals in field of Pharmacy and Reviewer in number of of Scopus and Medline indexed international peer reviewed journals related to the fields of Pharmaceutical Biology and Food Science. In addition to, supervision over 20 Masters and PhD theses. Her research group includes activities related to the applications and bioactivities of the natural products ( medicinal plants, marine yields). Noteworthy, the implementation of new trends of food science, technology and food safety as a foremost interest within the research activities. | Research Interests | Her research focus areas are; plant secondary metabolism analysis and familiarity with multiple mass spectrometers and techniques (i.e. GC/MS, LC/MSn), besides awareness of several spectroscopic techniques to identify, isolate and purify the bioactive phytochemical compounds, having responsibilities in postgraduates studies’ supervision; Bachelor, Masters and PhD theses in the same field, In addition to the main concern which is exploring the different Pharmacological activities behind the isolated phytomedicinals. She has been probing novel bioactive molecules with possible antinflammatory, molecular targeted HCC therapy, anticancer, neuroprotective, antidiabetic and other Pharmacological activities. Besides, the bioactivity of the nutraceuticals and special insights on Integrated Food Science. |
2023| Journal 2023 | "Quinoa and Chia modulate AMPK/ PPAR-ɣ signaling in High-fat diet-induced obesity rats model” Nayra Helmy Omran, Alshaymaa A.Z. El-Bahy, Heba Tallah Ashraf Hosny, Heba Handoussa Brazilian Journal of Pharmacognosy, 33, 583–594, April 2023 | | Journal 2023 | “Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study” Reham Ahmed Wagdy,Reham M. Abdel-Kader, Ahmed H. El-Khatib, Michael W. Linscheid, Heba Handoussa; Nabila Hamdi, BMC Complementary Medicine and Therapies, 23,165, May 2023 | | Journal 2023 | Noha H. Atta, Heba Handoussa, Iris Klaiber, Bernd Hitzmann, Rasha S. Hanafi. "Chemometric Approach for Profiling of Metabolites of Potential Antioxidant Activity in Apiaceae Species Based on LC-PDA-ESI-MS/MS and FT-NIR". Separations 2023, 10, 347. https://doi.org/10.3390/separations10060347 | | Journal 2023 | Ammar, Mai.K., Hanafi, Rasha.S., Choucry, Mouchira.A. Heba Handoussa "Structural, functional, nutritional composition and analytical profiling of Triticum aestivum L." Applied Biological Chemistry 2023, 66, 48. https://doi.org/10.1186/s13765-023-00804-3. |
2022| Journal 2022 | “Uncoupling Tumor Necrosis Factor-α and Interleukin-10 at Tumor Immune Microenvironment of Breast Cancer through miR-17-5p/MALAT-1/H19 circuit" Raghda Ashraf Soliman, Rana Ahmed Youness, Tamer M Manie, Emad Khallaf, Mona AbdelMohsen, Heba Handoussa, Mohamed Gad, Vol.46, No.3, 2022,769-783, Biocell, 2022 | | Journal 2022 | “Edible seeds with potential anti-obesity impact : A Review” Heba Hosny, Nayra Omran, Heba Handoussa International Journal of Plant Based Pharmaceuticals, January 2022 | | Journal 2022 | “UPLC-PDA-MS/MS Profiling and Healing Activity of Polyphenols Rich Fraction of Alhagi maurorum against Oral Ulcer in Rats” Noha Swilam, Hala El-Zahar, Esther T. Menze, Heba Handoussa, Ahmed K. Osman, Mohamed El-Shazly, Nada M. Mostafa, Plants, Feb. 2022 | | Journal 2022 | “LC-MS-based chemical profiling and in-vivo evaluation of the anti-inflammatory and anti-nociceptive activities of the defatted methanolic extract of Crataegus sinaica fruits” Rehab F. Abdel-Rahman, Ahmed. El-Desoky Heba Handoussa, Meselhy R. Meselhy, Gihan F. Asaad, Sahar El-Mekkawy, Egyptian Journal of Chemistry, April 2022 | | Journal 2022 | “Molecularly Imprinted Solid Phase Extraction Strategy for Quinic Acid “ Megahed SH, Abdel-Halim M, Hefnawy A, Heba Handoussa, Mizaikoff B, El Gohary NA.. Polymers, August 2022 | | Journal 2022 | “Identification and quantitation of ursolic acid in Plectranthus amboinicus extract; molecular docking approach for its antiproliferative potential”. AbdelMohsen, M., Salah, I.A., Heba Handoussa and Mandour, Y., Egyptian Journal of Chemistry March 2022 | | Journal 2022 | “Phytoecdysteroids and anabolic-effect of Atriplex dimorphostegia:”UPLC-PDA-MS/MS profiling, in-silico and in-vivo models” Eman Zaghloul, Heba Handousa, Abdel Nasser B. Singab, Mohey M. Elmazar, Iriny Ayoub, Noha Swilam Plants, 2022 |
2021Journal 2021 | Elshamy S, Abdel Motaal A, Abdel-Halim M, Medhat D, Handoussa H. "Potential neuroprotective activity of Mentha longifolia L. in aluminum chloride-induced rat model of Alzheimer's disease". Journal of Food Biochemistry, DOI:10.1111/jfbc.13644. PMID: 33587299 | | Journal 2021 | Hamed, M.M., Handoussa, H., Hussein, N.H., Eissa, R.A., Abdel-Aal, L.K. and El Tayebi, H.M. "Oleuropin controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology“ Life Sciences, p.119353, https://doi.org/10.1016/j.lfs.2021.119353 | | Journal 2021 | “Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating calcium and MAPKs” Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang. Frontiers in Pharmacology, 2477, 2021 |
2020Journal 2020 | Saad E.M., El Gohary N.A, AbdEl Halim M., Handoussa H., El Nashar R. M. and Mizaikof B. (2020)” Molecularly Imprinted Polymers for Selective Extraction of Rosmarinic Acid from Rosmarinus officinalis L.” J Food Chem. 335, 127644. IF 6.306 | | Journal 2020 | Saad E.M., El Gohary N.A., El-Shenawy B.M., Heba Handoussa H., Klingner A., Elwi M., Hamed Y., Khalil I.S., El Nashar R.M. and Mizaikoff B. (2020) ”Molecularly Imprinted Beaded Fibers for Rosmarinic Acid” J Nanomater. 10(8),1478 IF 4.324 | | Journal 2020 | El-Hossary E, Abdel-Halim M,. Ibrahim E, Pimentel-Elardo SM, Handoussa H, Holzgrabe U, Abdelmohsenn UR. (2020) ” Natural Products Repertoire of the Red Sea” J Mar. Drugs 18, 457. IF 4.379 | | Journal 2020 | Mai K. Ammar, Heba Handoussa, Rasha S. Hanafi, Mohamed El-Shazly & Mohamed Z. Gad. "Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities", Natural Product Research, DOI: 10.1080/14786419.2020.1837817 | | Journal 2020 | Alfaifi , M., Alsayari ,A., Gurusamy ,N., Louis, J., Elbehairi, S. , Venkatesan, K. , Sivakumar Annadurai , Yahya I Asiri , Shati, A. , Kamel, S. , Alboushnak, H., Handoussa, H., Muhsinah, A. , Abdel Motaal, A. (2020)” Analgesic, anti-Inflammatory, cytotoxic activity screening and UPLC-PDA-ESI-MS metabolites determination of bioactive fractions of Kleinia pendula” Molecules, 25(2), p.418. IF 3.267 | | Journal 2020 | Atwa, S., Handoussa, H., Hosny,K., Odenthal, M. and El Tayebi, H., , (2020)” Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma” World Jl of Hepatol (ahead of print) IF 2.77 |
2019Journal 2019 | Thabit, S., Handoussa, H., Roxo, M., El Sayed, N., Cestari de Azevedo, B., Wink, M. (2019) “Evaluation of antioxidant and neuroprotective activities of Cassia fistula (L.) using the Caenorhabditis elegans model” PeerJ (6), p. e5159 | | Journal 2019 | Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS-MS El-Askary, H., Handoussa, H. , Badria, F., El-Khatib, A., Linscheid, M. Abd El Motaal, A. (2019) Rev Bras de Farma, 29 (2), 213-220 | | Journal 2019 | UPLC–ESI-PDA–MSn profiling of phenolics involved in biological activities of the medicinal plant Halocnemum strobilaceum (Pall.) Handoussa, H., AbdAllah, W., Abdel-Mohsen, M. (2019), Iran J Pharm Res, volume 18 (1), p. 422 | | Journal 2019 | Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L. Wagdy, R., A.kader, R., El‐Khatib, A., Linscheid, M., Hamdi, N., Handoussa, H. (2019), J of Food Sci, volume 84 (5), p. 1012-1022 | | Journal 2019 | Ocimum kilimandscharicum L. restores ovarian functions in letrozole-induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin Khaled, N., El-Bahy, A., Radwan, R., Handoussa, H., AbdelMaksoud, S. (2019) J life Sci, volume 232, (1) 116640, 2019 | | Journal 2019 | Thabit, S., Handoussa, H., Roxo, M., Cestari de Azevedo, B., El Sayed, N., Wink, M. (2019) “Styphnolobium japonicum (L.) Schott Fruits Increase Stress Resistance and Exert Antioxidant Properties in Caenorhabditis elegans and Mouse Models“ Molecules, volume 19;24(14). pii: E263 |
2018Journal 2018 | Hosney, H., El Gohary, N., Saad, E., Handoussa, H., El Nashar, R. (2018)” Isolation of Sinapic acid from Broccoli using Molecularly Imprinted Polymers” J Sep Sci Wiley; 41 (5):1164-1172 |
2017Journal 2017 | Handoussa, H., Hanafi, R., El-Khatib, A., Linscheid, M., Mahran, L., Ayoub, N.(2017)” Computer-Assisted HPLC Method Development Using DryLab® for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-qTOF-MSn “Research & Reviews: J Bot Sci | | Journal 2017 | Shaalan, Y., Handoussa, H., Youness, R., Assal, R., El-Khatib, A., Linscheid, M., El Tayebi, H., Abdelaziz, A. (2017)” Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma” Nat Prod Res, 18:1-4 |
2016Journal 2016 | Yasmine Mandour, Handoussa, H., Swilam, N., Hanafi, R., Mahran L. (2016)” Structural docking studies of COX-II inhibitory activity for quercetin metabolites derived from Corchorus Olitorius and Vitis Vinifera”, Inter J Food Prop, 2377-2384 | | Journal 2016 | Farag, M., Handoussa, H., Fekry, F., Wessjohann, L. (2016)” Metabolites profiling in 18 Saudi date palm fruit cultivars and their antioxidant potential via UPLC-qTOF-MS and multivariate data analyses“ Food Funct - Royal Society of Chemistry, volume 7, pages 1077-1086 | | Journal 2016 | Sobeh, M., Peixoto, H., Rola Labib, R., Handoussa, H., Swilam, N., Wink, M., Ayoub, N. (2016) “Identification of phenolic secondary metabolites from Schotia brachypetala Sond. (Fabaceae) and demonstration of their antioxidant activities in Caenorhabditis elegans“ |
2015Book 2015 | Liver Protection By Natural Means” Hepatoprotective agents from Medicinal Plants LAP- LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing is a trademark of: OmniScriptum GmbH & Co. KG Heinrich-Böcking-Str. 6-8, 66121, Saarbrücken, Germany (ISBN 978-3-659-74629-1) Authors: Heba Handoussa, Laila Mahran, Nahla Ayoub |
2014Journal 2014 | Hassaan,Y., Handoussa H., El-Khatib, A., Linscheid, M., El Sayed, N., Ayoub, N. (2014)” Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads“, BioMed Res Inter, Volume 2014 , Article ID 843263 |
2013Journal 2013 | Handoussa, H., Hanafi, R., Eddiasty, I., El-Gendy, M., Linscheid, M., Mahran, L., Ayoub, N. (2013)” In Vitro and In Vivo Anti-Inflammatory and Cytotoxic Capacities of Dietary Phenolics Isolated From Corchorus Olitorius and Vitis Vinifera” J Funct Foods, 5(3):1204-1216 |
2009Journal 2009 | Handoussa, H., Osmanova, N., Ayoub, N. , Mahran, L. (2009) “Spicatic acid: A 4-carboxygentisic acid from Gentiana spicata extract with potential hepatoprotective activity” Drug Disc Ther, 3(6):278-86 |
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